Broad-spectrum CC-chemokine blockade by gene transfer inhibits macrophage recruitment and atherosclerotic plaque formation in apolipoprotein E-knockout mice

Circulation

Volumn 110, Issue 16, 2004, Pages 2460-2466

  Bursill, Christina A ^a,b   Choudhury, Robin P ^a   Ali, Ziad ^a   Greaves, David R ^b   Channon, Keith M ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Aorta; Atherosclerosis; Gene therapy; Inflammation; Plaque

Indexed keywords

APOLIPOPROTEIN E; BETA CHEMOKINE; BETA CHEMOKINE INHIBITOR; GENE PRODUCT; GREEN FLUORESCENT PROTEIN; PROTEIN 35K; UNCLASSIFIED DRUG;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA ROOT; ARTICLE; ATHEROSCLEROTIC PLAQUE; CHEMOTAXIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DESCENDING AORTA; GENE TRANSFER; IN VITRO STUDY; INFLAMMATION; INHIBITION KINETICS; KNOCKOUT MOUSE; LIPID STORAGE; LIPOPROTEIN METABOLISM; MACROPHAGE; MACROPHAGE MIGRATION INHIBITION; MONOCYTE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; STATISTICAL SIGNIFICANCE; TISSUE HOMOGENATE; VACCINIA VIRUS; VIRUS RECOMBINANT;

ADENOVIRIDAE; ANIMALS; AORTIC DISEASES; APOLIPOPROTEINS E; ARTERIOSCLEROSIS; CELL MOVEMENT; CHEMOKINES, CC; CHEMOTAXIS; DIET, ATHEROGENIC; GENE THERAPY; GENETIC VECTORS; HYPERLIPOPROTEINEMIA TYPE II; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECOMBINANT FUSION PROTEINS; TRANSDUCTION, GENETIC; VACCINIA VIRUS; VIRAL PROTEINS;

EID: 6444228047     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000145122.58420.CO     Document Type: Article

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