Synthesis and antiviral activity of 2,4-diamino-5-cyano-6-[2- (phosphonomethoxy)ethoxy]pyrimidine and related compounds

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 12, 2004, Pages 3197-3202

  Hocková, Dana ^a   Holý, Antonín ^a   Masojídková, Milena ^a   Andrei, Graciela ^b   Snoeck, Robert ^b   De Clercq, Erik ^b   Balzarini, Jan ^b  

^a INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Acyclic nucleoside phosphonates; Antiviral; Nucleotide analogues; Pyrimidines

Indexed keywords

2,4 DIAMINO 5 CYANO 6 [2 (DIISOPROPOXYPHOSPHORYLMETHOXY)ETHOXY]PYRIMIDINE; 2,4 DIAMINO 5 CYANO 6 [2 (PHOSPHONOMETHOXY)ETHOXY]PYRIMIDINE; 2,4 DIAMINO 5 CYANO 6 [[(DIISOPROPOXYPHOSPHORYL)METHOXY]ETHOXY]PYRIMIDINE; 2,4 DIAMINO 5 CYANO 6 METHOXYPYRIMIDINE; 2,4 DIAMINO 5 FORMYL 6 [2 (DIISOPROPOXYPHOSPHORYLMETHOXY)ETHOXY]PYRIMIDINE; 2,4 DIAMINO 5 FORMYL 6 [2 (PHOSPHONOMETHOXY)ETHOXY]PYRIMIDINE; 2,4 DIAMINO 5 HYDROXYMETHYL 6 [2 (DIISOPROPOXYPHOSPHORYLMETHOXY)ETHOXY]PYRIMIDINE; 2,4 DIAMINO 6 HYDROXYPYRIMIDINE 5 CARBOXAMIDE; 5,5' METHYLENEBIS[2,4 DIAMINO 6 [2 (DIISOPROPOXYPHOSPHORYLMETHOXY)ETHOXY]PYRIMIDINE]; 5,5' METHYLENEBIS[2,4 DIAMINO 6 [2 (PHOSPHONOMETHOXY)ETHOXY]PYRIMIDINE]; ADEFOVIR; ANTIVIRUS AGENT; DIMER; PHOSPHONIC ACID DERIVATIVE; PYRIMIDINE DERIVATIVE; SILANE DERIVATIVE; TENOFOVIR; UNCLASSIFIED DRUG;

ALKYLATION; ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CHEMICAL MODIFICATION; CYCLIZATION; DRUG SYNTHESIS; EMBRYO; HUMAN; HUMAN CELL; HYDROLYSIS; MOUSE; NONHUMAN; REDUCTION;

ANIMALS; ANTIVIRAL AGENTS; CELL LINE; DNA VIRUSES; HIV; MICE; MOLECULAR STRUCTURE; PYRIMIDINES;

EID: 2542428468     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.04.002     Document Type: Article

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