Novel aminopeptidase N inhibitors derived from antineoplaston AS2-5 (Part II)

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 8, 2009, Pages 3061-3071

  Li, Xun ^a   Wang, Yazhou ^a   Wu, Jifeng ^b   Li, Yonggang ^a   Wang, Qiang ^a   Xu, Wenfang ^a  

^a SHANDONG UNIVERSITY   (China)

^b Ji'nan Public Security Bureau   (China)

Author keywords

Anti tumor; Antineoplaston AS2 5; APN inhibitors; Ferulic acid; l iso Glutamine derivatives; Peptidomimetics

Indexed keywords

2 (3 (3,4 DIMETHOXYPHENYL)ACRYLAMIDO) N 1,N 5 DIP TOLYLPENTANEDIAMIDE; 2 (3 (3,4 DIMETHOXYPHENYL)ACRYLAMIDO)PENTANEDIOIC ACID; 2 (3,4,5 TRIMETHOXYBENZAMIDO)PENTANEDIOIC ACID; 3 (3,4 DIMETHOXYPHENYL)ACRYLIC ACID; 3,4,5 TRIMETHOXYBENZOIC CHLORIDE; 4 (3 (3,4 DIMETHOXYPHENYL)ACRYLAMIDO) 5 (1 METHOXY 1 OXOPROPAN 2 YLAMINO) 5 OXOPENTANOIC ACID; 4 (3 (3,4 DIMETHOXYPHENYL)ACRYLAMIDO) 5 (1 METHOXY 3 METHYL 1 OXOBUTAN 2 YLAMINO) 5 OXOPENTANOIC ACID; 4 (3 (3,4 DIMETHOXYPHENYL)ACRYLAMIDO) 5 (2 FLUOROPHENYLAMINO) 5 OXOPENTANOIC ACID; 4 (3 (3,4 DIMETHOXYPHENYL)ACRYLAMIDO) 5 (2 METHOXY 2 OXOETHYLAMINO) 5 OXOPENTANOIC ACID; 4 (3 (3,4 DIMETHOXYPHENYL)ACRYLAMIDO) 5 (3 (4 FLUOROPHENYL) 1 METHOXY 1 OXOPROPAN 2 YLAMINO) 5 OXOPENTANOIC ACID; 4 (3 (3,4 DIMETHOXYPHENYL)ACRYLAMIDO) 5 (4 FLUOROPHENYLAMINO) 5 OXOPENTANOIC ACID; 4 (3 (3,4 DIMETHOXYPHENYL)ACRYLAMIDO) 5 (ETHYLAMINO) 5 OXOPENTANOIC ACID; 4 (3 (3,4 DIMETHOXYPHENYL)ACRYLAMIDO) 5 (ISOPROPYLAMINO) 5 OXOPENTANOIC ACID; 4 (3 (3,4 DIMETHOXYPHENYL)ACRYLAMIDO) 5 (METHYLAMINO) 5 OXOPENTANOIC ACID; 4 (3 (3,4 DIMETHOXYPHENYL)ACRYLAMIDO) 5 OXO 5 (PROPYLAMINO)PENTANOIC ACID; 5 (1,4 DIMETHOXY 1,4 DIOXOBUTAN 2 YLAMINO) 4 (3 (3,4 DIMETHOXYPHENYL)ACRYLAMIDO) 5 OXOPENTANOIC ACID; 5 (2 CHLOROPHENYLAMINO) 4 (3 (3,4 DIMETHOXYPHENYL)ACRYLAMIDO) 5 OXOPENTANOIC ACID; 5 (3 CHLOROPHENYLAMINO) 4 (3 (3,4 DIMETHOXYPHENYL)ACRYLAMIDO) 5 OXOPENTANOIC ACID; 5 (3,5 DIFLUOROPHENYLAMINO) 4 (3 (3,4 DIMETHOXYDIMETHOXYPHENYL)ACRYLAMIDO) 5 OXOPENTANOIC ACID; 5 (4 BROMOPHENYLAMINO) 4 (3 (3,4 DIMETHOXYDIMETHOXYPHENYL)ACRYLAMIDO) 5 OXOPENTANOIC ACID; 5 (4 CHLOROPHENYLAMINO) 4 (3 (3,4 DIMETHOXYDIMETHOXYPHENYL)ACRYLAMIDO) 5 OXOPENTANOIC ACID; 5 (4 TOLUIDINO) 4 (3 (3,4 DIMETHOXYPHENYL)ACRYLAMIDO) 5 OXOPENTANOIC ACID; 5 (BENZYLAMINO) 4 (3 (3,4 DIMETHOXYPHENYL)ACRYLAMIDO) 5 OXOPENTANOIC ACID; ANTINEOPLASTIC AGENT; ANTINEOPLASTON AS2 5; BESTATIN; FERULIC ACID; GELATINASE A; GLUTAMINE DERIVATIVE; MICROSOMAL AMINOPEPTIDASE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; DRUG BINDING; DRUG STRUCTURE; ENZYME INHIBITION; IN VITRO STUDY; STRUCTURE ACTIVITY RELATION;

ANTIGENS, CD13; ANTINEOPLASTIC AGENTS; BINDING SITES; GLUTAMINE; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; PHENYLACETATES; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 64049112591     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.03.017     Document Type: Article

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