Leflunomide prevents alveolar fluid clearance inhibition by respiratory syncytial virus

American Journal of Respiratory and Critical Care Medicine

Volumn 173, Issue 6, 2006, Pages 673-682

  Davis, Ian C ^b   Lazarowski, Eduardo R ^b   Hickman Davis, Judy M ^b   Fortenberry, James A ^b   Chen, Fu Ping ^b   Zhao, Xiaodong ^b   Sorscher, Eric ^b   Graves, Lee M ^b   Sullender, Wayne M ^b   Matalon, Sadis ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b NONE

Author keywords

Ion transport; Paramyxovirus infections; Pneumonia; Pulmonary edema; Viral

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANION CHANNEL; BOVINE SERUM ALBUMIN; LEFLUNOMIDE; MERCAPTOPURINE; NUCLEOTIDE; URIDINE TRIPHOSPHATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD CELL COUNT; BLOOD OXYGENATION; DISEASE COURSE; EDEMA; FEMALE; HYPOXEMIA; LUNG FLUID; LUNG LAVAGE; MALE; MOUSE; NONHUMAN; POTENTIAL DIFFERENCE; PRIORITY JOURNAL; PYRIMIDINE SYNTHESIS; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; VIRUS INFECTION; VIRUS REPLICATION; VIRUS STRAIN;

ANIMALS; ANTIVIRAL AGENTS; BRONCHOALVEOLAR LAVAGE FLUID; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; FEMALE; ISOXAZOLES; LUNG; MALE; MICE; MICE, INBRED BALB C; NUCLEOTIDASES; PNEUMONIA, VIRAL; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; RESPIRATORY SYNCYTIAL VIRUSES; SEVERITY OF ILLNESS INDEX;

EID: 33644844642     PISSN: 1073449X     EISSN: 1073449X     Source Type: Journal    
DOI: 10.1164/rccm.200508-1200OC     Document Type: Article

References (54)

1. Sartori C, Matthay MA. Alveolar epithelial fluid transport in acute lung injury: new insights. Eur Respir J 2002;20:1299-1313.
2. Ware LB, Matthay MA. Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome. Am J Respir Crit Care Med 2001;163:1376-1383.
3. Black CP. Systematic review of the biology and medical management of respiratory syncytial virus infection. Respir Care 2003;48:209-233.
4. Davis IC, Sullender WM, Hickman-Davis JM, Lindsey JR, Matalon S. Nucleotide-mediated inhibition of alveolar fluid clearance in BALB/c mice after respiratory syncytial virus infection. Am J Physiol Lung Cell Mol Physiol 2004;286:L112-L120.
5. Davis IC, Sullender WM, Graves LM, Zhao X, Matalon S. Respiratory syncytial virus inhibits alveolar fluid clearance by inducing release of de novo-synthesized UTP [abstract 684.3]. FASEB J 2004;18.
6. Davis IC, Sullender WM, Graves LM, Zhao X, Matalon S. Pyrimidine biosynthesis and release mechanism in respiratory syncytial virus-induced inhibition of alveolar fluid clearance [abstract]. Am J Respir Crit Care Med 2004;169:A669.
7. Smee DF, Bailey KW, Wong MH, Sidwell RW. Effects of cidofovir on the pathogenesis of a lethal vaccinia virus respiratory infection in mice. Antiviral Res 2001;52:55-62.
8. - secretion in nasal epithelia of CF mice. Am J Physiol 1994;266:C1478-C1483.
9. Lazarowski ER, Harden TK. Quantitation of extracellular UTP using a sensitive enzymatic assay. Br J Pharmacol 1999;127:1272-1278.
10. Drabkin DL. Heme binding and transport: a spectrophotometric study of plasma glycoglobulin hemochromogens. Proc Natl Acad Sci USA 1971;68:609-613.
11. Pinschewer DD, Ochsenbein AF, Fehr T, Zinkernagel RM. Leflunomide-mediated suppression of antiviral antibody and T cell responses: differential restoration by uridine. Transplantation 2001;72:712-719.
12. -/- mice. Mol Pharmacol 2003;64:456-465.
13. Hickman-Davis JM, Lindsey JR, Matalon S. Cyclophosphamide decreases nitrotyrosine formation and inhibits nitric oxide production by alveolar macrophages in mycoplasmosis. Infect Immun 2001;69:6401-6410.
14. Hickman-Davis JM, Gibbs-Erwin J, Lindsey JR, Matalon S. Role of surfactant protein-A in nitric oxide production and mycoplasma killing in congenic C57BL/6 mice. Am J Respir Cell Mol Biol 2004;30:319-325.
15. Schlapfer E, Fischer M, Ott P, Speck RF. Anti-HIV-1 activity of leflunomide: a comparison with mycophenolic acid and hydroxyurea. AIDS 2003;17:1613-1620.
16. Knight DA, Hejmanowski AQ, Dierksheide JE, Williams JW, Chong AS, Waldman WJ. Inhibition of herpes simplex virus type 1 by the experimental immunosuppressive agent leflunomide. Transplantation 2001;71:170-174.
17. Waldman WJ, Knight DA, Lurain NS, Miller DM, Sedmak DD, Williams JW, Chong AS. Novel mechanism of inhibition of cytomegalovirus by the experimental immunosuppressive agent leflunomide. Transplantation 1999;68:814-825.
18. Graham BS, Perkins MD, Wright PF, Karzon DT. Primary respiratory syncytial virus infection in mice. J Med Virol 1988;26:153-162.
19. + cytotoxic-T-lymphocyte response and viral clearance in mice with primary respiratory syncytial virus infection. J Virol 2004;78:3014-3023.
20. Hardiman KM, Lindsey JR, Matalon S. Modulation of active ion transport by nitric oxide in hyperoxia. Am J Physiol Lung Cell Mol Physiol 2001;281:L722-L731.
21. + transport by basal nitric oxide. Am J Respir Cell Mol Biol 2004;30:720-728.
22. Okada SF, O'Neal WK, Huang P, Nicholas RA, Ostrowski LE, Craigen WJ, Lazarowski ER, Boucher RC. Voltage-dependent anion channel-1 (VDAC-1) contributes to ATP release and cell volume regulation in murine cells. J Gen Physiol 2004;124:513-526.
23. Nilius B, Eggermont J, Droogmans G. The endothelial volume-regulated anion channel, VRAC. Cell Physiol Biochem 2000;10:313-320.
24. - channels expressed in a murine cell line. J Physiol 1997;503:333-346.
25. - channels in Xenopus oocytes. Mol Pharmacol 1990;37:720-724.
26. Lazarowski ER, Boucher RC, Harden TK. Mechanisms of release of nucleotides and integration of their action as P2X- and P2Y-receptor activating molecules. Mol Pharmacol 2003;64:785-795.
27. Joseph SM, Buchakjian MR, Dubyak GR. Colocalization of ATP release sites and ecto-ATPase activity at the extracellular surface of human astrocytes. J Biol Chem 2003;278:23331-23342.
28. Lazarowski ER, Tarran R, Grubb BR, Van Heusden CA, Okada S, Boucher RC. Nucleotide release provides a mechanism for airway surface liquid homeostasis. J Biol Chem 2004;279:36855-36864.
29. Donaldson SH, Lazarowski ER, Picher M, Knowles MR, Stutts MJ, Boucher RC. Basal nucleotide levels, release, and metabolism in normal and cystic fibrosis airways. Mol Med 2000;6:969-982.
30. Lazarowski ER, Homolya L, Boucher RC, Harden TK. Direct demonstration of mechanically induced release of cellular UTP and its implication for uridine nucleotide receptor activation. J Biol Chem 1997;272:24348-24354.
31. - transport. J Biol Chem 1999;274:26461-26468.
32. Fairbanks LD, Bofill M, Ruckemann K, Simmonds HA. Importance of ribonucleotide availability to proliferating T-lymphocytes from healthy humans: disproportionate expansion of pyrimidine pools and contrasting effects of de novo synthesis inhibitors. J Biol Chem 1995;270:29682-29689.
33. Di Virgilio F, Chiozzi P, Ferrari D, Falzoni S, Sanz JM, Morelli A, Torboli M, Bolognesi G, Baricordi OR. Nucleotide receptors: an emerging family of regulatory molecules in blood cells. Blood 2001;97:587-600.
34. Kunzelmann K, Konig J, Sun J, Markovich D, King NJ, Karupiah G, Young JA, Cook DI. Acute effects of parainfluenza virus on epithelial electrolyte transport. J Biol Chem 2004;279:48760-48766.
35. Huang M, Graves LM. De novo synthesis of pyrimidine nucleotides: emerging interfaces with signal transduction pathways. Cell Mol Life Sci 2003;60:321-336.
36. Davis JP, Cain GA, Pitts WJ, Magolda RL, Copeland RA. The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase. Biochemistry 1996;35:1270-1273.
37. Rezaiguia S, Garat C, Delclaux C, Meignan M, Fleury J, Legrand P, Matthay MA, Jayr C. Acute bacterial pneumonia in rats increases alveolar epithelial fluid clearance by a tumor necrosis factor-α-dependent mechanism. J Clin Invest 1997;99:325-335.
38. Galietta LJ, Folli C, Marchetti C, Romano L, Carpani D, Conese M, Zegarra-Moran O. Modification of transepithelial ion transport in human cultured bronchial epithelial cells by interferon-γ. Am J Physiol Lung Cell Mol Physiol 2000;278:L1186-L1194.
39. Fukuda N, Jayr C, Lazrak A, Wang Y, Lucas R, Matalon S, Matthay MA. Mechanisms of TNF-α stimulation of amiloride-sensitive sodium transport across alveolar epithelium. Am J Physiol Lung Cell Mol Physiol 2001;280:L1258-L1265.
40. Galietta LJ, Pagesy P, Folli C, Caci E, Romio L, Costes B, Nicolis E, Cabrini G, Goossens M, Ravazzolo R, et al. IL-4 is a potent modulator of ion transport in the human bronchial epithelium in vitro. J Immunol 2002;168:839-845.
41. Xu X, Shen J, Mall JW, Myers JA, Huang W, Blinder L, Saclarides TJ, Williams JW, Chong AS. In vitro and in vivo antitumor activity of a novel immunomodulatory drug, leflunomide: mechanisms of action. Biochem Pharmacol 1999;58:1405-1413.
42. Brooks AM, McBride JT, McConnochie KM, Aviram M, Long C, Hall CB. Predicting deterioration in previously healthy infants hospitalized with respiratory syncytial virus infection. Pediatrics 1999;104:463-467.
43. Knowles MR, Paradiso AM, Boucher RC. In vivo nasal potential difference: techniques and protocols for assessing efficacy of gene transfer in cystic fibrosis. Hum Gene Ther 1995;6:445-455.
44. Alton EW, Currie D, Logan-Sinclair R, Warner JO, Hodson ME, Geddes DM. Nasal potential difference: a clinical diagnostic test for cystic fibrosis. Eur Respir J 1990;3:922-926.
45. Hofmann T, Bohmer O, Huls G, Terbrack HG, Bittner P, Klingmuller V, Heerd E, Lindemann H. Conventional and modified nasal potential-difference measurement in cystic fibrosis. Am J Respir Crit Care Med 1997;155:1908-1913.
46. Knowles MR, Carson JL, Collier AM, Gatzy JT, Boucher RC. Measurements of nasal transepithelial electric potential differences in normal human subjects in vivo. Am Rev Respir Dis 1981;124:484-490.
47. Wilson R, Alton E, Rutman A, Higgins P, Al Nakib W, Geddes DM, Tyrrell DA, Cole PJ. Upper respiratory tract viral infection and mucociliary clearance. Eur J Respir Dis 1987;70:272-279.
48. Schwiebert EM. ATP release mechanisms, ATP receptors and purinergic signalling along the nephron. Clin Exp Pharmacol Physiol 2001;28:340-350.
49. Huang P, Lazarowski ER, Tarran R, Milgram SL, Boucher RC, Stutts MJ. Compartmentalized autocrine signaling to cystic fibrosis transmembrane conductance regulator at the apical membrane of airway epithelial cells. Proc Natl Acad Sci USA 2001;98:14120-14125.
50. Marriott I, Inscho EW, Bost KL. Extracellular uridine nucleotides initiate cytokine production by murine dendritic cells. Cell Immunol 1999;195:147-156.
51. Idzko M, Panther E, Bremer HC, Sorichter S, Luttmann W, Virchow CJ Jr, Di Virgilio F, Herouy Y, Norgauer J, Ferrari D. Stimulation of P2 purinergic receptors induces the release of eosinophil cationic protein and interleukin-8 from human eosinophils. Br J Pharmacol 2003;138:1244-1250.
52. + T cells. Immunity 2001;15:637-646.
53. Schwarze J, Cieslewicz G, Joetham A, Ikemura T, Hamelmann E, Gelfand EW. CD8 T cells are essential in the development of respiratory syncytial virus-induced lung eosinophilia and airway hyperresponsiveness. J Immunol 1999;162:4207-4211.
54. 2- adrenergic receptors: their role in regulation of alveolar active sodium transport. Am J Respir Crit Care Med 2004;170:1270-1275.