Cooperative effects of v-myc and c-Ha-ras oncogenes on gap junctional intercellular communication and tumorigenicity in rat liver epithelial cells

Cancer Letters

Volumn 128, Issue 2, 1998, Pages 145-154

  Hayashi, Tomonori ^a   Nomata, Koichiro ^a   Chang, Chia Cheng ^a   Ruch, Randall J ^b   Trosko, James E ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b MEDICAL COLLEGE OF OHIO   (United States)

Author keywords

c Ha ras; Connexin 43; Gap junctional intercellular communication (GJIC); Rat liver epithelial cell; Tumorigenicity; v myc

Indexed keywords

ANIMAL CELL; ARTICLE; CARCINOGENICITY; CELL COMMUNICATION; EPITHELIUM CELL; FLUORESCENCE ANALYSIS; GAP JUNCTION; GENETIC TRANSFECTION; LIVER CELL; NONHUMAN; ONCOGENE MYC; ONCOGENE RAS; PRIORITY JOURNAL; RAT;

ANIMALS; CELL COMMUNICATION; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; EPITHELIAL CELLS; GAP JUNCTIONS; GENE EXPRESSION; GENES, MYC; GENES, RAS; LIVER; MALE; PROTO-ONCOGENE PROTEINS C-MYC; RAS PROTEINS; RATS; RATS, INBRED F344;

ANIMALIA;

EID: 0032547130     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(98)00060-3     Document Type: Article

References (54)

1. Land H., Parada L., Weinberg R. Tumorigenic conversion of primary embryo fibroblast requires at least two cooperating oncogenes. Nature. 304:1983;596-602.
2. Lee W., Schwab M.F., Westaway D., Varmus H.E. Augmented expression of the normal c-myc is sufficient for cotransformants of rat embryo cells with a mutant ras gene. Mol. Cell. Biol. 5:1985;3345-3356.
3. Yancopoulous G.D., Nisen P.D., Tesfaye A., Kohl N.E., Goldfarb M.P., Alt F.W. N-myc can cooperate with ras to transform normal cells in culture. Proc. Natl. Acad. Sci. USA. 82:1985;5455-5459.
4. Spandido D., Lang J. Immunomortalization by truncated myc or by ras genes and synergism between myc and ras genes and cell transformation. Anticancer Res. 9:1989;1149-1152.
5. Birrer M.J., Segal S., DeGreve J.S., Kaye F., Sausville E.A., Minna J.D. L-myc cooperates with ras to transform primary embryo fibroblasts. Mol. Cell. Biol. 8:1988;2668-2673.
6. Storer R.D., Allen H.L., Kraynak A.R., Bradley M.O. Rapid induction of an experimental metastatic phenotype in first passage rat embryo cells by cotransfection of EJ c-Ha-ras and c-myc oncogenes. Oncogene. 2:1988;141-147.
7. Richards C.A., Short S.A., Thorgeirsson S.S., Huber B.E. Characterization of a transforming N-ras gene in the human hepatoma cell line Hep G2: additional evidence for the importance of c-myc and ras cooperation in hepatocarcinogenesis. Cancer Res. 50:1990;1521-1527.
8. Schwartz R.C., Stanton L.W., Riley S.C., Marcu K.B., Witte O.N. Synergism of v-myc and v-Ha-ras in the in vitro neoplastic progression of murine lymphoid cells. Mol. Cell. Biol. 6:1986;3221-3231.
9. Hsiao W.L.W., Gattoni-Celli S., Weinstein I.B. Oncogene-induced transformation of C3H 10T1/2 cells is enhanced by tumor promoters. Science. 226:1984;552-554.
10. Dotto G.P., Parada L.F., Weinberg R.A. Specific growth response of ras-transformed embryo fibroblast to tumor promoters. Nature. 318:1985;472-475.
11. J.E. Trosko, C.C. Chang, B.V. Madhukar, E. Dupont, Oncogenes, tumor suppressor genes and intercellular communication in the 'Ontogeny as partially-blocked ontogeny' hypothesis, in: O.H. Iversen (Ed.), New Frontiers in Cancer Causation, Taylor and Francis, Washington, DC, 1993, pp. 181-197.
12. de Feijter A.W., Matesic D.F., Ruch R.J., Guan X., Chang C.C., Trosko J.E. Localization and function of the connexin 43 gap-junction protein in normal and various oncogene-expressing rat liver epithelial cells. Mol. Carcinogen. 16:1996;203-212.
13. Ruch R.J. The role of gap junctional intercellular communication in neoplasia. Ann. Clin. Lab. Sci. 24:1994;216-231.
14. J.E. Trosko, C.C. Chang, Nongenotoxic mechanisms in carcinogenesis: role of inhibited intercellular communication, in: R.W. Hart, F.G. Hoerger (Eds.), Banbury Report 31, Carcinogen Risk Assessment, New Directions in the Qualitative and Quantitative Aspects, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1988, pp. 139-170.
15. Bursch F., Oberhammer F., Schulte-Hermann R. Cell death by apoptosis and its protective role against disease. Trends Pharmacol. Sci. 13:1992;245-251.
16. Trosko J.E., Goodman J.A. Intercellular communication may facilitate apoptosis: implications for tumor promotion. Mol. Carcinogen. 11:1994;8-12.
17. Yotti L.P., Trosko J.E., Chang C.C. Elimination of metabolic cooperation in Chinese hamster cells by a tumor promoter. Science. 206:1979;1089-1091.
18. Murray A.W., Fitzgerald D.J. Tumor promoters inhibit metabolic cooperation in cocultures of epidermal and 3T3 cells. Biochem. Biophys. Res. Commun. 91:1979;395-401.
19. Crow D.S., Beyer E.C., Paul D.L., Kobe S.S., Lau A.F. Phosphorylation of connexin43 gap junction protein in uninfected and Rous sarcoma virus-transformed mammalian fibroblast. Mol. Cell. Biol. 10:1990;1754-1763.
20. Oh S.Y., Schmidt S.A., Murray A.W. Epidermal growth factor inhibits gap junctional communication and stimulates serine-phosphorylation of connexin 43 in WB cells by a protein kinase C-independent mechanism. Cell Adhes. Commun. 1:1993;143-149.
21. Musil L.S., Cunningham B.A., Edelman G.A., Goodenough D.A. Differential phosphorylation of the gap junction protein connexin43 in junctional communication-competent and -deficient cell lines. J. Cell Biol. 111:1990;2077-2088.
22. Matesic D.F., Rupp H.L., Bonney W.J., Ruch R.J., Trosko J.E. Changes in gap junction permeability, phosphorylation, and number mediated by phorbol ester and non-phorbol ester tumor promoters. Mol. Carcinogen. 10:1994;226-236.
23. El-Fouly M.H., Trosko J.E., Chang C.C., Warren S.T. Potential role of human Ha-ras oncogene in the inhibition of gap junctional intercellular communication. Mol. Carcinogen. 2:1989;131-135.
24. de Feijter A.W., Ray J.S., Weghorst C.M., Klaunig J.E., Goodman J.I., Chang C.C., Ruch R.J., Trosko J.E. Infection of rat liver epithelial cells with v-Ha-ras, correlation between oncogene expression, gap junctional communication, and tumorigenicity. Mol. Carcinogen. 3:1990;54-67.
25. de Feijter A.W., Trosko J.E., Krizman D.B., Lebovitz R.M., Lieberman M.W. Correlation of increased levels of Ha-ras T24 protein with extent of loss of gap junction function in rat liver epithelial cells. Mol. Carcinogen. 5:1992;205-212.
26. Ruch R.J., Madhukar B.V., Trosko J.E., Klaunig J.E. Reversal of ras-induced inhibition of gap junctional intercellular communication, transformation and tumorigenesis by lovastatin. Mol. Carcinogen. 7:1993;50-59.
27. Kalimi G.H., Hampton L.L., Trosko J.E., Thorgeirsson S.S., Huggett A.C. Homologous and heterologous gap junctional intercellular communication in v-raf-, v-myc- and v-raf/v-myc-transduced rat liver epithelial cell lines. Mol. Carcinogen. 5:1992;301-310.
28. Adams J.M., Cory S. Transgenic models of tumor development. Science. 254:1991;1161-1167.
29. Lotem J., Sachs L. Regulation by bcl-2, c-myc, and p53 of susceptibility to induction of apoptosis by heat shock and cancer chemotherapy compounds in differentiation-competent and -defective myeloid leukemic cells. Cell Growth Diff. 4:1993;41-47.
30. Askew D.S., Ashmun R.A., Simmons B.C., Cleveland J.L. Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis. Oncogene. 6:1991;1915-1922.
31. Lotem J., Sachs L. A mutant p53 antagonizes the deregulated c-myc-mediated enhancement of apoptosis and decrease in leukemogenicity. Proc. Natl. Acad. Sci. USA. 92:1995;9672-9676.
32. Arends M.J., McGregor A.H., Willie A.H. Apoptosis is inversely related to necrosis and determines net growth in tumors bearing constitutively expressed myc, ras and HPV oncogenes. Am. J. Pathol. 144:1994;1045-1057.
33. Fernandez-Sarabia M.J., Biscoff J.R. Bcl-2 associates with the ras related protein R-ras p23. Nature. 36:1993;274-277.
34. Sklar M.D. The ras oncogene increase the intrinsic resistance of NIH3T3 cells to ionizing radiation. Science. 239:1988;645-647.
35. Cleveland J.L., Troppmair J., Packham G., Askew D.S., Lloyd P., Gonzalez-Gracia M., Nunez G., Ihle J.N., Rapp U.R. V-raf suppresses apoptosis and promotes growth of interleukin-3-dependent myeloid cells. Oncogene. 9:1994;2217-2226.
36. Jou Y.S., Layhe B., Matesic D.F., Chang C.C., de Feijter A.W., Lockwood L., Welsch C.W., Klaunig J.E., Trosko J.E. Inhibition of gap junctional intercellular communication and malignant transformation of rat liver epithelial cells by neu oncogene. Carcinogenesis. 16:1995;311-317.
37. El-Fouly M.H., Trosko J.E., Chang C.C. Scrape-loading and dye transfer. A rapid and simple technique to study gap junctional intercellular communication. Exp. Cell Res. 168:1987;422-430.
38. Smith G.J., Bell W.N., Grisham J.W. Clonal analysis of the expression of multiple transformation phenotypes and tumorigenicity by morphologically transformed 10T1/2 cells. Cancer Res. 53:1993;500-508.
39. Wade M.H., Trosko J.E., Schindler M. A fluorescence photobleaching assay of gap junction mediated communication between human cells. Science. 232:1986;525-528.
40. Lüscher B., Eisenman R.N. New light on Myc and Myb. Part I. Myc. Genes Dev. 4:1990;2025-2035.
41. Worland P.J., Hampton L.L., Thorgeirsson S.S., Huggett A.C. Development of an in vitro model of tumor progression using v-raf and v-raf/v-myc transformed rat liver epithelial cells. Correlation of tumorigenicity with the downregulation of specific proteins. Mol. Carcinogen. 3:1990;20-29.
42. Hampton L.L., Worland P.J., Yu B., Thorgeirsson S.S., Huggett A.C. Association of the expression of growth related genes with tumorigenicity of v-raf transformed rat liver epithelial cells. Cancer Res. 50:1990;7468-7475.
43. Loewenstein W.R. Junctional intercellular communication and the control of growth. Biochim. Biophys. Acta. 560:1979;1-65.
44. Kanno Y. Modulation of cell communication and carcinogenesis. Jpn. J. Physiol. 35:1985;693-707.
45. Nicolson G.L., Dulski K.M., Trosko J.E. Loss of intercellular junctional communication correlates with metastatic potential in mammary adenocarcinoma cells. Proc. Natl. Acad. Sci. USA. 85:1988;473-476.
46. Yamasaki H., Naus C.C.G. Role of connexin genes in growth control. Carcinogenesis. 17:1996;1199-1213.
47. Weinstein I.B. The origins of human cancer, molecular mechanisms of carcinogenesis and their implications for cancer prevention and treatment. Cancer Res. 48:1988;4135-4143.
48. Weinberg R.A. Oncogenes, antioncogenes and the molecular bases of multistep carcinogenesis. Cancer Res. 49:1989;3713-3721.
49. Land H., Parada L.F., Weinberg R.A. Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes. Nature. 304:1983;596-602.
50. Scolnick E.M., Papageorge A.G., Shih T.Y. Guanine nucleotide-binding activity as an assay for src protein of rat-derived murine sarcoma viruses. Proc. Natl. Acad. Sci. USA. 76:1979;5355-5359.
51. Fleischman L.F., Chahwala S.B., Cantley L. Ras-transformed cells, altered levels of phosphatidyl inositol 4,5-bisphosphate and catabolites. Science. 231:1986;407-410.
52. Nishizuka Y. Studies and perspectives of protein kinase C. Science. 233:1986;305-312.
53. Demello W.C. Modulation of junctional permeability. Fed. Proc. 43:1984;2692-2696.
54. Leone G., DeGregorl J., Sears R., Jakoi L., Nevins J.R. Myc and ras collaborate in inducing cyclin E/Cdk2 and E2F. Nature. 387:1997;422-426.