Actin and Vimentin proteins with N-terminal deletion detected in tumor-bearing rat livers induced by intraportal-vein injection of Ha-ras-transfected rat liver cells

International Journal of Cancer

Volumn 124, Issue 11, 2009, Pages 2512-2519

  Nakamura, Yasushi ^a   Kominami, Akari ^a   Tsujimoto, Yoshiyuki ^a   Nakayama, Yuko ^a   Kitahashi, Tsukasa ^a   Yoshimoto, Sonoko ^a   Kubo, Asuka ^a   Watanabe, Shinpei ^a   Kageyama, Minami ^a   Yokoyama, Meiko ^a   Kido, Yasuhiro ^a   Kobayashi, Yukiko ^a   Kuwahata, Masashi ^a   Chang, Chia Cheng ^b,c   Upham, Brad L ^b,c   Trosko, James E ^b,c   Eun, Young Park ^a   Sato, Kenji ^a  

^a KYOTO PREFECTURAL UNIVERSITY   (Japan)

^b MICHIGAN STATE UNIVERSITY   (United States)

^c MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

Gap junctional intercellular communication; Liver; ras oncogene; Tumor; Vimentin

Indexed keywords

ACTIN; BETA ACTIN; CONNEXIN 43; GLUCOSE REGULATED PROTEIN 78; HEAT SHOCK PROTEIN 60; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; RAS PROTEIN; VIMENTIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BETA CHAIN; CELL COMMUNICATION; CHROMOSOME DELETION 4; CONTROLLED STUDY; DOWN REGULATION; GAP JUNCTION; GENETIC TRANSFECTION; IMMUNOBLOTTING; IN VIVO STUDY; ISOELECTRIC FOCUSING; LIVER CELL; LIVER TUMOR; MALE; NONHUMAN; ONCOGENE H RAS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RAT; SEQUENCE ANALYSIS; SHAM PROCEDURE; TWO DIMENSIONAL GEL ELECTROPHORESIS; UPREGULATION; ANIMAL; CELL JUNCTION; CELL LINE; CHEMISTRY; CYTOCHEMISTRY; ECHOGRAPHY; FISCHER 344 RAT; LIVER; ONCOGENE RAS; PHYSIOLOGY; PORTAL VEIN;

ACTINS; ANIMALS; CELL COMMUNICATION; CELL LINE; CONNEXIN 43; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; GAP JUNCTIONS; GENES, RAS; HISTOCYTOCHEMISTRY; LIVER; LIVER NEOPLASMS; MALE; PORTAL VEIN; RATS; RATS, INBRED F344; TRANSFECTION; VIMENTIN;

EID: 64249085555     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.24229     Document Type: Article

References (50)

1. World Health Organization, Fact sheet No. 297, February 2006. Available from: http://www.who.int/mediacentre/factsheets/fs297/en/print.html.
2. Staib F, Hussain SP, Hofseth LJ, Wang XW, Harris CC. TP53 and liver carcinogenesis. Hum Mutat 2003;21:201-216 (Pubitemid 36292963)
3. Nakamura Y, Trosko JE, Chang C-C, Upham BL. Psyllium extracts decreased neoplastic phenotypes induced by the Ha-ras oncogene transfected into a rat liver oval cell line. Cancer Lett 2004;203:13-24. (Pubitemid 37506079)
4. Upham BL, Wagner JG. Toxicological highlight: toxicant induced oxidative stress in cancer. Toxicol Sci 2001;64:1-3.
5. Trosko JE, Ruch RJ. Cell-cell communication in carcinogenesis. Front Biosci 1998;3:208-236
6. Rummel AM, Trosko JE, Wilson MR, Upham BL. Polycyclic aromatic hydrocarbons with bay-like regions inhibited gap junctional intercellular communication and stimulated MAPK activity. Toxicol Sci 1999;49:232-240 (Pubitemid 29300409)
7. Trosko JE, Ruch RJ. Gap junctions as targets for cancer chemoprevention and chemotherapy. Curr Drug Targets 2002;3:465-482 (Pubitemid 35339336)
8. Yamasaki H, Krutovskikh V, Mesnil M, Tanaka T, Zaidan DM, Omori Y. Role of connexin (gap junction) genes in cell growth control and carcinogenesis. C R Acad Sci III 1999;322:151-159
9. de-Feijter AW, Ray JS, Weghorst CM, Klaunig JE, Goodman JI, Chang CC, Ruch RJ, Trosko JE. Infection of rat liver epithelial cells with v-Ha-ras: correlation between oncogene expression, gap junctional communication, and tumorigenicity.Mol Carcinog 1990;3:54-67.
10. de-Feijter AW, Trosko JE, Krizman DB, Lebovitz RM, Lieberman MW. Correlation of increased levels of Ha-ras T24 protein with extent of loss of gap junction function in rat liver epithelial cells. Mol Carcinog 1992;5:205-212
11. de-Feijter AW, Matesic DF, Ruch RJ, Guan X, Chang CC, Trosko JE. Localization and function of the connexin 43 gap-junction protein in normal and various oncogene-expressing rat liver epithelial cells. Mol Carcinog 1996;16:203-212
12. Dotto GP, El-Fouly MH, Nelson C, Trosko JE. Similar and synergistic inhibition of gap-junctional communication by ras transformation and tumor promoter treatment of mouse primary keratinocytes. Oncogene 1989;4:637-641 (Pubitemid 19139717)
13. El-Fouly MH, Trosko JE, Chang CC, Warren ST. Potential role of the human Ha-ras oncogene in the inhibition of gap junctional intercellular communication. Mol. Carcinog 1989;2:131-135 (Pubitemid 19252237)
14. Hayashi T, Nomata K, Chang CC, Ruch RJ, Trosko JE. Cooperative effects of v-myc and c-Ha-ras oncogenes on gap junctional intercellular communication and tumorigenicity in rat liver epithelial cells. Cancer Lett 1998;128:145-154 (Pubitemid 28318728)
15. Hotz WA, Shalloway D. Gap junctional communication and neoplastic transformation. Crit Rev Oncog 1993;4:541-558
16. Vanhamme L, Rolin S, Szpirer C. Inhibition of gap-junctional intercellular communication between epithelial cells transformed by the activated H-ras-1 oncogene. Exp Cell Res 1989;180:297-301. (Pubitemid 19031029)
17. Chen X, Shuzo O, Li Y, Han R. Effect of d-limonene. Salvia miltiorrhiza and turmeric derivatives on membrane association of. Ras gene product and gap junction intercellular communication. Yao Xue Xue Bao 1998;33:821-827
18. Mehta PP, Bertram JS, Loewenstein WR. Growth inhibition of transformed cells correlates with their junctional communication with normal cells. Cell 1986;44:187-196 (Pubitemid 16036726)
19. Mehta PP, Bertram JS, Loewenstein WR. The action of retinoids on cellular growth correlate with their actions on gap junction communication. J Cell Biol 1989;108:1053-1065 (Pubitemid 19083750)
20. Cesen-Cummings K, Warner KA, Ruch RJ. Role of protein kinase C in the deficient gap junctional intercellular communication of K-ras-transformed murine lung epithelial cells. Anticancer Res 1998;18:4343-4346 (Pubitemid 29043657)
21. Azarnia R, Russell TR. Cyclic AMP effects on cell-to-cell junctional membrane permeability during adipocyte differentiation of 3T3-L1 fibroblasts. J Cell Biol 1985;100:265-269 (Pubitemid 15151902)
22. Flagg-Newton JL, Dahl G, Loewenstein WR. Cell junction and cyclic AMP, Part 1. Upregulation of junctional membrane permeability and junctional membrane particles by administration of cyclic nucleotide or phosphodiesterase inhibitor. J Membr Biol 1981;63:105-121 (Pubitemid 12221319)
23. Veld PI, Schuit F, Pipeleers D. Gap junctions between pancreatic B-cells are modulated by cyclic AMP. Eur J Cell Biol 1985;36:269-276 (Pubitemid 15121299)
24. Hossain M, Loewenstein WR, Mehta PP, Bertram JS. Enhancement of junctional communication by retinoids correlates with their effects on transformation in C3H10T1/2Cl8 cells. Carcinogenesis 1989;10:1743-1748 (Pubitemid 19222280)
25. Zhang LX, Cooney RV, Bertram JS. Carotenoids enhance gap junctional communication and inhibit lipid peroxidation in C3H/10T1/2 cells: relationship to their cancer chemopreventive action. Carcinogenesis 1991;12:2109-2114
26. Zhang LX, Cooney RV, Bertram JS. Carotenoids up-regulate connexin43 gene expression independent of their provitamin A or antioxidant properties. Cancer Res 1992;52:5707-5712
27. Sigler K, Ruch RJ. Enhancement of gap junctional intercellular communication in tumor promoter-treated cells by components of green tea. Cancer Lett 1993;69:15-19 (Pubitemid 23135625)
28. Sai K, Kanno J, Hasegawa R, Trosko JE, Inoue T. Prevention of the down-regulation of gap junctional intercellular communication by green tea in the liver of mice fed pentachlorophenol. Carcinogenesis 2000;21:1671-1676
29. Huard C, Druesne N, Guyonnet D, Thomas M, Pagniez A, Le Bon AM, Martel P, Chaumontet C. Diallyl disulfide (DADS) enhances gap-junctional intercellular communication by both direct and indirect mechanisms in rat liver cells. Carcinogenesis 2004;25:91-98 (Pubitemid 38139227)
30. Nakamura Y, Yoshikawa N, Hiroki I, Sato K, Ohtsuki K, Chang C-C, Upham BL, Trosko JE. b-Sitosterol from psyllium seed husk (Plantago ovata Forsk) restores gap junctional intercellular communication in Ha-ras transfected rat liver cells. Nutr Cancer 2005;51:218-225 (Pubitemid 40734722)
31. Na HK, Wilson MR, Kang KS, Chang CC, Grunberger D, Trosko JE. Restoration of gap junctional intercellular communication by caffeic acid phenylethyl ester (CAPE) in a ras-transformed rat liver epithelial cell line. Cancer Lett 2000;157:31-38 (Pubitemid 30421228)
32. Tsao MS, Smith JD, Nelson KG, Grisham JW. A diploid epithelial cell line from normal adult rat liver with phenotypic properties of oval cells. Exp Cell Res 1984;154:38-52. (Pubitemid 14006407)
33. Trosko JE, Chang C-C, Wilson MR, Upham BL, Hayashi T, Wade M. Gap junctions and the regulation of cellular function of stem cells during development and differentiation. Methods 2000;20:245-264 (Pubitemid 30130816)
34. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970;227:680-685
35. Upham BL, Kang KS, Cho HY, Trosko JE. Hydrogen peroxide inhibits gap junctional intercellular communication in glutathione sufficient but not glutathione deficient cells. Carcinogenesis 1997;18:37-42. (Pubitemid 28134614)
36. O'Farrell PH. High resolution two-dimensional electrophoresis of proteins. J Biol Chem 1975;250:4007-4021
37. Tsujimoto Y, Taguchi N, Hirooka K, Tomari N, Okami A, Nishikawa T, Nakazawa Y, Watanabe K, Matsui H, Yamamoto Y. Comparison of solubilization and preparation procedures for membrane-enriched proteome analysis. J Electrophor 2007;51:15-20.
38. Gutkind JS. Cell growth control by G protein-coupled receptors: from signal transduction to signal integration. Oncogene 1998;17:1331-1342 (Pubitemid 28458403)
39. Bar-Sagi D, Hall A. Ras and Rho GTPases: a family reunion. Cell 2000;103:227-238
40. Boilard M, Reyes-Moreno C, Lachance C, Massicotte L, Bailey JL, Sirard M-A, Leclerc P. Localization of the chaperone proteins GRP78 and Hsp60 on the luminal surface of bovine oviduct epithelial cells and their association with spermatozoa. Biol Reprod 2004;71:1879-1889 (Pubitemid 39586932)
41. Fella K, Glückmann M, Hellmann J, Karas M, Kramer PJ, Kröger M. Use of two-dimensional gel electrophoresis in predictive toxicology: identification of potential early protein biomarkers in chemically induced hepatocarcinogenesis. Proteomics 2005;7:1914-1927 (Pubitemid 40686236)
42. Hirano J, Kita K, Sugaya S, Ichimura Y, Yamamori H, Nakajima N, Suzuki N. Down-regulation of molecular chaperone 78-kd glucose-regulated protein/immunoglobulin-binding protein expression involved in enhancement of human RS cell mutability. Pancreas 2008;36:7-14.
43. Martinez LO, Jacquet S, Esteve J-P, Rolland C, Cabezón E, Champagne E, Pineau T, Georgeaud V, Walker JE, Tercé F, Collet X, Perret B, Barbaras R. Ectopic b-chain of ATP synthase is an apolipoprotein A-I receptor in hepatic HDL endocytosis. Nature 2003;421:75-79 (Pubitemid 36077087)
44. Yoon WH, Song IS, Lee BH, Jung YJ, Kim TD, Li G, Lee TG, Park HD, Lim K, Hwang BD. Differential regulation of vimentin mRNA by 12-O-tetradecanoylphorbol 13-acetate and all-trans-retinoic acid correlates with motility of Hep 3B human hepatocellular carcinoma cells. Cancer Lett 2004;203:99-105. (Pubitemid 37506089)
45. Aigner T, Loos S, Müller S, Sandell LJ, Unni KK, Kirchner T. Cell differentiation and matrix gene expression in mesenchymal chondrosarcomas. Am J Pathol 2000;156:1327-1335. (Pubitemid 30662075)
46. Alison M, Golding M, Lalani EN, Nagy P, Thorgeirsson S, Sarraf C. Wholesale hepatocytic differentiation in the rat from ductular oval cells, the progeny of biliary stem cells. J Hepatol 1997;26:343-352 (Pubitemid 27077434)
47. Ruch RJ. Role of gap junctions in cellular growth control and neoplasia: evidence and mechanisms. In: Peracchia C, ed. Gap junctions - molecular basis of cell communication in health. San Diego: Academic Press, 2000;535-554
48. Ruch RJ, Hanna EA, Boucher PD, Fanning JD, Shewach DS. Gap junctional intercellular communication in human ovarian cancer. Proc Am Assoc Cancer Res 2000;41:163.
49. Trosko JE, Goodman JI. Intercellular communication may facilitate apoptosis: implications for tumor promotion. Mol Carcinog 1994;11:8-12. (Pubitemid 24337379)
50. Ogawa T, Hayashi T, Tokunou M, Nakachi K, Trosko JE, Chang CC, Yorioka N. Suberoylanilide hydroxamic acid enhances gap junctional intercellular communication via acetylation of histone containing connexin 43 gene locus. Cancer Res 2005;65:9771-9778 (Pubitemid 41541454)