SARS-CoV proteins decrease levels and activity of human ENaC via activation of distinct PKC isoforms

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 296, Issue 3, 2009, Pages

  Ji, Hong Long ^a,b   Song, Weifeng ^a   Gao, Zhiqian ^a   Su, Xue Feng ^c   Nie, Hong Guang ^b   Jiang, Yi ^c   Peng, Ji Bin ^c   He, Yu Xian ^d   Liao, Ying ^e   Zhou, Yong Jian ^f   Tousson, Albert ^c   Matalon, Sadis ^a,c  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF TEXAS HEALTH CENTER   (United States)

^c UNIVERSITY OF ALABAMA SCHOOL OF MEDICINE   (United States)

^d NEW YORK BLOOD CENTER   (United States)

^e NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^f GUANGZHOU FIRST PEOPLE'S HOSPITAL   (China)

Author keywords

Amiloride sensitive currents; Cell attached patches; H441 cells; Severe acute respiratory syndrome coronavirus; Surface epithelial sodium channels; Voltage clamp; Xenopus oocytes

Indexed keywords

AMILORIDE; CORONAVIRUS PROTEIN E; CORONAVIRUS PROTEIN S; EPITHELIAL SODIUM CHANNEL; EPITHELIAL SODIUM CHANNEL ALPHA; EPITHELIAL SODIUM CHANNEL BETA; EPITHELIAL SODIUM CHANNEL GAMMA; PROTEIN KINASE C; PROTEIN KINASE C ALPHA; PROTEIN KINASE C BETA; PROTEIN KINASE C BETA1; PROTEIN KINASE C LAMBDA; UNCLASSIFIED DRUG; VIRUS PROTEIN; E PROTEIN, SARS CORONAVIRUS; ISOENZYME; MEMBRANE PROTEIN; PROTEIN KINASE INHIBITOR; RECOMBINANT PROTEIN; SPIKE GLYCOPROTEIN, CORONAVIRUS; VIRUS ENVELOPE PROTEIN;

ANIMAL CELL; ARTICLE; CELL SURFACE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HYDROPHILICITY; LUNG ALVEOLUS EPITHELIUM; LUNG EDEMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RESPIRATORY EPITHELIUM; SARS CORONAVIRUS; SODIUM TRANSPORT; VOLTAGE CLAMP; XENOPUS; ACUTE LUNG INJURY; ANIMAL; CELL LINE; DRUG ANTAGONISM; ENDOCYTOSIS; EXOCYTOSIS; FEMALE; GENE EXPRESSION; GENETIC TRANSFECTION; GENETICS; IN VITRO STUDY; METABOLISM; OOCYTE; PATCH CLAMP; PATHOGENICITY;

ACUTE LUNG INJURY; AMILORIDE; ANIMALS; CELL LINE; ENDOCYTOSIS; ENZYME ACTIVATION; EPITHELIAL SODIUM CHANNEL; EXOCYTOSIS; FEMALE; GENE EXPRESSION; HUMANS; ISOENZYMES; MEMBRANE GLYCOPROTEINS; OOCYTES; PATCH-CLAMP TECHNIQUES; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; PULMONARY EDEMA; RECOMBINANT PROTEINS; SARS VIRUS; TRANSFECTION; VIRAL ENVELOPE PROTEINS; VIRAL PROTEINS; XENOPUS;

EID: 64249092901     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.90437.2008     Document Type: Article

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