Novel exon of mammalian ADAR2 extends open reading frame

PLoS ONE

Volumn 4, Issue 1, 2009, Pages

  Maas, Stefan ^a   Gommans, Willemijn M ^a  

^a LEHIGH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DEAMINASE; ADENOSINE DEAMINASE THAT ACT ON RNA1; ADENOSINE DEAMINASE THAT ACT ON RNA2; ADENOSINE DEAMINASE THAT ACT ON RNA3; MEMBRANE PROTEIN; UNCLASSIFIED DRUG; DSRNA ADENOSINE DEAMINASE;

AMINO ACID SEQUENCE; ANIMAL TISSUE; ARTICLE; CEREBELLUM; CONTROLLED STUDY; EXON; GENETIC VARIABILITY; HUMAN; HUMAN CELL; HUMAN TISSUE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN MOTIF; RNA BINDING; RNA SPLICING; TISSUE DISTRIBUTION; ALTERNATIVE RNA SPLICING; ANIMAL; BIOLOGICAL MODEL; GENETICS; MOLECULAR GENETICS; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; RAT; RNA EDITING; RNA PROCESSING;

MAMMALIA; MUS; RATTUS;

ADENOSINE DEAMINASE; ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; EXONS; HUMANS; MICE; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; OPEN READING FRAMES; PROTEIN STRUCTURE, TERTIARY; RATS; RNA EDITING; RNA PROCESSING, POST-TRANSCRIPTIONAL;

EID: 64349087874     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0004225     Document Type: Article

References (30)

1. Bass BL (2002) RNA editing by adenosine deaminases that act on RNA. Annu Rev Biochem 71: 817-846.
2. Maydanovych O, Beal PA (2006) Breaking the central dogma by RNA editing. Chem Rev 106: 3397-3411.
3. Gommans WM, Dupuis DE, McCane JE, Tatalias NE, Maas S (2008) Diversifying Exon Code through A-to-I RNA Editing. In: Smith H, ed. DNA RNA Editing Wiley & Sons, Inc. pp 3-30.
4. Higuchi M, Maas S, Single FN, Hartner J, Rozov A, et al. (2000) Point mutation in an AMPA receptor gene rescues lethality in mice deficient in the RNA-editing enzyme ADAR2. Nature 406: 78-81.
5. Athanasiadis A, Rich A, Maas S (2004) Widespread A-to-I RNA editing of Alu-containing mRNAs in the human transcriptome. PLoS Biol 2: e391.
6. Blow M, Futreal PA, Wooster R, Stratton MR (2004) A survey of RNA editing in human brain. Genome Res 14: 2379-2387.
7. Levanon EY, Eisenberg E, Yelin R, Nemzer S, Hallegger M, et al. (2004) Systematic identification of abundant A-to-I editing sites in the human transcriptome. Nat Biotechnol 22: 1001-1005.
8. Blow MJ, Grocock RJ, van Dongen S, Enright AJ, Dicks E, et al. (2006) RNA editing of human microRNAs. Genome Biol 7: R27.
9. Luciano DJ, Mirsky H, Vendetti NJ, Maas S (2004) RNA editing of a miRNA precursor. Rna 10: 1174-1177.
10. Yang W, Chendrimada TP, Wang Q, Higuchi M, Seeburg PH, et al. (2006) Modulation of microRNA processing and expression through RNA editing by ADAR deaminases. Nat Struct Mol Biol 13: 13-21.
11. Maas S, Kawahara Y, Tamburro KM, Nishikura K (2006) A-to-I RNA editing and human disease. RNA Biol 3: 1-9.
12. Melcher T, Maas S, Herb A, Sprengel R, Higuchi M, et al. (1996) RED2, a brain-specific member of the RNA-specific adenosine deaminase family. J Biol Chem 271: 31795-31798.
13. Gerber A, O'Connell MA, Keller W (1997) Two forms of human double-stranded RNA-specific editase 1 (hRED1) generated by the insertion of an Alu cassette. Rna 3: 453-463.
14. Rueter SM, Dawson TR, Emeson RB (1999) Regulation of alternative splicing by RNA editing. Nature 399: 75-80.
15. Lai F, Chen CX, Carter KC, Nishikura K (1997) Editing of glutamate receptor B subunit ion channel RNAs by four alternatively spliced DRADA2 double-stranded RNA adenosine deaminases. Mol Cell Biol 17: 2413-2424.
16. Mittaz L, Scott HS, Rossier C, Seeburg PH, Higuchi M, et al. (1997) Cloning of a human RNA editing deaminase (ADARB1) of glutamate receptors that maps to chromosome 21q22.3. Genomics 41: 210-217.
17. Slavov D, Gardiner K (2002) Phylogenetic comparison of the pre-mRNA adenosine deaminase ADAR2 genes and transcripts: conservation and diversity in editing site sequence and alternative splicing patterns. Gene 299: 83-94.
18. George CX, Samuel CE (1999) Human RNA-specific adenosine deaminase ADAR1 transcripts possess alternative exon 1 structures that initiate from different promoters, one constitutively active and the other interferon inducible. Proc Natl Acad Sci U S A 96: 4621-4626.
19. George CX, Wagner MV, Samuel CE (2005) Expression of interferon-inducible RNA adenosine deaminase ADAR1 during pathogen infection and mouse embryo development involves tissue-selective promoter utilization and alternative splicing. J Biol Chem 280: 15020-15028.
20. Villard L, Tassone F, Haymowicz M, Welborn R, Gardiner K (1997) Map location, genomic organization and expression patterns of the human RED1 RNA editase. Somat Cell Mol Genet 23: 135-145.
21. Chen CX, Cho DS, Wang Q, Lai F, Carter KC, et al. (2000) A third member of the RNA-specific adenosine deaminase gene family, ADAR3, contains both single- and double-stranded RNA binding domains. Rna 6: 755-767.
22. Kuhn RM, Karolchik D, Zweig AS, Trumbower H, Thomas DJ, et al. (2007) The UCSC genome browser database: update 2007. Nucleic Acids Res 35: D668-673.
23. A S, Haussler D (2004) Computational identification of evolutionarily conserved exons. Proceedings of the eighth annual international conference on Research in computational molecular biology RECOMB'04. pp 177-186.
24. Siepel A, Bejerano G, Pedersen JS, Hinrichs AS, Hou M, et al. (2005) Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes. Genome Res 15: 1034-1050.
25. Prestridge DS (1995) Predicting Pol II promoter sequences using transcription factor binding sites. J Mol Biol 249: 923-932.
26. Maas S, Patt S, Schrey M, Rich A (2001) Underediting of glutamate receptor GluR-B mRNA in malignant gliomas. Proc Natl Acad Sci U S A 98: 14687-14692.
27. Lomeli H, Mosbacher J, Melcher T, Hoger T, Geiger JR, et al. (1994) Control of kinetic properties of AMPA receptor channels by nuclear RNA editing. Science 266: 1709-1713.
28. Yang W, Wang Q, Kanes SJ, Murray JM, Nishikura K (2004) Altered RNA editing of serotonin 5-HT(2C) receptor induced by interferon: implications for depression associated with cytokine therapy. Brain Res Mol Brain Res 124: 70-78.
29. Feng Y, Sansam CL, Singh M, Emeson RB (2006) Altered RNA editing in mice lacking ADAR2 autoregulation. Mol Cell Biol 26: 480-488.
30. Singh M, Kesterson RA, Jacobs MM, Joers JM, Gore JC, et al. (2007) Hyperphagia-mediated obesity in transgenic mice misexpressing the RNA-editing enzyme ADAR2. J Biol Chem 282: 22448-22459.