Medium-chain fatty acids accumulating in MCAD deficiency elicit lipid and protein oxidative damage and decrease non-enzymatic antioxidant defenses in rat brain

Neurochemistry International

Volumn 54, Issue 8, 2009, Pages 519-525

  Schuck, Patrícia F ^a   Ferreira, Gustavo C ^a   Moura, Alana P ^a   Busanello, Estela N B ^a   Tonin, Anelise M ^a   Dutra Filho, Carlos S ^a   Wajner, Moacir ^a,b,c  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

^c UNIVERSIDADE LUTERANA DO BRASIL   (Brazil)

Author keywords

Decanoic acid; Lipid peroxidation; MCAD deficiency; Octanoic acid; Oxidative stress; Protein oxidation; Rat; Reactive oxygen species

Indexed keywords

ANTIOXIDANT; CARBONYL DERIVATIVE; CATALASE; DECANOIC ACID; GLUTATHIONE; MEDIUM CHAIN ACYL COENZYME A DEHYDROGENASE; MEDIUM CHAIN FATTY ACID; MELATONIN; N(G) NITROARGININE METHYL ESTER; NITRATE; NITRITE; OCTANOIC ACID; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; THIOL DERIVATIVE; TROLOX C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BIOACCUMULATION; BRAIN CORTEX; BRAIN HOMOGENATE; BRAIN MITOCHONDRION; CHEMOLUMINESCENCE; CONTROLLED STUDY; ENZYME DEFICIENCY; LIPID PEROXIDATION; MALE; MEDIUM CHAIN ACYL COENZYME A DEHYDROGENASE DEFICIENCY; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DETERMINATION; RAT; STATISTICAL ANALYSIS;

ACYL-COA DEHYDROGENASE; ANIMALS; ANTIOXIDANTS; BRAIN CHEMISTRY; CEREBRAL CORTEX; FATTY ACIDS; FREE RADICALS; GLUTATHIONE; LIPID METABOLISM; LIPID PEROXIDATION; LUMINESCENCE; MALE; NERVE TISSUE PROTEINS; NITRATES; NITRITES; OXIDATION-REDUCTION; OXIDATIVE STRESS; RATS; RATS, WISTAR; SULFHYDRYL COMPOUNDS; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

RATTUS;

EID: 64049107461     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2009.02.009     Document Type: Article

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