The synthesis and antiviral properties of acyclic nucleoside analogues with a phosphonomethoxy fragment in the side chain

Current Medicinal Chemistry

Volumn 13, Issue 24, 2006, Pages 2953-2980

  Khandazhinskaya, A ^a   Yasko, M ^a   Shirokova, Elena ^a  

^a ENGELHARDT INSTITUTE OF MOLECULAR BIOLOGY   (Russian Federation)

Author keywords

Acyclic nucleoside analogues; Antiviral properties; Phosphonomethoxy groups; Prodrugs

Indexed keywords

1' OXA 9 (3 HYDROXY 2 PHOSPHONOMETHOXYPROPYL)ADENINE; 2 (PHOSPHONOMETHOXY)PROPYL O 2,4 DIAMINOPYRIMIDINE; 2 PHOSPHONOMETHOXYETHYL O 2,4 DIAMINOPYRIMIDINE; 3 HYDROXY (2 PHOSPHONOMETHOXY)PROPYL O 2,4 DIAMINOPYRIMIDINE; 9 (2 METHYLIDENE 3 PHOSPHONOMETHOXYPROPYL)GUANINE; 9 (2,3 DIHYDROXYPROPYL)ADENINE; 9 (3 HYDROXY 2 PHOSPHONOMETHOXYPROPYL)ADENINE; 9 (3 HYDROXY 2 PHOSPHONOMETHOXYPROPYL)GUANINE; 9 [1 (PHOSPHONOMETHOXYCYCLOPROPYL)METHYL)]GUANINE; 9 [1 METHYL 2 (PHOSPHONOMETHOXY)ETHYL]GUANINE; 9 [2 (PHOSPHOMETHOXY)ETHOXY]ADENINE; ACICLOVIR; ACYCLIC NUCLEOSIDE; ADEFOVIR; ADEFOVIR DIPIVOXIL; ANTIRETROVIRUS AGENT; ANTIVIRUS AGENT; BIS(ISOPROPYLOXYCARBONYLOXYMETHYL) 9 (2 PHOSPHONOMETHOXYPROPHYL)ADENINE; BIS(PIVALOYLOXYMETHYL) 9 (2 PHOSPHONOMETHOXYETHYL)ADENINE; CIDOFOVIR; FOSCARNET; LAMIVUDINE; MB 06866Q; NUCLEOSIDE ANALOG; PLANT EXTRACT; PRODRUG; REMOFOVIR; REMOFOVIR MESYLATE; STRAWBERRY EXTRACT; TENOFOVIR; TENOFOVIR DISOPROXIL; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZIDOVUDINE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; CLINICAL TRIAL; DRUG ABSORPTION; DRUG ANTAGONISM; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG EFFICACY; DRUG MECHANISM; DRUG METABOLISM; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG UPTAKE; DRUG WITHDRAWAL; HEPATITIS B; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IC 50; NEPHROTOXICITY; NONHUMAN; REVIEW; SMALLPOX; TREATMENT DURATION;

ANIMALS; ANTI-HIV AGENTS; ANTIVIRAL AGENTS; HEPATITIS B VIRUS; HIV; HUMANS; NUCLEOSIDES; ORGANOPHOSPHORUS COMPOUNDS; PHOSPHONIC ACIDS; PRODRUGS;

EID: 33749447149     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986706778521896     Document Type: Review

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