Halothane, isoflurane and sevolfurane inhibit NADH: Ubiquinone oxidoreductase (complex I) of cardiac mitochondria

Journal of Physiology

Volumn 544, Issue 3, 2002, Pages 687-693

  Hanley, Peter J ^a,b   Ray, John ^a   Brandt, Ulrich ^b   Daut, Jürgen ^a,b  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

HALOTHANE; INHALATION ANESTHETIC AGENT; ISOFLURANE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); ROTENONE; SEVOFLURANE; SUCCINATE DEHYDROGENASE; SUCCINIC ACID; UBIQUINONE DERIVATIVE; ETHER DERIVATIVE; NICOTINAMIDE ADENINE DINUCLEOTIDE; OXIDOREDUCTASE; DECYLUBIQUINONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; AUTOFLUORESCENCE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BINDING; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBSTRATE; GUINEA PIG; HEART MITOCHONDRION; HEART MUSCLE CELL; HEART PERFORMANCE; HEART VENTRICLE; HYPOTHESIS; MAMMAL; MINIMUM LUNG ALVEOLUS CONCENTRATION; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RESPIRATORY CHAIN; ANIMAL; DRUG ANTAGONISM; ENZYMOLOGY; FLUORESCENCE; METABOLISM; MUSCLE MITOCHONDRION; OXIDATION REDUCTION REACTION; PHYSIOLOGY; SUBMITOCHONDRIAL PARTICLE; DOSE RESPONSE; DRUG PROTEIN BINDING; ELECTRON TRANSPORT; HYDROPHOBICITY; ISCHEMIC PRECONDITIONING; PARTICLE SIZE; PIG;

ANESTHETICS, INHALATION; ANIMALS; ELECTRON TRANSPORT COMPLEX I; FLUORESCENCE; GUINEA PIGS; HALOTHANE; ISOFLURANE; METHYL ETHERS; MITOCHONDRIA, MUSCLE; MYOCYTES, CARDIAC; NAD; NADH, NADPH OXIDOREDUCTASES; OXIDATION-REDUCTION; SUBMITOCHONDRIAL PARTICLES; SUCCINIC ACID;

EID: 0036848476     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.2002.025015     Document Type: Article

References (40)

1. CHERVIN, C. & THIBAUD, M. C. (1992). Inhibition of plant and animal cytochrome oxidases by nitrous oxide as a function of cytochrome c concentration. Biochimie - Paris 74, 1125-1127.
2. CLARK, J. M. & SWITZER, R. L. (1977). Experimental Biochemistry, 2nd edn, pp.265-273. W. H. Freeman and Company, San Francisco.
3. 2+ release in rat ventricular myocytes. Anesthesiology 93, 1034-1044.
4. DEGLI ESPOSTI, M. (1998). Inhibitors of NADH-ubiquinone reductase: an overview. Biochimica et Biophysica Acta 1364, 222-235.
5. EINARSDÓTTIR, O. & CAUGHEY, W. S. (1988). Interactions of the anesthetic nitrous oxide with bovine heart cytochrome c oxidase. Journal of Biological Chemistry 263, 9199-9205.
6. EPSTEIN, R. H., STEIN, A. L., MARR, A. T. & LESSIN, J. B. (1998). High concentration versus incremental induction of anesthesia with sevoflurane in children: a comparison of induction times, vital signs, and complications. Journal of Clinical Anesthesiology 10, 41-45.
7. FRANKS, N. P. & LIEB, W. R. (1996). Temperature dependence of the potency of volatile general anesthetics: implications for in vitro experiments. Anesthesiology 84, 716-720.
8. GIBBS, C. L. (1982). Modification of the physiological determinants of cardiac energy expenditure by pharmacological agents. Pharmacology and Therapeutics 18, 133-157.
9. GRAHAM, T. P. JR, COVELL, J. W., SONNENBLICK, E. H., ROSS, J. JR & BRAUNWALD, E. (1968). Control of myocardial oxygen consumption: relative influence of contractile state and tension development. Journal of Clinical Investigation 47, 375-385.
10. HALL, G. M., KIRTLAND, S. J. & BAUM, H. (1973). The inhibition of mitochondrial respiration by inhalational anaesthetic agents. British Journal of Anaesthesia 45, 1005-1009.
11. HANLEY, P. J. & LOISELLE, D. S. (1998). Mechanisms of force inhibition by halothane and isoflurane in intact rat cardiac muscle. Journal of Physiology 506, 231-244.
12. ATP channel-independent targets of diazoxide and 5-hydroxy-decanoate in the heart. Journal of Physiology 542, 735-741.
13. HANNON, J. D., CODY, M. J. & HOUSMANS, P. R. (2001). Effects of isoflurane on intracellular calcium and myocardial crossbridge kinetics in tetanized papillary muscles. Anesthesiology 94, 856-861.
14. HARRISON, S. M., ROBINSON, M., DAVIES, L. A., HOPKINS, P. M. & BOYETT, M. R. (1999). Mechanisms underlying the inotropic action of halothane on intact rat ventricular myocytes. British Journal of Anaesthesia 82, 609-621.
15. +) induces NADH-dependent superoxide formation and enhances NADH-dependent lipid perioxidation in bovine heart submitochondrial particles. Biochemical and Biophysical Research Communications 170, 1049-1055.
16. 2+ transient in ferret cardiac muscle. Anesthesiology 93, 189-201.
17. IDE, T., TSUTSUI, H., KINUGAWA, S., UTSUMI, H., KANG, D., HATTORI, N., UCHIDA, K., ARIMURA, K., EGASHIRA, K. & TAKESHITA, A. (1999). Mitochondrial electron transport complex I is a potential source of oxygen free radicals in the failing myocardium. Circulation Research 85, 357-363.
18. i in intact rat trabeculae. American Journal of Physiology 273, C2046-2056.
19. 2+ content, and force in intact rat heart trabeculae. American Journal of Physiology 274, H106-114.
20. 2+ content, and twitch force in intact trabeculae. American Journal of Physiology 275, H1360-1369.
21. KISSIN, I., AULTMAN, D. F. & SMITH, L. R. (1983). Effects of volatile anesthetics on myocardial oxidation-reduction status assessed by NADH fluorometry. Anesthesiology 59, 447-452.
22. KWEK, T. K. & NG, A. (1997). Laryngeal mask insertion following inhalational induction in children: a comparison between halothane and sevoflurane. Anaesthesia and Intensive Care 25, 413-416.
23. LENAZ, G. (1998). Quinone specificity of complex I. Biochimica et Biophysica Acta 1364, 207-221.
24. MCAULIFFE, J. J. & HICKEY, P. R. (1987). The effect of halothane on the steady-state levels of high-energy phosphates in the neonatal heart. Anesthesiology 67, 231-235.
25. MCKENZIE, D., FRANKS, N. P. & LIEB, W. R. (1995). Actions of general anaesthetics on a neuronal nicotinic acetylcholine receptor in isolated identified neurones of Lymnaea stagnalis. British Journal of Pharmacology 115, 275-282.
26. MERIN, R. G. (1973). Inhalation anesthetics and myocardial metabolism: possible mechanisms of functional effects. Anesthesiology 39, 216-255.
27. MONTGOMERY, H. (2000). Cardiac reserve: linking physiology and genetics. Intensive Care Medicine 26, S137-144.
28. MÜLLENHEIM, J., EBEL, D., FRÄßDORF, J., PRECKEL, B., THÄMER, V. & SCHLACK, W. (2002). Isoflurane preconditions myocardium against infarction via release of free radicals. Anesthesiology 96, 934-940.
29. 31P NMR spectroscopy. Anesthesiology 67, 649-653.
30. NOVALIJA, E., VARADARAJAN, S. G., CAMARA, A. K. S., AN, J., CHEN, Q., RIESS, M., HOGG, N. & STOWE, D. F. (2002). Anesthetic preconditioning: Triggering role of reactive oxygen and nitrogen species in isolated hearts. American Journal of Physiology - Heart and Circulatory Physiology 283, H44-52.
31. OKUN, J. G., LÜMMEN, P. & BRANDT, U. (1999). Three classes of inhibitors share a common binding domain in mitochondrial complex I (NADH:ubiquinone oxidoreductase). Journal of Biochemistry 274, 2625-2630.
32. RAY, J., NOLL, F., DAUT, J. & HANLEY, P. J. (2002). Long-chain fatty acids increase basal metabolism and depolarize mitochondria in cardiac muscle cells. American Journal of Physiology - Heart and Circulatory Physiology 282, H1495-1501.
33. RIESS, M. L., CAMARA, A. K. S., CHEN, Q., NOVALIJA, E., RHODES, S. S. & STOWE, D. F. (2002). Altered NADH and improved function by anesthetic and ischemic preconditioning in guinea-pig intact hearts. American Journal of Physiology - Heart and Circulatory Physiology 283, H53-60.
34. RUSY, B. F. & KOMAI, H. (1987). Anesthetic depression of myocardial contractility: a review of possible mechanisms. Anesthesiology 67, 745-766.
35. +-ATPase in guinea-pig cardiac ventricular muscle. Journal of Physiology 481, 647-662.
36. SMITH, A. L. (1967). Preparation, properties, and conditions for assay of mitochondria: slaughterhouse material, small-scale. Methods in Enzymology 10, 81-86.
37. SOWA, S., DONG, A., ROOS, E. E. & CAUGHEY, W. S. (1987). The anesthetic nitrous oxide affects dioxygen utilization by bovine heart and bean seed mitochondrial particles. Biochemical and Biophysical Research Communications 144, 643-648.
38. TANAKA, K., WEIHRAUCH, D., KERSTEN, J. R., PAGEL, P. S. & WARLTIER, D. C. (2002). Mechanism of isoflurane-induced preconditioning in rabbits: a role for reactive oxygen species. Anesthesiology A-627, in the Press.
39. 1 segment of the respiratory chain. Biochimica et Biophysica Acta 638, 282-289.
40. TURRENS, J. F. & BOVERIS, A. (1980). Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria. Biochemical Journal 191, 421-427.