Phosphorous acid analogs of novel P2-P4 macrocycles as inhibitors of HCV-NS3 protease

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 9, 2009, Pages 2574-2578

  Pompei, Marco ^a   Francesco, Maria Emilia Di ^a   Koch, Uwe ^a   Liverton, Nigel J ^b   Summa, Vincenzo ^a  

^a Merck Research Laboratories   (Italy)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Bioisosteres; HCV; Hepatitis C; MK7009; NS3; Phosphonate; Protease inhibitor

Indexed keywords

CARBOXYLIC ACID; MACROCYCLIC COMPOUND; NS3 PROTEASE; PHOSPHORUS ACID DERIVATIVE; PHOSPHORUS DERIVATIVE; PROTEINASE; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; ASSAY; DRUG POTENCY; DRUG SYNTHESIS; HEPATITIS C VIRUS; INHIBITION KINETICS; PROTEINASE INHIBITION;

ANTIVIRAL AGENTS; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; ENZYME INHIBITORS; HEPATITIS C; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; MOLECULAR STRUCTURE; PHOSPHATES; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS;

EID: 64249120244     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.03.038     Document Type: Article

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