Aminopeptidase N (APN/CD13) is selectively expressed in vascular endothelial cells and plays multiple roles in angiogenesis

Cancer Letters

Volumn 243, Issue 1, 2006, Pages 135-143

  Fukasawa, Kazuteru ^a   Fujii, Hideji ^a   Saitoh, Yurika ^b   Koizumi, Keiichi ^b   Aozuka, Yasushi ^b   Sekine, Keiko ^a   Yamada, Masatoshi ^a   Saiki, Ikuo ^b,c   Nishikawa, Kiyohiro ^a  

^a R and D Division   (Japan)

^b UNIVERSITY OF TOYAMA   (Japan)

^c UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Adhesion; Aminopeptidase N (APN CD13); Angiogenesis; Tube like structure; Vascular endothelial cells

Indexed keywords

CELL ADHESION MOLECULE; COLLAGEN TYPE 1; FIBRONECTIN; GELATINASE A; MATRIGEL; MICROSOMAL AMINOPEPTIDASE; SMALL INTERFERING RNA;

ANGIOGENESIS; ARTICLE; CELL MIGRATION; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; MORPHOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; TUMOR CELL LINE;

ANTIGENS, CD13; CAPILLARIES; CELL ADHESION; CELL LINE; CELL LINE, TUMOR; CELL MOVEMENT; CELLS, CULTURED; COLLAGEN; DRUG COMBINATIONS; ENDOTHELIAL CELLS; GENE EXPRESSION; HUMANS; LAMININ; NEOVASCULARIZATION, PHYSIOLOGIC; PROTEOGLYCANS; RNA INTERFERENCE; RNA, SMALL INTERFERING;

EID: 33749449024     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2005.11.051     Document Type: Article

References (31)

1. Carmelit P., and Jain R.K. Angiogenesis in cancer and other diseases. Circ. Res. 87 (2000) 176-178
2. Liotta L., Steeg P., and Stetler-Stevenson W. Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell 64 (1991) 327-336
3. Hanahan D., and Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86 (1996) 353-364
4. Folkman J. Fighting cancer by attacking its blood supply. Sci. Am. 275 (1996) 150-154
5. Boehm T., Folkman J., Browder T., and O'reilly M.S. Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance. Nature 390 (1997) 404-407
6. John A., and Tuszynski G. The role of matrix metalloproteinases in tumor angiogenesis and tumor metastasis. Pathol. Oncol. Res. 7 (2001) 14-23
7. Chambers A.F., and Matrisian L.M. Changing views of the role of matrix metalloproteinase in metastasis. J. Natl Cancer Inst. 89 (1997) 1260-1270
8. Sato Y. Role of aminopeptidase in angiogenesis. Biol. Pharm. Bull. 27 (2004) 772-776
9. Marchio S., Lahdenranta J., Schlingemann R.O., Valdembri D., Wesseling P., Arap M.A., et al. Aminopeptidase A is a functional target in angiogenesis blood vessels. Cancer Cell 5 (2004) 151-162
10. Miyashita H., Yamazaki T., Akada T., Niizeki O., Ogawa M., Nishikawa S., et al. A mouse orthologue of puromycin-insensitive leucyl-specific aminopeptidase is expressed in endothelial cells and plays an important role in angiogenesis. Blood 99 (2002) 3241-3249
11. Ingber D., Fujita T., Kishimoto S., Sudo K., Kanamaru T., Brem H., et al. Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth. Nature 348 (1990) 555-557
12. Yamamoto T., Sudo K., and Fujita T. Significant inhibition of endothelial cell growth in tumor vasculature by an angiogenesis inhibitor, TNP-470 (AGM-1470). Anticancer Res. 14 (1994) 1-3
13. Saiki I., Fujii H., Yoneda J., Abe F., Nakajima M., Tsuruo T., et al. Role of aminopeptidase N (CD13) in tumor-cell invasion and extracellular matrix degradation. Int. J. Cancer 54 (1993) 137-143
14. Fujii H., Nakajima M., Saiki I., Yoneda J., Azuma I., and Tsuruo T. Human melanoma invasion and metastasis enhancement by high expression of aminopeptidase N/CD13. Clin. Exp. Metastasis 13 (1995) 337-344
15. Aozuka Y., Koizumi K., Saitoh Y., Ueda Y., Sakurai H., and Saiki I. Anti-tumor angiogenesis effect of aminopeptidase inhibitor bestatin against B16-BL6 melanoma cells orthotopically implanted into syngeneic mice. Cancer Lett. 216 (2004) 35-42
16. Shapiro L.H., Ashmun R.A., Roberts W.M., and Look A.T. Separate promoters control transcription of the human aminopeptidase N gene in myeloid and intestinal epithelial cells. J. Biol. Chem. 266 (1991) 11999-12007
17. Sanderink G., Artur Y., and Siest G. Human aminopeptidases: a review of the literature. J. Clin. Chem. Clin. Biochem. 26 (1988) 795-807
18. Lendeckel U.A.M., Frank K., Wex T., and Ansorge S. Role of alanyl aminopeptidase in growth and function of human T cells. Int. J. Mol. Med. 4 (1999) 17-27
19. Bhagwat S.V., Lahdenranta J., Giordano R., Arap W., Pasqualini R., and Shapiro L.H. CD13/APN is activated by angiogenic signals and is essential for capillary tube formation. Blood 97 (2001) 652-659
20. Pasqualini R., Koivunen E., Kain R., Lahdenranra J., Sakamoto M., Stryhn A., et al. Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis. Cancer Res. 60 (2000) 722-727
21. Bhagwat S.V., Petrovic N., Okamoto Y., and Shapiro L.H. The angiogenic regulator CD13/APN is a transcriptional target of Ras signaling pathway in endothelial morphogenesis. Blood 101 (2003) 1818-1826
22. Petrovic N., Bhagwat S.V., Ratzan W.J., Ostrowski M.C., and Shapiro L.H. CD13/APN transcription is induced by RAS/MAPK-mediated phosphorylation of Ets-2 in activated endothelial cells. J. Cell Biol. 278 (2003) 49358-49368
23. Kido A., Krueger S., Haeckel C., and Roesssner A. Inhibitory effect of antisense aminopeptidase N (APN/CD13) cDNA transfection on the invasive potential of osteosarcoma cells. Clin. Exp. Metastasis 20 (2003) 585-592
24. Shim J., Kim J., Cho H., Yum Y., Kim S., Park H., et al. Irreversible inhibition of CD13/aminopeptidase N by the antiangiogenic agent curcumin. Chem. Biol. 10 (2003) 695-704
25. Shim J., Lee H., Shin J., and Kwon H. Psammaplin A, a marine natural product, inhibits aminopeptidase N and suppresses angiogenesis in vitro. Cancer Lett. 203 (2004) 163-169
26. Hashida H., Takabayashi A., Kanai M., Adachi M., Kondo K., Kohno N., et al. Aminopeptidase N is involved in cell motility and angiogenesis: its clinical significance in human colon cancer. Gastroenterology 122 (2002) 376-386
27. Liu L., Anderson W., Beart R., Gordon E., and Hall F. Incorporation of tumor vasculature targeting motifs into moloney murine leukemia virus env escort proteins enhances retrovirus binding and transduction of human endothelial cells. J. Virol. 74 (2000) 5320-5328
28. Koivunen E., Wang B., and Ruoslahti E. Isolation of a highly specific ligand for the alpha 5 beta 1 integrin from a phage display library. J. Cell Biol. 124 (1994) 373-380
29. Akada T., Yamazaki T., Miyashita H., Niizeki O., Abe M., Sato A., et al. Puromycin insensitive leucyl-specific aminopeptidase (PILSAP) is involved in the activation of endothelial integrins. J. Cell. Physiol. 193 (2002) 253-262
30. Bauvois B. A collagen-binding glycoprotein on the surface of mouse fibroblasts is identified as dipeptidyl peptidase IV. Biochem. J. 252 (1988) 723-731
31. Piazza G.A., Callanan H.M., Mowery J., and Hixson D.C. Evidence for a role of dipeptidyl peptidase IV in fibronectin-mediated interactions of hepatocytes with extracellular matrix. Biochem. J. 262 (1989) 327-334