Preconditioning by isoflurane is mediated by reactive oxygen species generated from mitochondrial electron transport chain complex III

Anesthesia and Analgesia

Volumn 99, Issue 5, 2004, Pages 1308-1315

  Ludwig, Lynda M ^b   Tanaka, Katsuya ^b   Eells, Janis T ^b   Weihrauch, Dorothee ^b   Pagel, Paul S ^b   Kersten, Judy R ^b   Warltier, David C ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; DIPHENYLIODONIUM SALT; DNA; INHALATION ANESTHETIC AGENT; ISOFLURANE; MYXOTHIAZOL; REACTIVE OXYGEN METABOLITE;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ELECTRON TRANSPORT; HEART INFARCTION; HEART INFARCTION PREVENTION; HEART INFARCTION SIZE; HEART MITOCHONDRION; INHALATION ANESTHESIA; NONHUMAN; PRIORITY JOURNAL; RABBIT;

ADENOSINE TRIPHOSPHATE; ANESTHETICS, INHALATION; ANIMALS; ELECTRON TRANSPORT; ENZYME INHIBITORS; HEMODYNAMIC PROCESSES; ISCHEMIC PRECONDITIONING, MYOCARDIAL; ISOFLURANE; MALE; METHACRYLATES; MITOCHONDRIA, HEART; MYOCARDIAL INFARCTION; NADH DEHYDROGENASE; ONIUM COMPOUNDS; RABBITS; REACTIVE OXYGEN SPECIES; THIAZOLES; UBIQUINONE; VENTRICULAR FUNCTION, LEFT;

EID: 6444220801     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/01.ANE.0000134804.09484.5D     Document Type: Article

References (25)

1. Mullenheim J, Ebel D, Frassdorf J, et al. Isoflurane preconditions myocardium against infarction via release of free radicals. Anesthesiology 2002;96:934-40.
2. Tanaka K, Weihrauch D, Kehl F, et al. Mechanism of preconditioning by isoflurane in rabbits: a direct role for reactive oxygen species. Anesthesiology 2002;97:1485-90.
3. Tritto I, D'Andrea D, Eramo N, et al. Oxygen radicals can induce preconditioning in rabbit hearts. Circ Res 1997;80:743-8.
4. Tanaka K, Weihrauch D, Ludwig LM, et al. Mitochondrial adenosine triphosphate-regulated potassium channel opening acts as a trigger for isoflurane-induced preconditioning by generating reactive oxygen species. Anesthesiology 2003;98:935-43.
5. Holmuhamedov EL, Jovanovic S, Dzeja PP, et al. Mitochondrial ATP-sensitive K+ channels modulate cardiac mitochondrial function. Am J Physiol Heart Circ Physiol 1998;275:H1567-76.
6. Turrens JF, Boveris A. Generation of Superoxide anion by the NADH dehydrogenase of bovine heart mitochondria. Biochem J 1980;191:421-7.
7. World Medical Association, American Physiological Society. Guiding principles for research involving animals and human beings. Am J Physiol Regul Integr Comp Physiol 2002;283: R281-3.
8. Institute of Laboratory Animal Resources, Commission on Life Sciences, National Research Council. Guide for the care and use of laboratory animals, 7th ed. Washington, D.C.: National Academy Press, 1996.
9. Ambrosio G, Zweier JL, Duilio C, et al. Evidence that mitochondrial respiration is a source of potentially toxic oxygen free radicals in intact rabbit hearts subjected to ischemia and reflow. J Biol Chem 1993;268:18532-41.
10. Vanden Hoek TL, Becker LB, Shao Z, et al. Reactive oxygen species released from mitochondria during brief hypoxia induce preconditioning in cardiomyocytes. J Biol Chem 1998;273:18092-8.
11. Carroll R, Gant VA, Yellon DM. Mitochondrial K(ATP) channel opening protects a human atrial-derived cell line by a mechanism involving free radical generation. Cardiovasc Res 2001;51:691-700.
12. Pain T, Yang XM, Critz SD, et al. Opening of mitochondrial K(ATP) channels triggers the preconditioned state by generating free radicals. Circ Res 2000;87:460-6.
13. McPherson BC, Yao Z. Signal transduction of opioid-induced cardioprotection in ischemia-reperfusion. Anesthesiology 2001;94:1082-8.
14. Yao Z, Tong J, Tan X, et al. Role of reactive oxygen species in acetylcholine-induced preconditioning in cardiomyocytes. Am J Physiol Heart Circ Physiol 1999;277:H2504-9.
15. Turrens JF. Superoxide production by the mitochondrial respiratory chain. Biosci Rep 1997;17:3-8.
16. Raha S, McEachern GE, Myint AT, Robinson BH. Superoxides from mitochondrial complex III: the role of manganese superoxide dismutase. Free Radic Biol Med 2000;29:170-80.
17. Li Y, Trush MA. Diphenyleneiodonium, an NAD(P)H oxidase inhibitor, also potently inhibits mitochondrial reactive oxygen species production. Biochem Biophys Res Commun 1998;253:295-9.
18. Majander A, Finel M, Wikstrom M. Diphenyleneiodonium inhibits reduction of iron-sulfur clusters in the mitochondrial NADH-ubiquinone oxidoreductase (Complex I). J Biol Chem 1994;269:21037-42.
19. Hanley PJ, Ray J, Brandt U, Daut J. Halothane, isoflurane and sevoflurane inhibit NADH:ubiquinone oxidoreductase (complex I) of cardiac mitochondria. J Physiol 2002;544:687-93.
20. Nishida M, Maruyama Y, Tanaka R, et al. G alpha(i) and G alpha(o) are target proteins of reactive oxygen species. Nature 2000;408:492-5.
21. Kulisz A, Chen N, Chandel NS, et al. Mitochondrial ROS initiate phosphorylation of p38 MAP kinase during hypoxia in cardiomyocytes. Am J Physiol Lung Cell Mol Physiol 2002;282:L1324-9.
22. Zhang DX, Chen YF, Campbell WB, et al. Characteristics and superoxide-induced activation of reconstituted myocardial mitochondrial ATP-sensitive potassium channels. Circ Res 2001;89:1177-83.
23. Dzeja PP, Holmuhamedov EL, Ozcan C, et al. Mitochondria: gateway for cytoprotection. Circ Res 2001;89:744-6.
24. Riess ML, Camara AK, Novalija E, et al. Anesthetic preconditioning attenuates mitochondrial Ca2+ overload during ischemia in Guinea pig intact hearts: reversal by 5-hydroxydecanoic acid. Anesth Analg 2002;95:1540-6.
25. Benov L, Sztejnberg L, Fridovich I. Critical evaluation of the use of hydroethidine as a measure of superoxide anion radical. Free Radic Biol Med 1998;25:826-31.