Toxoplasma gondii: Proteomic analysis of antigenicity of soluble tachyzoite antigen

Experimental Parasitology

Volumn 122, Issue 1, 2009, Pages 41-46

  Ma, Guang Yuan ^a,b   Zhang, Jian Zhong ^b   Yin, Guo Rong ^a   Zhang, Jian Hong ^a   Meng, Xiao Li ^a   Zhao, Fei ^b  

^a SHANXI MEDICAL UNIVERSITY   (China)

^b CHINESE CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

Author keywords

2 D electrophoresis (2 DE); Antigenicity; Mass spectrometry (MS); Proteomics; Soluble tachyzoite antigen (STAg); Toxoplasma gondii; Western blotting

Indexed keywords

ANTIGEN; ANTISERUM; GLUTAMATE DEHYDROGENASE; HEAT SHOCK PROTEIN 60; HEAT SHOCK PROTEIN 70; KHELLIN; MALATE DEHYDROGENASE; MEMBRANE ANTIGEN; PARASITE ANTIGEN; PEROXIREDOXIN; PROTEIN DISULFIDE ISOMERASE; PROTEIN KINASE C; PROTEIN KINASE C RECEPTOR 1; PROTOZOAL PROTEIN; PYRUVATE KINASE; SOLUBLE TACHYZOITE ANTIGEN; SURFACE ANTIGEN 1; TOXOPLASMA PROTEIN; UNCLASSIFIED DRUG; URIDINE PHOSPHORYLASE;

ANIMAL EXPERIMENT; ANTIGENICITY; ARTICLE; CONTROLLED STUDY; FEMALE; GENE MAPPING; GENETIC DATABASE; IMMUNITY; IMMUNOGENICITY; IMMUNOREGULATION; MALE; MASS SPECTROMETRY; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEOMICS; RABBIT; SWISS-PROT; TACHYZOITE; TOXOPLASMA GONDII; TWO DIMENSIONAL ELECTROPHORESIS; WESTERN BLOTTING;

ANIMALS; ANTIGENS, PROTOZOAN; BLOTTING, WESTERN; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ISOELECTRIC FOCUSING; MALE; MASS SPECTROMETRY; MICE; MICE, INBRED BALB C; PROTEOMICS; PROTOZOAN PROTEINS; PROTOZOAN VACCINES; RABBITS; TOXOPLASMA;

ANIMALIA; ORYCTOLAGUS CUNICULUS; TOXOPLASMA; TOXOPLASMA GONDII;

EID: 64049089589     PISSN: 00144894     EISSN: 10902449     Source Type: Journal    
DOI: 10.1016/j.exppara.2009.01.011     Document Type: Article

References (52)

1. Ahmed A.K., Mun H.S., Aosai F., Piao L.X., Fang H., Norose K., and Yano A. Roles of Toxoplasma gondii-derived heat shock protein 70 in host defense against T. gondii infection. Microbiology and Immunology 48 (2004) 911-915
2. Akerman S.E., and Müller S. Peroxiredoxin-linked detoxification of hydroperoxides in Toxoplasma gondii. The Journal of Biological Chemistry 280 (2005) 564-570
3. Ashour O.M., Naguib F.N., Goudgaon N.M., Schinazi R.F., and el Kouni M.H. Effect of administration of 5-(phenylselenenyl) acyclouridine, an inhibitor of uridine phosphorylase, on the anti-tumor efficacy of 5-fluoro-2′-deoxyuridine against murine colon tumor C26-10. Biochemical Pharmacology 60 (2000) 687-692
4. Bukau B., and Horwich A.L. The Hsp70 and Hsp60 chaperone machines. Cell 92 (1998) 351-366
5. Bülow R., and Boothroyd J.C. Protection of mice from fatal Toxoplasma gondii infection by immunization with p30 antigen in liposomes. Journal of Immunology 147 (1991) 3496-3500
6. Buxton D., and Innes E.A. A commercial vaccine for ovine toxoplasmosis. Parasitology 110 (1995) S11-S16
7. Charles E., Callegan M.C., and Blader I.J. The SAG1 Toxoplasma gondii surface protein is not required for acute ocular toxoplasmosis in mice. Infection and Immunity 75 (2007) 2079-2083
8. Cohen A.M., Rumpel K., Coombs G.H., and Wastling J.M. Characterisation of global protein expression by two-dimensional electrophoresis and mass spectrometry: proteomics of Toxoplasma gondii. International Journal for Parasitology 32 (2002) 39-51
9. Cook G.C. Toxoplasma gondii infection: a potential danger to the unborn fetus and AIDS sufferer. The Quarterly Journal of Medicine 74 (1990) 3-19
10. Coordinating Office of the National Survey on the Important Human Parasitic Diseases, 2005. A national survey on current status of the important parasitic diseases in human population. Chinese Journal of Parasitology and Parasitic Diseases 23, 332-340 [Chinese].
11. Cuppari A.F., Sanchez V., Ledesma B., Frank F.M., Goldman A., Angel S.O., and Martin V. Toxoplasma gondii protease inhibitor-1 (TgPI-1) is a novel vaccine candidate against toxoplasmosis. Vaccine 26 (2008) 5040-5045
12. de Hostos E.L., Bradtke B., Lottspeich F., Guggenheim R., and Gerisch G. Coronin, an actin binding protein of Dictyostelium discoideum localized to cell surface projections, has sequence similarities to G protein beta subunits. The EMBO Journal 10 (1991) 4097-4104
13. Deponte M., Rahlfs S., and Becker K. Peroxiredoxin systems of protozoal parasites. Sub-cellular Biochemistry 44 (2007) 219-229
14. Dobbin C.A., Smith N.C., and Johnson A.M. Heat shock protein 70 is a potential virulence factor in murine Toxoplasma infection via immunomodulation of host NF-kappa B and nitric oxide. Journal of Immunology 169 (2002) 958-965
15. el Kouni M.H., Naguib F.N., Panzica R.P., Otter B.A., Chu S.H., Gosselin G., Chu C.K., Schinazi R.F., Shealy Y.F., Goudgaon N., Ozerov A.A., Ueda T., and Iltzsch M.H. Effects of modifications in the pentose moiety and conformational changes on the binding of nucleoside ligands to uridine phosphorylase from Toxoplasma gondii. Biochemical Pharmacology 51 (1996) 1687-1700
16. Fleige T., Fischer K., Ferguson D.J., Gross U., and Bohne W. Carbohydrate metabolism in the Toxoplasma gondii apicoplast: localization of three glycolytic isoenzymes, the single pyruvate dehydrogenase complex, and a plastid phosphate translocator. Eukaryotic Cell 6 (2007) 984-996
17. Frand A.R., and Kaiser C.A. Two pairs of conserved cysteines are required for the oxidative activity of Ero1p in protein disulfide bond formation in the endoplasmic reticulum. Molecular Biology of the Cell 11 (2000) 2833-2843
18. Georgopoulos C., and Welch W.J. Role of the major heat shock proteins as molecular chaperones. Annual Review of Cell Biology 9 (1993) 601-634
19. Gerisch G., Albrecht R., Heizer C., Hodgkinson S., and Maniak M. Chemoattractant-controlled accumulation of coronin at the leading edge of Dictyostelium cells monitored using a green fluorescent protein-coronin fusion protein. Current Biology 5 (1995) 1280-1285
20. Golding G.B., and Dean A.M. The structural basis of molecular adaptation. Molecular Biology and Evolution 15 (1998) 355-369
21. Goward C.R., and Nicholls D.J. Malate dehydrogenase: a model for structure, evolution, and catalysis. Protein Science 3 (1994) 1883-1888
22. Havelaar A.H., Kemmeren J.M., and Kortbeek L.M. Disease burden of congenital toxoplasmosis. Clinical Infectious Diseases 44 (2007) 1467-1474
23. Hermanto U., Zong C.S., Li W., and Wang L.H. RACK1, an insulin-like growth factor I (IGF-I) receptor-interacting protein, modulates IGF-I-dependent integrin signaling and promotes cell spreading and contact with extracellular matrix. Molecular and Cellular Biology 22 (2002) 2345-2365
24. Igarashi M., Kano F., Tamekuni K., Machado R.Z., Navarro I.T., Vidotto O., Vidotto M.C., and Garcia J.L. Toxoplasma gondii: evaluation of an intranasal vaccine using recombinant proteins against brain cyst formation in BALB/c mice. Experimental Parasitology 118 (2008) 386-392
25. Iijima H., Takahashi I., and Kiyono H. Mucosal immune network in the gut for the control of infectious diseases. Reviews in Medical Virology 11 (2001) 117-133
26. Jewett T.J., and Sibley L.D. Aldolase forms a bridge between cell surface adhesins and the actin cytoskeleton in apicomplexan parasites. Molecular Cell 11 (2003) 885-894
27. Jungblut P.R., Zimny-Arndt U., Zeindl-Eberhart E., Stulik J., Koupilova K., Pleissner K.P., Otto A., Müller E.C., Sokolowska-Köhler W., Grabher G., and Stöffler G. Proteomics in human disease: cancer, heart and infectious diseases. Electrophoresis 20 (1999) 2100-2110
28. Kasper L., Courret N., Darche S., Luangsay S., Mennechet F., Minns L., Rachinel N., Ronet C., and Buzoni-Gatel D. Toxoplasma gondii and mucosal immunity. International Journal for Parasitology 34 (2004) 401-409
29. Lee E.G., Kim J.H., Shin Y.S., Shin G.W., Kim Y.R., Palaksha K.J., Kim D.Y., Yamane I., Kim Y.H., Kim G.S., Suh M.D., and Jung T.S. Application of proteomics for comparison of proteome of Neospora caninum and Toxoplasma gondii tachyzoites. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences 815 (2005) 305-314
30. Lourenço E.V., Pereira S.R., Faça V.M., Coelho-Castelo A.A., Mineo J.R., Roque-Barreira M.C., Greene L.J., and Panunto-Castelo A. Toxoplasma gondii micronemal protein MIC1 is a lactose-binding lectin. Glycobiology 11 (2001) 541-547
31. Maeda T., Saito T., Oguchi Y., Nakazawa M., Takeuchi T., and Asai T. Expression and characterization of recombinant pyruvate kinase from Toxoplasma gondii tachyzoites. Parasitology Research 89 (2003) 259-265
32. Meek B., Back J.W., Klaren V.N., Speijer D., and Peek R. Protein disulfide isomerase of Toxoplasma gondii is targeted by mucosal IgA antibodies in humans. FEBS Letters 522 (2002) 104-108
33. Meek B., Klaren V.N., van Haeringen N.J., Kijlstra A., and Peek R. IgA antibodies to Toxoplasma gondii in human tears. Investigative Ophthalmology & Visual Science 41 (2000) 2584-2590
34. Mohamed R.M., Aosai F., Chen M., Mun H.S., Norose K., Belal U.S., Piao L.X., and Yano A. Induction of protective immunity by DNA vaccination with Toxoplasma gondii HSP70, HSP30 and SAG1 genes. Vaccine 21 (2003) 2852-2861
35. Moran J.M., Smith S.S., and Hager K.M. Toxoplasma gondii possesses a receptor for activated C kinase ortholog. Biochemical and Biophysical Research Communications 363 3 (2007) 680-686
36. Mun H.S., Norose K., Aosai F., Chen M., and Yano A. A role of carboxy-terminal region of Toxoplasma gondii-heat shock protein 70 in enhancement of T. gondii infection in mice. The Korean Journal of Parasitology 38 (2000) 107-110
37. Mun H.S., Aosai F., Norose K., Chen M., Hata H., Tagawa Y.I., Iwakura Y., Byun D.S., and Yano A. Toxoplasma gondii Hsp70 as a danger signal in Toxoplasma gondii-infected mice. Cell Stress & Chaperones 5 (2000) 328-335
38. Musrati R.A., Kollárová M., Mernik N., and Mikulásová D. Malate dehydrogenase: distribution, function and properties. General Physiology and Biophysics 17 (1998) 193-210
39. Nam H.W., Im K.S., Baek E.J., Choi W.Y., and Cho S.Y. Analysis of antigenic domain of GST fused major surface protein (p30) fragments of Toxoplasma gondii. The Korean Journal of Parasitology 34 (1996) 135-141
40. Nischik N., Schade B., Dytnerska K., Długońska H., Reichmann G., and Fischer H.G. Attenuation of mouse-virulent Toxoplasma gondii parasites is associated with a decrease in interleukin-12-inducing tachyzoite activity and reduced expression of actin, catalase and excretory proteins. Microbes and Infection 3 (2001) 689-699
41. Ohashi K., Burkart V., Flohé S., and Kolb H. Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex. Journal of Immunology 164 (2000) 558-561
42. Pizzorno G., Yee L., Burtness B.A., Marsh J.C., Darnowski J.W., Chu M.Y., Chu S.H., Chu E., Leffert J.J., Handschumacher R.E., and Calabresi P. Phase I clinical and pharmacological studies of benzylacyclouridine, a uridine phosphorylase inhibitor. Clinical Cancer Research 4 (1998) 1165-1175
43. Remington J.S., McLeond R., and Desmonts G. Toxoplasmosis. In: Remington J.S., and Klein J.O. (Eds). Infectious diseases of the fetus and newborn infant (1995), W.B. Saunders Company, Philadelphia 140-267
44. Schaap D., Vermeulen A., Roberts C.W., and Alexander J. Vaccination against Toxoplasmosis: current status and future prospects. In: Kin, and Weiss (Eds). Toxoplasma gondii: the model apicomplexan-perspectives and methods (2007), Academic Press 721-760
45. Son E.S., Song K.J., Shin J.C., and Nam H.W. Molecular cloning and characterization of peroxiredoxin from Toxoplasma gondii. The Korean Journal of Parasitology 39 (2001) 133-141
46. Subauste C.S., and Remington J.S. Immunity to Toxoplasma gondii. Current Opinion in Immunology 5 (1993) 532-537
47. Tardieux I., Liu X., Poupel O., Parzy D., Dehoux P., and Langsley G. A Plasmodium falciparum novel gene encoding a coronin-like protein which associates with actin filaments. FEBS Letters 441 (1998) 251-256
48. Tenter A.M., Heckeroth A.R., and Weiss L.M. Toxoplasma gondii: from animals to humans. International Journal for Parasitology 30 (2000) 1217-1258
49. Uetrecht A.C., and Bear J.E. Coronins: the return of the crown. Trends in Cell Biology 16 (2006) 421-426
50. Wastling J.M. Proteomics of Toxoplasma gondii. In: Weiss L.M., and Kim K. (Eds). Toxoplasma gondii (2007), Academic Press, UK 550-551
51. Werner C., Stubbs M.T., Krauth-Siegel R.L., and Klebe G. The crystal structure of Plasmodium falciparum glutamate dehydrogenase, a putative target for novel antimalarial drugs. Journal of Molecular Biology 349 (2005) 597-607
52. Yin G.R., Meng X.L., Ma G.Y., and Ma X.M. Intranasal immunization with mucosal complex vaccine protects mice against Toxoplasma gondii. Chinese Journal of Parasitology and Parasitic Diseases 25 (2007) 290-294 [Chinese]