Differential cytokine and antibody responses to adult and larval stages of Onchocerca volvulus consistent with the development of concomitant immunity

Infection and Immunity

Volumn 70, Issue 6, 2002, Pages 2796-2804

  MacDonald, Angus J ^a   Turaga, Prasad S D ^a   Harmon Brown, Carolyn ^a   Tierney, Tracy J ^a   Bennett, Kristine E ^a   McCarthy, Maggie C ^a   Simonek, Scott C ^a   Enyong, Peter A ^a   Moukatte, Daniel W ^a   Lustigman, Sara ^a  

^a NEW YORK BLOOD CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 5;

ANTIBODY RESPONSE; ARTICLE; CAMEROON; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; LYMPHOCYTE PROLIFERATION; MICROFILARIA; NONHUMAN; ONCHOCERCA VOLVULUS; ONCHOCERCIASIS; PRIORITY JOURNAL;

ADOLESCENT; ADULT; AGE FACTORS; ANIMALS; ANTIBODIES, HELMINTH; CELL DIVISION; CELLS, CULTURED; CHILD; CHILD, PRESCHOOL; FEMALE; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-5; LARVA; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTES; MALE; MIDDLE AGED; ONCHOCERCA VOLVULUS; ONCHOCERCIASIS; SKIN;

EID: 0036262990     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.70.6.2796-2804.2002     Document Type: Article

References (47)

1. Development of a recombinant antigen vaccine against infection with the filarial worm Onchocerca volvulus
2. Guatemalan human onchocerciasis. II. Evidence for IgG3 involvement in acquired immunity to Onchocerca volvulus and identification of possible immune-associated antigens
3. Differences in cytokine responses to Onchocerca volvulus extract and recombinant Ov33 and OvL3-1 proteins in exposed subjects with various parasitologic and clinical states
4. Immunologic aspects of schistosomiasis
5. Early human infection with Onchocerca volvulus is associated with an enhanced parasite-specific cellular immune response
6. The profile of IgG and IgG subclasses of onchocerciasis patients
7. Age-specific acquisition of immunity to infective larvae in a bancroftian filariasis endemic area of Papua New Guinea
8. The third-stage larva (L3) of Brugia: Its role in immune modulation and protective immunity
9. Production of both IFN-gamma and IL-5 by Onchocerca volvulus S1 antigen-specific CD4+ T cells from putatively immune individuals
10. Antigen-specific cellular hyporesponsiveness in a chronic human helminth infection is mediated by T(h)3/T(r)1-type cytokines IL-10 and transforming growth factor-beta but not by a T(h)1 to T(h)2 shift
11. The contributions of different age groups to the transmission of Onchocerciasis in a Cameroon forest village
12. Identification and characterization of a polysaccharide-containing antigen from Schistosoma mansoni eggs which cross-reacts with the surface of schistosomula
13. Protective immunity linked with a distinct developmental stage of a filarial parasite
14. Immunity to onchocerciasis: Putative immune persons produce a Th1-like response to Onchocerca volvulus
15. Immunity to onchocerciasis: Identification of a putatively immune population in a hyperendemic area of Ecuador
16. Antibody responses in onchocerciasis as a function of age and infection intensity
17. Cell-mediated immune responses in human infection with Onchocerca volvulus
18. Identification of recombinant filarial proteins capable of inducing polyclonal and antigen-specific IgE and IgG4 antibodies
19. Human granulocyte-macrophage colony-stimulating factor (GM-CSF): Regulation of expression
20. Immunoglobulin G subclass responses of children during infection with Onchocerca volvulus
21. Pathogenesis of onchocercal keratitis (River blindness)
22. Human antibody responses to Wuchereria bancrofti infective larvae
23. Control of allergic reactivity in human filariasis. Predominant localization of blocking antibody to the IgG4 subclass
24. Onchocerca volvulus: A comparative study of in vitro neutrophil killing of microfilariae and humoral responses in infected and endemic normals
25. Immune responses to third stage larvae of Onchocerca volvulus in interferon-gamma and interleukin-4 knockout mice
26. Characterization of an Onchocerca volvulus L3-specific larval antigen, Ov-ALT-1
27. Antibody responses to filarial infective larvae are not dominated by the IgG4 isotype
28. IL-4-and IL-5-dependent protective immunity to Onchocerca volvulus infective larvae in BALB/cBYJ mice
29. Adult and microfilarial stages of the filarial parasite Brugia malayi stimulate contrasting cytokine and Ig isotype responses in BALB/c mice
30. Animal models for the study of immunity in human filariasis
31. IL-4- and IL-5-secreting lymphocyte populations are preferentially stimulated by parasite-derived antigens in human tissue invasive nematode infections
32. Stage-specific induction of cytokines regulates the immune response in lymphatic filariasis
33. Immunological genomics of Brugia malayi: Filarial genes implicated in immune evasion and protective immunity
34. Immunological modulation and evasion by helminth parasites in human populations
35. Onchocerca volvulus: Application of the polymerase chain reaction to identification and strain differentiation of the parasite
36. A note on concomitant immunity in host-parasite relationships: A successfully transplanted concept from tumor immunology
37. Human onchocerciasis in Nigeria: Isotypic responses and antigen recognition in individuals with defined cutaneous pathology
38. NO contributes to proliferative suppression in a murine model of filariasis
39. Interleukin-10 and antigen-presenting cells actively suppress Th1 cells in BALB/c mice infected with the filarial parasite Brugia pahangi
40. Human isotype antibody responses to an Onchocerca volvulus glutathione S-transferase
41. Ivermectin-facilitated immunity in onchocerciasis. Reversal of lymphocytopenia, cellular anergy and deficient cytokine production after single treatment
42. The diverse expression of immunity in humans at distinct states of Onchocerca volvulus infection
43. Isotype-specific characterization of antibody responses to Onchocerca volvulus in putatively immune individuals
44. Onchocerciasis modulates the immune response to mycobacterial antigens
45. Heterogeneity of IgG antibody responses to cloned Onchocerca volvulus antigens in microfiladermia positive individuals from Esmeraldas Province
46. Immunity to onchocerciasis: Cells from putatively immune individuals produce enhanced levels of interleukin-5, gamma interferon, and granulocyte-macrophage colony-stimulating factor in response to Onchocerca volvulus larval and male worm antigens
47. Onchocerciasis and immunity in humans: Enhanced T-cell responsiveness to parasite antigen in putatively immune individuals