Role of connexin (gap junction) genes in cell growth control and carcinogenesis

Comptes Rendus de l'Academie des Sciences - Serie III

Volumn 322, Issue 2-3, 1999, Pages 151-159

  Yamasaki, Hiroshi ^a   Krutovskikh, Vladimir ^a   Mesnil, Marc ^a   Tanaka, Toshiaki ^a   Zaidan Dagli, Maria Lucia ^a   Omori, Yasufumi ^a  

^a INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

Author keywords

Bystander effect; Cancer; Cell adhesion; Dominant negative mutations; Intercellular communication

Indexed keywords

CELL ADHESION MOLECULE; GANCICLOVIR; GAP JUNCTION PROTEIN;

CARCINOGEN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CANCER; CANCER CELL; CANCER CONTROL; CARCINOGENESIS; CATARACT; CELL COMMUNICATION; CELL GROWTH; CELL INTERACTION; CELL MUTANT; CONDUCTION DEAFNESS; CONGENITAL HEART MALFORMATION; CONTROLLED STUDY; GAP JUNCTION; GENE DELETION; GENE EXPRESSION; GENE MUTATION; GENE OVEREXPRESSION; GENE THERAPY; GENETIC TRANSFECTION; GROWTH REGULATION; HERPES SIMPLEX VIRUS; HUMAN; HUMAN TISSUE; LIVER REGENERATION; MOUSE; NONHUMAN; PARTIAL HEPATECTOMY; PROTEIN LOCALIZATION; RAT; TUMOR SUPPRESSOR GENE;

ANIMALIA; HERPES; MAMMALIA; MUS MUSCULUS; SIMPLEXVIRUS;

EID: 0033304080     PISSN: 07644469     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0764-4469(99)80038-9     Document Type: Article

References (65)

1. The cell-to-cell channel of gap junctions
2. Gap junctions
3. Connections with connexins; the molecular basis of direct intercellular signaling
4. The gap junction communication channel
5. Specific permeability and selective formation of gap junction channels in connexin-transfected HeLa cells
6. Differential properties of two gap junctional pathways made by All amacrine cells
7. The gap junction proteins beta(1)-connexin (connexin-32) and beta(2)connexin (connexin-26) can form heteromeric hemichannels
8. Cardiac malformation in neonatal mice lacking connexin 43
9. Female infertility in mice lacking connexin 37
10. Disruption of alpha3 connexin gene leads to proteolysis and cataractogenesis in mice
11. Defective propagation of signals generated by sympathetic nerve stimulation in the liver of connexin32-deficient mice
12. High incidence of spontaneous and chemically induced liver tumours in mice deficient for connexin32
13. Intercellular communication and the control of tissue growth: Lack of communication between cancer cells
14. Gap junctional intercellular communication and carcinogenesis
15. Ex-vivo dye transfer assay as an approach to study gap junctional intercellular communication disorders in hepatocarcinogenesis
16. Sequential changes of gap-junctional intercellular communications during multistage rat liver carcinogenesis: Direct measurement of communication in vivo
17. Selective lack of intercellular communication between transformed and non-transformed cells as a common property for chemical and oncogene transformation of BALB/c 3T3 cells
18. Selective gap junctional communication capacity of transformed and nontransformed rat-liver epithelial cell lines
19. Altered homologous and heterologous gap junctional intercellular communication in primary human liver tumours associated with aberrant protein localization but not gene mutation of connexin 32
20. The role of inhibited gap junction function in carcinogenesis
21. Cell culture assays for chemicals with tumour-promoting of tumour-inhibiting activity based on the modulation of intercellular communication
22. Performance of tests for cell transformation and gap-junction intercellular communication for detecting non-genotoxic carcinogenic activity
23. Elimination of metabolic cooperation in Chinese hamster cells by a tumour promoter
24. Tumour promoters inhibit metabolic cooperation in cocultures of epidermal and 3T3 cells
25. Role of disrupted gap junctional intercellular communication in detection and characterization of carcinogens
26. Differences in the expression of connexin genes in rat hepatomas in vivo and in vitro
27. Changes in gap junction protein (connexin 32) gene expression during rat liver carcinogenesis
28. Aberrant expression of gap junction gene in primary human hepatocellular carcinomas: Increased expression of cardiac-type gap junction gene connexin 43
29. Aberrant expression of gap junction proteins (connexins) is associated with tumour progression during multistage mouse skin carcinogenesis in vivo
30. Differential expression of the gap junction proteins connexin45, -43, -40, -31 and -26 in mouse skin
31. Hypermethylation of connexin32 gene as a mechanism of disruption of cell-cell communication in tumours
32. Alterations of (CA)(n) DNA repeats and tumour suppressor genes in human gastric cancer
33. Cx32 gene mutation in a chemically induced rat liver tumour
34. Connexin 37 mutations in rat hepatic angiosarcomas induced by vinyl chloride
35. Human connexin 37 is polymorphic but not mutated in tumours
36. Reduced expression of the P2 form of gap junction protein Cx43 in malignant meningiomas
37. Possible molecular mechanisms of loss of homologous and heterologous gap junctional intercellular communication in rat liver epithelial cell lines
38. ++ in mouse epidermal cells is controlled by E-cadherin
39. Adherens junction proteins in tumour progression
40. Suppression of tumorigenicity by plakoglobin: An augmenting effect of N-cadherin
41. Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies
42. Transfer of growth inhibition between normal and virus-transformed cells: Autoradiogrpahic studies using marked cells
43. Involvement of gap junctions in tumourigenesis: Transfection of cells with connexin32 cDNA retards growth in vivo
44. In vivo growth of C6 glioma cells transfected with connexin43 cDNA
45. Gap-junction protein gene suppresses tumorigenicity
46. Negative growth control of HeLa cells by connexin genes: Connexin species specificity
47. Connexin32 and X-linked Charcot-Marie Tooth disease, Cold Spring Harb
48. Immortalized connexin43 knock-out cell lines display a subset of biological properties associated with the transformed phenotype
49. Growth control of 3T3 fibroblast cell lines established from connexin 43-deficient mice
50. Connexin 32 mutations from X-linked Charcot-Marie Tooth disease patients; functional defects and dominant-negative effects
51. Null mutations of connexin 32 in patients with X-linked Charcot-Marie-Tooth disease
52. Identification of a proline residue as a transduction element involved in voltage gating of gap junctions
53. Dominant-negative abrogations of connexin-mediated cell growth control by mutant connexin genes
54. Inhibition of intrinsic gap junction intercellular communication and enhancement of tumorigenicity of rat bladder carcinoma BC31 cell line by dominant-negative Cx43 mutant
55. Dominant-negative inhibition of connexin-mediated tumour suppression by mutant connexin genes
56. Gap junctional intercellular communication and cell proliferation during rat liver carcinogenesis
57. α-fetoprotein and albumin mRNA levels in liver regeneration and carcinogenesis
58. In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumours
59. Novel method for selective killing of transformed rodent cells through intercellular communication with possible therapeutic applications
60. Bystander killing of cancer by HSV-tk gene is mediated by connexins
61. A tumour suppressor gene, Cx26, also mediates the bystander effect in HeLa cells
62. Long-term connexin-mediated bystander effect in highly tumorigenic human cells in vivo in herpes simplex virus thymidine kinase/ganciclovir gene therapy
63. Biological functions of gap junctions revealed by targeted inactivation of mouse connexin32-, -26 and -40 genes
64. Mice lacking connexin40 have cardiac conduction abnormalities characteristic of atrioventricular block and bundle branch block
65. Reduced cardiac conduction velocity and predisposition to arrhythmias in connexin40-deficient mice