Indian hedgehog (Ihh) both promotes and restricts thymocyte differentiation

Blood

Volumn 113, Issue 10, 2009, Pages 2217-2228

  Outram, Susan V ^a   Hager Theodorides, Ariadne L ^a   Shah, Divya K ^a   Rowbotham, Nicola J ^a   Drakopoulou, Ekati ^a   Ross, Susan E ^a   Lanske, Beate ^b   Dessens, Johannes T ^c   Crompton, Tessa ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b HARVARD SCHOOL OF DENTAL MEDICINE   (United States)

^c LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

SONIC HEDGEHOG PROTEIN; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL DIFFERENTIATION; CELL MATURATION; CELL POPULATION; CELL PROLIFERATION; CONTROLLED STUDY; EXPLANT; FETUS; GROWTH REGULATION; HETEROZYGOTE; HOMEOSTASIS; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; STEM CELL; T LYMPHOCYTE; THYMOCYTE; THYMUS; TISSUE LEVEL; WILD TYPE;

EID: 64049114135     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2008-03-144840     Document Type: Article

References (43)

1. DiSanto JP, Muller W, Guy-Grand D, Fischer A, Rajewsky K. Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain. Proc Natl Acad Sci USA. 1995;92:377-381.
2. Radtke F, Wilson A, Stark G, et al. Deficient T cell fate specification in mice with an induced inactivation of Notch1. Immunity. 1999;10:547-558.
3. Maillard I, Fang T, Pear WS. Regulation of lymphoid development, differentiation, and function by the Notch pathway. Annu Rev Immunol. 2005;23:945-974.
4. Staal FJ, Clevers HC. Wnt signaling in the thymus. Curr Opin Immunol. 2003;15:204-208.
5. Shah DK, Hager-Theodorides AL, Outram SV, Ross SE, Varas A, Crompton T. Reduced thymocyte development in sonic hedgehog knockout embryos. J Immunol. 2004;172:2296-2306.
6. Ingham PW, McMahon AP. Hedgehog signaling in animal development: paradigms and principles. Genes Dev. 2001;15:3059-3087.
7. Ingham PW, Placzek M. Orchestrating ontogenesis: variations on a theme by sonic hedgehog. Nat Rev Genet. 2006;7:841-850.
8. Varas A, Hernandez-Lopez C, Valencia J, et al. Survival and function of human thymic dendritic cells are dependent on autocrine Hedgehog signaling. J Leukoc Biol. 2008;83:1476-1483.
9. Uhmann A, Dittmann K, Nitzki F, et al. The Hedgehog receptor Patched controls lymphoid lineage commitment. Blood. 2007;110:1814-1823.
10. Outram SV, Varas A, Pepicelli CV, Crompton T. Hedgehog signaling regulates differentiation from double-negative to double-positive thymocyte. Immunity. 2000;13:187-197.
11. Bhardwaj G, Murdoch B, Wu D, et al. Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation. Nat Immunol. 2001;2:172-180.
12. Chiang C, Litingtung Y, Lee E, et al. Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature. 1996;383:407-413.
13. St-Jacques B, Hammerschmidt M, McMahon AP. Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation. Genes Dev. 1999;13:2072-2086.
14. Zhang XM, Ramalho-Santos M, McMahon AP. Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node. Cell. 2001;106:781-792.
15. Razzaque MS, Soegiarto DW, Chang D, Long F, Lanske B. Conditional deletion of Indian hedgehog from collagen type 2alpha1-expressing cells results in abnormal endochondral bone formation. J Pathol. 2005;207:453-461.
16. Ashe HL, Briscoe J. The interpretation of morphogen gradients. Development. 2006;133:385-394.
17. Borowski C, Martin C, Gounari F, et al. On the brink of becoming a T cell. Curr Opin Immunol.2002;14:200-206.
18. Petrie HT, Tourigny M, Burtrum DB, Livak F. Precursor thymocyte proliferation and differentiation are controlled by signals unrelated to the pre-TCR. J Immunol. 2000;165:3094-3098.
19. Crompton T, Outram SV, Hager-Theodorides AL. Sonic hedgehog signalling in T-cell development and activation. Nat Rev Immunol. 2007;7:726-735.
20. Sacedon R, Varas A, Hernandez-Lopez C, et al. Expression of hedgehog proteins in the human thymus. J Histochem Cytochem. 2003;51:1557-1566.
21. Andaloussi AE, Graves S, Meng F, Mandal M, Mashayekhi M, Aifantis I. Hedgehog signaling controls thymocyte progenitor homeostasis and differentiation in the thymus. Nat Immunol. 2006;7:418-426.
22. Rowbotham NJ, Hager-Theodorides AL, Cebecauer M, et al. Activation of the Hedgehog signaling pathway in T-lineage cells inhibits TCR repertoire selection in the thymus and peripheral T-cell activation. Blood. 2007;109:3757-3766.
23. - double-negative thymocytes. Blood. 2005;106:1296-1304.
24. Gutierrez-Frias C, Sacedon R, Hernandez-Lopez C, et al. Sonic hedgehog regulates early human thymocyte differentiation by counteracting the IL-7-induced development of CD34+ precursor cells. J Immunol. 2004;173:5046-5053.
25. Rowbotham NJ, Furmanski AL, Hager-Theodorides AL, et al. Repression of hedgehog signal transduction in T-lineage cells increases TCR-induced activation and proliferation. CellCycle. 2008;7:904-908.
26. Rowbotham NJ, Hager-Theodorides AL, Furmanski AL, Crompton T. Anovel role for Hedgehog in T-cell receptor signaling: implications for development and immunity. Cell Cycle.2007;6:2138-2142.
27. de Boer J, Williams A, Skavdis G, et al. Transgenic mice with hematopoietic and lymphoid specific expression of Cre. Eur J Immunol. 2003;33:314-325.
28. Hager-Theodorides AL, Rowbotham NJ, Outram SV, Dessens JT, Crompton T. Beta-selection: abundance of TCRbeta-/gammadelta-CD44-CD25-(DN4) cells in the foetal thymus. Eur J Immunol. 2007;37:487-500.
29. Gounari F, Chang R, Cowan J, et al. Loss of adenomatous polyposis coli gene function disrupts thymic development. Nat Immunol. 2005;6:800-809.
30. Bai CB, Auerbach W, Lee JS, Stephen D, Joyner AL. Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway. Development. 2002;129:4753-4761.
31. Hoffman ES, Passoni L, Crompton T, et al. Productive T-cell receptor beta-chain gene rearrangement: coincident regulation of cell cycle and clonality during development in vivo. Genes Dev. 1996;10:948-962.
32. Neumann CJ. Hedgehogs as negative regulators of the cell cycle. Cell Cycle. 2005;4:1139-1140.
33. van den Brink GR. Hedgehog signaling in development and homeostasis of the gastrointestinal tract. Physiol Rev. 2007;87:1343-1375.
34. Locker M, Agathocleous M, Amato MA, Parain K, Harris WA, Perron M. Hedgehog signaling and the retina: insights into the mechanisms controlling the proliferative properties of neural precursors. Genes Dev. 2006;20:3036-3048.
35. Masai I, Yamaguchi M, Tonou-Fujimori N, Komori A, Okamoto H. The hedgehog-PKA pathway regulates two distinct steps of the differentiation of retinal ganglion cells: the cell-cycle exit of reti-noblasts and their neuronal maturation. Development. 2005;132:1539-1553.
36. Agathocleous M, Locker M, Harris WA, Perron M. A general role of hedgehog in the regulation of proliferation. Cell Cycle. 2007;6:156-159.
37. Tenzen T, Allen BL, Cole F, Kang JS, Krauss RS,McMahon AP. The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathwayand feedback network in mice. Dev Cell. 2006;10:647-656.
38. Yoon JW, Kita Y, Frank DJ, et al. Gene expression profiling leads to identification of GLI1-binding elements in target genes and a role for multiple downstream pathways in GLI1-induced cell transformation. J Biol Chem. 2002;277:5548-5555.
39. ShkumatavaA, Neumann CJ. Shh directs cell-cycle exit by activating p57Kip2 in the zebrafish retina. EMBO Rep. 2005;6:563-569.
40. Varas A, Hager-Theodorides AL, Sacedon R, Vicente A, Zapata AG, Crompton T. The role of morphogens in T-cell development. Trends Immunol. 2003;24:197-206.
41. Cejalvo T, Sacedon R, Hernandez-Lopez C, et al. Bone morphogenetic protein-2/4 signalling pathway components are expressed in the human thymus and inhibit early T-cell development. Immunology. 2007;121:94-104.
42. Hager-Theodorides AL, Outram SV, Shah DK, et al. Bone morphogenetic protein 2/4 signaling regulates early thymocyte differentiation. J Immunol. 2002;169:5496-5504.
43. Graf D, Nethisinghe S, Palmer DB, Fisher AG, Merkenschlager M. The developmentally regulated expression of Twisted gastrulation reveals a role for bone morphogenetic proteins in the control of T cell development. J Exp Med. 2002;196:163-171.