Identification of immunodominant sites on the spike protein of severe acute respiratory syndrome (SARS) coronavirus: Implication for developing SARS diagnostics and vaccines

Journal of Immunology

Volumn 173, Issue 6, 2004, Pages 4050-4057

  He, Yuxian ^a   Zhou, Yusen ^b   Wu, Hao ^c   Luo, Baojun ^b   Chen, Jingming ^d   Li, Wanbo ^d   Jiang, Shibo ^a  

^a NEW YORK BLOOD CENTER   (United States)

^b BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

^c CAPITAL MEDICAL UNIVERSITY   (China)

^d Gene Gateway   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; SYNTHETIC PEPTIDE; VIRUS SPIKE PROTEIN;

ADULT; AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY COMBINING SITE; ANTIBODY RESPONSE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CONVALESCENCE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOGENICITY; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RABBIT; SARS CORONAVIRUS; SEVERE ACUTE RESPIRATORY SYNDROME; VACCINE PRODUCTION;

EID: 4644338506     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.173.6.4050     Document Type: Article

References (34)

1. Drosten, C., S. Gunther, W. Preiser, W. S. van der, H. R. Brodt, S. Becker, H. Rabenau, M. Panning, L. Kolesnikova, R. A. Fouchier, et al. 2003. Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N. Engl. J. Med. 348:1967.
2. Ksiazek, T. G., D. Erdman, C. S. Goldsmith, S. R. Zaki, T. Peret, S. Emery, S. Tong, C. Urbani, J. A. Comer, W. Lim, et al. 2003. A novel coronavirus associated with severe acute respiratory syndrome. N. Engl. J. Med. 348:1953.
3. Peiris, J. S., S. T. Lai, L. L. Poon, Y. Guan, L. Y. Yam, W. Lim, J. Nicholls, W. K. Yee, W. W. Yan, M. T. Cheung, et al. 2003. Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet 361:1319.
4. Marra, M. A., S. J. Jones, C. R. Astell, R. A. Holt, A. Brooks-Wilson, Y. S. Butterfield, J. Khattra, J. K. Asano, S. A. Barber, S. Y. Chan, et al. 2003. The genome sequence of the SARS-associated coronavirus. Science 300:1399.
5. Qin, E., Q. Zhu, M. Yu, B. Fan, G. Chang, B. Si, B. Yang, W. Peng, T. Jiang, B. Liu, et al. 2003. A complete sequence and comparative analysis of a SARS-associated virus (isolate BJ01). Chin. Sci. Bull. 48:941.
6. Rota, P. A., M. S. Oberste, S. S. Monroe, W. A. Nix, R. Campagnoli, J. P. Icenogle, S. Penaranda, B. Bankamp, K. Maher, M. H. Chen, et al. 2003. Characterization of a novel coronavirus associated with severe acute respiratory syndrome. Science 300:1394.
7. Holmes, K. V., and L. Enjuanes. 2003. Virology: the SARS coronavirus: A postgenomic era. Science 300:1377.
8. Spiga, O., A. Bernini, A. Ciutti, S. Chiellini, N. Menciassi, F. Finetti, V. Causarono, F. Anselmi, F. Prischi, and N. Niccolai. 2003. Molecular modelling of S1 and S2 subunits of SARS coronavirus spike glycoprotein. Biochem. Biophys. Res. Commun. 310:78.
9. Li, W., M. J. Moore, N. Vasilieva, J. Sui, S. K. Wong, M. A. Berne, M. Somasundaran, J. L. Sullivan, K. Luzuriaga, T. C. Greenough, et al. 2003. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature 426:450.
10. Prabakaran, P., X. Xiao, and D. S. Dimitrov. 2004. A model of the ACE2 structure and function as a SARS-CoV receptor. Biochem. Biophys. Res. Commun. 314:235.
11. Babcock, G. J., D. J. Esshaki, W. D. Thomas, Jr., and D. M. Ambrosino. 2004. Amino acids 270 to 510 of the severe acute respiratory syndrome coronavirus spike protein are required for interaction with receptor. J. Virol. 78:4552.
12. Wong, S. K., W. Li, M. J. Moore, H. Choe, and M. Farzan. 2004. A 193-amino acid fragment of the SARS coronavirus S protein efficiently binds angiotensin-converting enzyme 2. J. Biol. Chem. 279:3197.
13. Xiao, X., S. Chakraborti, A. S. Dimitrov, K. Gramatikoff, and D. S. Dimitrov. 2003. The SARS-CoV S glycoprotein: expression and functional characterization. Biochem. Biophys. Res. Commun. 312:1159.
14. Dimitrov, D. S. 2003. The secret life of ACE2 as a receptor for the SARS virus. Cell 115:652.
15. Wang, P., J. Chen, A. Zheng, Y. Nie, X. Shi, W. Wang, G. Wang, M. Luo, H. Liu, L. Tan, et al. 2004. Expression cloning of functional receptor used by SARS coronavirus. Biochem. Biophys. Res. Commun. 315:439.
16. Liu, S., G. Xiao, Y. Chen, Y. He, J. Niu, C. R. Escalante, H. Xiong, J. Farmar, A. K. Debnath, P. Tien, and S. Jiang. 2004. Interaction between heptad repeat 1 and 2 regions in spike protein of SARS-associated coronavirus: implications for virus fusogenic mechanism and identification of fusion inhibitors. Lancet 363:938.
17. Tripet, B., M. W. Howard, M. Jobling, R. K. Holmes, K. V. Holmes, and R. S. Hodges. 2004. Structural characterization of the SARS-coronavirus spike S fusion protein core. J. Biol. Chem. 279:20836.
18. Gallagher, T. M., and M. J. Buchmejer. 2001. Coronavirus spike proteins in viral entry and pathogenesis. Virology 279:371.
19. Holmes, K. V. 2003. SARS coronavirus: a new challenge for prevention and therapy. J. Clin. Invest. 111:1605.
20. Holmes, K. V. 2003. SARS-associated coronavirus. N. Engl. J. Med. 348:1948.
21. Nakanaga, K., K. Yamanouchi, and K. Fujiwara. 1986. Protective effect of monoclonal antibodies on lethal mouse hepatitis virus infection in mice. J. Virol. 59:168.
22. Wesseling, J. G., G. J. Godeke, V. E. Schijns, L. Prevec, F. L. Graham, M. C. Horzinek, and P. J. Rottier. 1993. Mouse hepatitis virus spike and nucleocapsid proteins expressed by adenovirus vectors protect mice against a lethal infection. J. Gen. Virol. 74:2061.
23. Enjuanes, L., C. Sune, F. Gebauer, C. Smerdou, A. Camacho, I. M. Anton, S. Gonzalez, A. Talamillo, A. Mendez, M. L. Ballesteros, et al. 1992. Antigen selection and presentation to protect against transmissible gastroenteritis coronavirus. Vet. Microbiol. 33:249.
24. Gebauer, F., W. P. Posthumus, I. Correa, C. Sune, C. Smerdou, C. M. Sanchez, J. A. Lenstra, R. H. Meloen, and L. Enjuanes. 1991. Residues involved in the antigenic sites of transmissible gastroenteritis coronavirus S glycoprotein. Virology 183:225.
25. Posthumus, W. P., J. A. Lenstra, A. P. van Nieuwstadt, W. M. Schaaper, B. A. van der Zeijst, and R. H. Meloen. 1991. Immunogenicity of peptides simulating a neutralization epitope of transmissible gastroenteritis virus. Virology 182:371.
26. Li, G., X. Chen, and A. Xu. 2003. Profile of specific antibodies to the SARS-associated coronavirus. N. Engl. J. Med. 349:508.
27. Kolaskar, A. S., and P. C. Tongaonkar. 1990. A semi-empirical method for prediction of antigenic determinants on protein antigens. FEBS Lett. 276:172.
28. Lu, L., I. Manopo, B. P. Leung, H. H. Chng, A. E. Ling, L. L. Chee, E. E. Ooi, S. W. Chan, and J. Kwang. 2004. Immunological characterization of the spike protein of the severe acute respiratory syndrome coronavirus. J. Clin. Microbiol. 42:1570.
29. Wang, J., J. Wen, J. Li, J. Yin, Q. Zhu, H. Wang, Y. Yang, E. Qin, B. You, W. Li, et al. 2003. Assessment of immunoreactive synthetic peptides from the structural proteins of severe acute respiratory syndrome coronavirus. Clin. Chem. 49:1989.
30. Marshall, E., and M. Enserink. 2004. Medicine: caution urged on SARS vaccines. Science 303:944.
31. Jiang, S. B., K. Lin, and A. R. Neurath. 1991. Enhancement of human immunodeficiency virus type 1 infection by antisera to peptides from the envelope glycoproteins gp120/gp41. J. Exp. Med. 174:1557.
32. Ding, Y., H. Wang, H. Shen, Z. Li, J. Geng, H. Han, J. Cai, X. Li, W. Kang, D. Weng, et al. 2003. The clinical pathology of severe acute respiratory syndrome (SARS): a report from China. J. Pathol. 200:282.
33. Oba, Y. 2003. The use of corticosteroids in SARS. N. Engl. J. Med. 348:2034.
34. Wang, H., Y. Ding, X. Li, L. Yang, W. Zhang, and W. Kang. 2003. Fatal aspergillosis in a patient with SARS who was treated with corticosteroids. N. Engl. J. Med. 349:507.