Single and combined effects of cerebral white matter lesions and lacunar infarctions on cognitive function in an elderly population

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 64, Issue 1, 2009, Pages 118-124

  Baune, Bernard T ^a,b   Roesler, Andreas ^c   Knecht, Stefan ^b   Berger, Klaus ^b  

^a JAMES COOK UNIVERSITY   (Australia)

^b UNIVERSITY OF MÜNSTER   (Germany)

^c KLINIKUM AUGSBURG   (Germany)

Author keywords

Brain infarcts; Cognitive function; Elderly; White matter lesions

Indexed keywords

AGE DISTRIBUTION; AGED; ARTICLE; BRAIN BLOOD VESSEL; BRAIN DAMAGE; BRAIN INFARCTION; CEREBRAL WHITE MATTER LESION; COGNITION; COMORBIDITY; CONTROLLED STUDY; DISEASE ASSOCIATION; EDUCATION; FEMALE; GERIATRIC PATIENT; GERMANY; HUMAN; LACUNAR INFARCTION; MAJOR CLINICAL STUDY; MALE; MEMORY; MOTOR PERFORMANCE; NEUROPSYCHOLOGICAL TEST; NEUROTRANSMISSION; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; SEX DIFFERENCE; COGNITIVE DEFECT; COMPARATIVE STUDY; FOLLOW UP; LEUKOARAIOSIS; PHYSIOLOGY; PROGNOSIS; PSYCHOLOGIC TEST; PSYCHOLOGICAL ASPECT; RETROSPECTIVE STUDY; RISK FACTOR;

AGED; AGED, 80 AND OVER; CEREBRAL INFARCTION; COGNITION; COGNITION DISORDERS; FEMALE; FOLLOW-UP STUDIES; HUMANS; LEUKOARAIOSIS; MAGNETIC RESONANCE IMAGING; MALE; PROGNOSIS; PSYCHOLOGICAL TESTS; RETROSPECTIVE STUDIES; RISK FACTORS;

EID: 64249159777     PISSN: 10795006     EISSN: None     Source Type: Journal    
DOI: 10.1093/gerona/gln004     Document Type: Article

References (49)

1. Scheltens P, Barkhof F, Valk J, et al. White matter lesions on magnetic resonance imaging in clinically diagnosed Alzheimer's disease. Evidence for heterogeneity. Brain. 1992;115(pt 3):735-748.
2. de Leeuw FE, de Groot JC, Achten E, et al. Prevalence of cerebral white matter lesions in elderly people: a population based magnetic resonance imaging study. The Rotterdam Scan Study. J Neurol Neurosurg Psychiatry. 2001;70:9-14. (Pubitemid 32096113)
3. Schmidt R, Scheltens P, Erkinjuntti T, et al. White matter lesion progression: a surrogate endpoint for trials in cerebral small-vessel disease. Neurology. 2004;63:139-144. (Pubitemid 38943791)
4. Gunning-Dixon FM, Raz N. The cognitive correlates of white matter abnormalities in normal aging: a quantitative review. Neuropsychology. 2000;14:224-232. (Pubitemid 30687601)
5. de Groot JC, de Leeuw FE, Oudkerk M, et al. Cerebral white matter lesions and cognitive function: the Rotterdam Scan Study. Ann Neurol. 2000;47:145-151. (Pubitemid 30078560)
6. Deary IJ, Leaper SA, Murray AD, et al. Cerebral white matter abnormalities and lifetime cognitive change: a 67-year follow-up of the Scottish Mental Survey of 1932. Psychol Aging. 2003;18:140-148.
7. Almkvist O, Wahlund LO, Andersson-Lundman G, et al. White-matter hyperintensity and neuropsychological functions in dementia and healthy aging. Arch Neurol. 1992;49:626-632.
8. Boone KB, Miller BL, Lesser IM, et al. Neuropsychological correlates of white-matter lesions in healthy elderly subjects. A threshold effect. Arch Neurol. 1992;49:549-554.
9. Ylikoski R, Ylikoski A, Erkinjuntti T, et al. White matter changes in healthy elderly persons correlate with attention and speed of mental processing. Arch Neurol. 1993;50:818-824. (Pubitemid 23229307)
10. Junque C, Pujol J, Vendrell P, et al. Leuko-araiosis on magnetic resonance imaging and speed of mental processing. Arch Neurol. 1990;47:151-156. (Pubitemid 20058110)
11. Baum KA, Schulte C, Girke W, et al. Incidental white-matter foci on MRI in " healthy " subjects: evidence of subtle cognitive dysfunction. Neuroradiology. 1996;38:755-760
12. van Swieten JC, Staal S, Kappelle LJ, et al. Are white matter lesions directly associated with cognitive impairment in patients with lacunar infarcts? J Neurol. 1996;243:196-200. (Pubitemid 26026658)
13. Erkinjuntti T. Subcortical vascular dementia. Cerebrovasc Dis. 2002;13(suppl 2):58-60.
14. Wen HM, Mok VC, Fan YH, et al. Effect of white matter changes on cognitive impairment in patients with lacunar infarcts. Stroke. 2004;35:1826-1830. (Pubitemid 38971859)
15. Jokinen H, Kalska H, Mantyla R, et al. Cognitive profile of subcortical ischaemic vascular disease. J Neurol Neurosurg Psychiatry. 2006;77:28-33. (Pubitemid 43022686)
16. Burns JM, Church JA, Johnson DK, et al. White matter lesions are prevalent but differentially related with cognition in aging and early Alzheimer disease. Arch Neurol. 2005;62:1870-1876.
17. Reed BR, Eberling JL, Mungas D, et al. Effects of white matter lesions and lacunes on cortical function. Arch Neurol. 2004;61:1545-1550. (Pubitemid 39350265)
18. de Groot JC, de Leeuw FE, Oudkerk M, et al. Cerebral white matter lesions and subjective cognitive dysfunction: the Rotterdam Scan Study. Neurology. 2001;56:1539-1545. (Pubitemid 32532267)
19. van Zandvoort MJ, van der Grond J, Kappelle LJ, et al. Cognitive deficits and changes in neurometabolites after a lacunar infarct. J Neurol. 2005;252:183-190.
20. Appelros P, Samuelsson M, Lindell D. Lacunar infarcts: functional and cognitive outcomes at five years in relation to MRI findings. Cerebrovasc Dis. 2005;20:34-40. (Pubitemid 41003633)
21. van der Flier WM, van Straaten EC, Barkhof F, et al. Small vessel disease and general cognitive function in nondisabled elderly: the LADIS study. Stroke. 2005;36:2116-2120. (Pubitemid 41429230)
22. Sierra C, Coca A. White matter lesions and cognitive impairment as silent cerebral disease in hypertension. Scientific World Journal. 2006;6:494-501.
23. Schmidt WP, Roesler A, Kretzschmar K, et al. Functional and cognitive consequences of silent stroke discovered using brain magnetic resonance imaging in an elderly population. J Am Geriatr Soc. 2004;52:1045-1050. (Pubitemid 38869061)
24. Keil U, Filipiak B, Doring A, et al. Monitoring trends and determinants in cardiovascular disease in Germany: results of the MONICA Project Augsburg, 1985-1990. MMWR Morb Mortal Wkly Rep. 1992;41(suppl):171-179.
25. Radloff LS. The CES-D scale: a self-report depression scale for research in the general population. Appl Psychol Meas. 1977;1:385-401.
26. Nilsson L-G, Söderlund H, Berger K, et al. Cognitive test battery of CASCADE. Aging Neuropsychol Cogn. 2005;12:32-56.
27. Baune BT, Suslow T, Arolt V, et al. The relationship between psychological dimensions of depressive symptoms and cognitive functioning in the elderly - the MEMO-Study. J Psychiatr Res. 2007;41:247-254. (Pubitemid 44854993)
28. Baune BT, Suslow T, Engelien A, et al. The association between depressive mood and cognitive performance in an elderly general population - the MEMO Study. Dement Geriatr Cogn Disord. 2006;22:142-149. (Pubitemid 44253210)
29. Tulving E, Colotla VA. Free recall of trilingual words. Cognit Psychol. 1970;1:86-98.
30. Nilsson L-G, Bäckman L, Erngrund K, et al. The Betula Prospective Cohort Study: memory, health, and aging. Aging Neuropsychol Cogn. 1997;4:1-32. (Pubitemid 27245220)
31. Backman L, Nilsson L-G. Semantic memory functioning across the adult life span. Eur Psychol. 1996;1:27-33.
32. Nyberg L, Maitland SB, Ronnlund M, et al. Selective adult age differences in an age-invariant multifactor model of declarative memory. Psychol Aging. 2003;18:149-160. (Pubitemid 36293052)
33. Stroop AP. Studies of interference in serial verbal reactions. J Exp Psychol. 1935;18:643-662.
34. Salthouse T. The role of memory in the age decline in digit-symbol substitution performance. J Gerontol. 1978;33:232-238. (Pubitemid 8290877)
35. Wechsler D. 1981. Wechsler Adult Intelligence Scale-Revised. New York: Psychological Corporation.
36. Costa LD, Vaughn HGJ, Levita E, et al. Perdue Pegboard as a predictor of the presence and laterality of cerebral lesions. Journal of Consulting Psychology. 1963;27:133-137.
37. Desrosiers J, Hebert R, Bravo G, et al. The Purdue Pegboard Test: normative data for people aged 60 and older. Disabil Rehabil. 1995;17:217-224.
38. Tiffin J. 1948. SRA Examiner's Manual for the Perdue Pegboard. Volume II. Chicago: SRS.
39. Achten E, Breteler M, De Leeuw F. Rating scale for age related brain changes. Imaging Decis MRI. 2000;4:10-19. (Pubitemid 30214658)
40. Scheltens P, Erkinjunti T, Leys D, et al. White matter changes on CT and MRI: an overview of visual rating scales. European Task Force on Age-Related White Matter Changes. Eur Neurol. 1998;39:80-89.
41. Launer LJ, Oudkerk M, Nilsson LG, et al. CASCADE: a European collaborative study on vascular determinants of brain lesions. Study design and objectives. Neuroepidemiology. 2000;19:113-120. (Pubitemid 30146441)
42. Schmidt R, Ropele S, Enzinger C, et al. White matter lesion progression, brain atrophy, and cognitive decline: the Austrian stroke prevention study. Ann Neurol. 2005;58:610-616. (Pubitemid 41377225)
43. Jokinen H, Kalska H, Mantyla R, et al. White matter hyperintensities as a predictor of neuropsychological deficits post-stroke. J Neurol Neurosurg Psychiatry. 2005;76:1229-1233. (Pubitemid 41208373)
44. Rasquin SM, Verhey FR, Lousberg R, et al. Cognitive performance after first ever stroke related to progression of vascular brain damage: a 2 year follow up CT scan study. J Neurol Neurosurg Psychiatry. 2005;76:1075-1079. (Pubitemid 41081279)
45. Vermeer SE, Prins ND, den Heijer T, et al. Silent brain infarcts and the risk of dementia and cognitive decline. N Engl J Med. 2003;348:1215-1222.
46. Fazekas F, Kleinert R, Offenbacher H, et al. Pathologic correlates of incidental MRI white matter signal hyperintensities. Neurology. 1993;43:1683-1689. (Pubitemid 23307935)
47. Schmidt R, Enzinger C, Ropele S, et al. Progression of cerebral white matter lesions: 6-year results of the Austrian Stroke Prevention Study. Lancet. 2003;361:2046-2048. (Pubitemid 36695049)
48. De Groot JC, De Leeuw FE, Oudkerk M, et al. Periventricular cerebral white matter lesions predict rate of cognitive decline. Ann Neurol. 2002;52:335-341. (Pubitemid 35001500)
49. Appelros P, Andersson AG. Changes in Mini Mental State Examination score after stroke: lacunar infarction predicts cognitive decline. Eur J Neurol. 2006;13:491-495. (Pubitemid 43823364)