Markedly diminished drug resistance-inducing properties of vinflunine (20′,20′-difluoro-3′,4′-dihydrovinorelbine) relative to vinorelbine, identified in murine and human tumour cells in vivo and in vitro

Cancer Chemotherapy and Pharmacology

Volumn 48, Issue 1, 2001, Pages 62-70

  Etievant C ^a   Kruczynski, A ^a   Barret, J M ^a   Tait, A S ^a   Kavallaris, M ^a   Hill, B T ^a  

^a INSTITUT DE RECHERCHE PIERRE FABRE   (France)

Author keywords

In vivo in vitro resistance selection; Multidrug resistance; Vinca alkaloid; Vinflunine; Tubulin isotypes

Indexed keywords

BETA TUBULIN; CAMPTOTHECIN; CISPLATIN; DOXORUBICIN; NAVELBINE; VERAPAMIL; VINCA ALKALOID; VINFLUNINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CARCINOMA CELL; CONTROLLED STUDY; DRUG SENSITIVITY; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LEUKEMIA CELL; LUNG CARCINOMA; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR CELL;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; FEMALE; LEUKEMIA P388; MICE; MICE, INBRED DBA; TUBULIN; TUMOR CELLS, CULTURED; VINBLASTINE;

EID: 0034918410     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002800100275     Document Type: Article

References (24)

1. P-glycoprotein mediated resistance to 5′-nor-anhydro-vinblastine (Navelbine®)
2. Characterisation of the in vivo and in vitro cellular resistance phenotype to vinflunine, a novel fluorinated Vinca alkaloid
3. The role of β-tubulin isotypes in resistance to antimitotic drugs
4. A mechanism of cellular resistance to drugs that interfere with microtubule assembly
5. Mechanisms of action of and resistance to antitubulin agents: Microtubule dynamics, drug transport, and cell death
6. Vinflunine (20′,20′-difluoro-3′,4′-dihydrovinorelbine), a novel Vinca alkaloid, which participates in P-glycoprotein (Pgp)-mediated multidrug resistance in vivo and in vitro
7. Vinca alkaloids in superacidic media: A method for creating a new family of antitumor derivatives
8. Altered expression of Mβ2, the class II β-tubulin isotype, in murine J744.2 cell line with a high level of Taxol resistance
9. Differing patterns of cross resistance resulting from exposures to specific antitumour drugs or to radiation in vitro
10. Superior in vivo experimental antitumour activity of vinflunine, relative to vinorelbine, in a panel of human tumour xenografts
11. Novel mechanism of resistance to paclitaxel (Taxol) in human K562 leukemia cells by combined selection with PSC 833
12. Taxol-resistant epithelial ovarian tumors are associated with altered expression of specific β-tubulin isotypes
13. Antisense oligonucleotides to class III beta-tubulin sensitize drug-resistant cells to Taxol
14. Decreased expression of class III β-tubulin associated with Vinca alkaloid resistance in pediatric cancer
15. Antimitotic and tubulin-interacting properties of vinflunine, a novel fluorinated Vinca alkaloid
16. Preclinical in vitro antitumor activity of vinflunine, a novel fluorinated Vinca alkaloid
17. Effects of Taxol on the polymerization and posttranscriptional modification of class III β-tubulin in P19 embryonal carcinoma cells
18. A comparison of thermodynamic parameters for vinorelbine- and vinflunine-induced tubulin self-association by sedimentation velocity
19. Multiple forms of tubulin: Different gene products and covalent modifications
20. Novel actions of antitumor drugs vinflunine and vinorelbine on microtubules
21. Quantitative analysis of MDR1 (multidrug resistant) gene expression in human tumors by polymerase chain reaction
22. Altered beta-tubulin isotype expression in paclitaxel-resistant human prostate carcinoma cells
23. Preclinical drug development; rationale and methods
24. UKCCCR guidelines for the welfare of animals in experimental neoplasia