Recombinant Ov-ASP-1, a Th1-biased protein adjuvant derived from the helminth Onchocerca volvulus, can directly bind and activate antigen-presenting cells

Journal of Immunology

Volumn 182, Issue 7, 2009, Pages 4005-4016

  He, Yuxian ^a,b   Barker, Sophie J ^c,d   MacDonald, Angus J ^a,c,h   Yu, Yu ^a   Cao, Long ^a   Li, Jingjing ^a   Parhar, Ranjit ^a   Heck, Susanne ^a   Hartmann, Susanne ^e   Golenbock, Douglas T ^f   Jiang, Shibo ^a   Libri, Nathan A ^c   Semper, Amanda E ^c   Rosenberg, William M ^c,g   Lustigman, Sara ^a  

^a NEW YORK BLOOD CENTER   (United States)

^b INSTITUTE OF PATHOGEN BIOLOGY   (China)

^c SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

^d UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^e HUMBOLDT UNIVERSITY   (Germany)

^f UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^g UNIVERSITY COLLEGE LONDON   (United Kingdom)

^h PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADJUVANT; CYTOKINE; RECOMBINANT PROTEIN; T LYMPHOCYTE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; HELMINTH PROTEIN; IMMUNOLOGICAL ADJUVANT; MEMBRANE PROTEIN; OV ASP 1 PROTEIN, ONCHOCERCA VOLVULUS; OV-ASP-1 PROTEIN, ONCHOCERCA VOLVULUS; PARASITE ANTIGEN; SPIKE GLYCOPROTEIN, CORONAVIRUS; VIRUS ENVELOPE PROTEIN;

ANIMAL EXPERIMENT; ANTIGEN PRESENTING CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DRUG MECHANISM; FEMALE; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCHOCERCA VOLVULUS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION; TH1 CELL; ANIMAL; ANTIGEN PRESENTATION; BIOSYNTHESIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; TH2 CELL;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIGEN PRESENTATION; ANTIGEN-PRESENTING CELLS; ANTIGENS, HELMINTH; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HELMINTH PROTEINS; HUMANS; LYMPHOCYTE ACTIVATION; MEMBRANE GLYCOPROTEINS; MICE; RECOMBINANT PROTEINS; TH1 CELLS; TH2 CELLS; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; VIRAL ENVELOPE PROTEINS;

EID: 64249151886     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0800531     Document Type: Article

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