First synthesis of α-aminoalkyl-(N-substituted)thiocarbamoyl-phosphinates: Inhibitors of aminopeptidase N (APN/CD13) with the new zinc-binding group

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 13, 2008, Pages 3734-3736

  Grzywa, Renata ^a   Oleksyszyn, Józef ^a  

^a WROCLAW UNIVERSITY OF TECHNOLOGY   (Poland)

Author keywords

Aminopeptidase N; APN inhibitors; Hydroxamic acid analogues; Phosphinate

Indexed keywords

MICROSOMAL AMINOPEPTIDASE; PHOSPHINIC ACID DERIVATIVE; ZINC BINDING PROTEIN;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROLYSIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RACEMIC MIXTURE;

ANTIGENS, CD13; BINDING SITES; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; HYDROXAMIC ACIDS; INHIBITORY CONCENTRATION 50; METALLOPROTEASES; MODELS, CHEMICAL; MOLECULAR STRUCTURE; PHOSPHINES; PHOSPHINIC ACIDS; STRUCTURE-ACTIVITY RELATIONSHIP; ZINC;

EID: 44849122246     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.05.050     Document Type: Article

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