Roles of Toxoplasma gondii-derived heat shock protein 70 in host defense against T. gondii infection

Microbiology and Immunology

Volumn 48, Issue 11, 2004, Pages 911-915

  Ahmed, Azza Kamal ^a   Mun, Hye Seong ^a   Aosai, Fumie ^a   Piao, Lian Xun ^a   Fang, Hao ^a   Norose, Kazumi ^a   Yano, Akihiko ^a  

^a CHIBA UNIVERSITY   (Japan)

Author keywords

Immunosuppression; T.g.HSP70; Toxoplasma gondii

Indexed keywords

HEAT SHOCK PROTEIN 70;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DETERIORATION; DOSE RESPONSE; IMMUNE RESPONSE; NONHUMAN; PERITONEUM EXUDATE; PERITONEUM MACROPHAGE; PROTEIN ANALYSIS; PROTOZOAL INFECTION; SPLEEN; SURVIVAL; TH2 CELL; TOXOPLASMA GONDII; TOXOPLASMOSIS;

ANIMALIA; PROTOZOA; TOXOPLASMA GONDII;

EID: 10044288290     PISSN: 03855600     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1348-0421.2004.tb03611.x     Document Type: Article

References (27)

1. Adams, L.B., Hibbs, J.B., Jr., Taintor, R.R., and Krahenbuhl, J.L. 1990. Microbiostatic effect of murine-activated macrophages for Toxoplasma gondii. Role for synthesis of inorganic nitrogen oxides from L-arginine. J. Immunol. 144: 2725-2729.
2. Aosai, F., Chen, M., Kang, H.K., Mun, H.S., Norose, K., Piao, L.X., Kobayashi, M., Takeuchi, O., Akira, S., and Yano, A. 2002. Toxoplasma gondii-derived heat shock protein HSP70 functions as a B cell mitogen. Cell Stress Chaperones 7: 357-364.
3. Channon, J.Y., and Kasper, L.H. 1996. Toxoplasma gondii-induced immune suppression by human peripheral blood monocytes: role of gamma interferon. Infect. Immun. 64: 1181-1189.
4. Chen, M., Aosai, F., Mun, H.S., Norose, K., Hata, H., and Yano, A. 2000. Anti-HSP70 auto-antibody formation by B-1 cells in Toxoplasma gondii-infected mice. Infect. Immun. 68: 4893-4899.
5. Chen, M., Aosai, F., Norose, K., Mun, H.S., Takeuchi, O., Akira, S., and Yano, A. 2003. Involvement of MyD88 in host defense and the down-regulation of anti-HSP70 auto-antibody formation by MyD88 in Toxoplasma gondii-infected mice. J. Parasitol. 88: 1017-1019.
6. H1 B-1 cells in Toxoplasma gondii-infected mice. Int. Immunol. 15: 39-47.
7. Chen, M., Mun, H.S., Piao, L.X., Aosai, F., Norose, K., Mohamed, R.M., Belal, U.S., Fang, H., Ahmed, A.K., Kang, H.K., Matsuzaki, G., Kitamura, D., and Yano, A. 2003. Induction of protective immunity by primed B-1 cells in Toxoplasma gondii-infected B cell-deficient mice. Microbiol. Immunol. 47: 997-1003.
8. Fatoohi, A.F., Cozon, G.J., Gonzalo, P., Mayencon, M., Greenland, T., Picot, S., and Peyron, F. 2004. Heterogeneity in cellular and humoral immune responses against Toxoplasma gondii antigen in humans. Clin. Exp. Immunol. 136: 535-541.
9. Gavrilescu, L.C., Butcher, B.A., Rio, L.D., Taylor, G.A., and Denkers, E.Y. 2004. STAT1 is essential for antimicrobial effector function but dispensable for gamma interferon production during Toxoplasma gondii infection. Infect. Immun. 72: 1257-1264.
10. + T cells and accompanied by overproduction of IL-12, IFN-γ, and TNF-α. J. Immunol. 157: 798-805.
11. Kobayashi, M., Aosai, F., Hata, H., Mun, H.S., Tagawa, Y., Iwakura, Y., and Yano, A. 1999. Toxoplasma gondii: differences of invasion into tissue of digestive organs between susceptible and resistant strain and influence of IFN-γ in mice inoculated with the cyst perorally. J. Parasitol. 85: 973-975.
12. Kudo, M., Aosai, F., Mun, H.S., Norose, K., Akira, S., Iwakura, Y., and Yano, A. 2004. The role of IFN-γ and toll-like receptors in nephropathy induced by Toxoplasma gondii infection. Microbiol. Immunol. 48: 617-628.
13. Luo, W., Aosai, F., Ueda, M., Yamashita, K., Shimizu, K., Sekiya, S., and Yano, A. 1997. Kinetics in parasite abundance in susceptible and resistant mice infected with an avirulent strain of Toxoplasma gondii by using quantitative competitive PCR. J. Parasitol. 83: 1070-1074.
14. Mohamed, R., Aosai, F., Chen, M., Mun, H.S., Norose, K., Usama, S.B., Piao, L.X., and Yano, A. 2003. Induction of protective immunity by DNA vaccination with Toxoplasma gondii HSP70, HSP30 and SAG1 genes. Vaccine 21: 2852-2861.
15. Mun, H.S., Aosai, F., Chen, M., Piao, L.X., Norose, K., Iwakura, Y., and Yano, A. 2003. Pathogenicity of Toxoplasma gondii through B-2 cell mediated downregulation of host defense responses. Microbiol. Immunol. 47: 533-542.
16. Mun, H.S., Aosai, F., Norose, K., Chen, M., Hata, H., Tagawa, Y., Iwakura, Y., Byun, D.S., and Yano, A. 2000. Toxoplasma gondii Hsp70 as a danger signal in Toxoplasma gondii infected mice. Cell Stress Chaperones 54: 328-335.
17. Mun, H.S., Aosai, F., Norose, K., Chen, M., Piao, L.X., Takeuchi, O., Akira, S., Ishikura, H., and Yano, A. 2003. TLR2 as an essential molecule for protective immunity against Toxoplasma gondii infection. Int. Immunol. 15: 1081-1087.
18. Mun, H.S., Aosai, F., and Yano, A. 1999. Role of Toxoplasma gondii HSP70 and Toxoplasma gondii HSP30/bag1 in antibody formation and prophylactic immunity in mice experimentally infected with Toxoplasma gondii. Microbiol. Immunol. 43: 471-479.
19. Norose, K., Mun, H.S., Aosai, F., Chen, M., Hata, H., Tagawa, Y., Iwakura, Y., and Yano, A. 2001. Organ infectivity of Toxoplasma gondii in interferon-γ knockout mice. J. Parasitol. 87: 447-452.
20. Piao, L.X., Aosai, F., Chen, M., Fang, H., Mun, H.S., Norose, K., and Yano, A. 2004. A quantitative assay method of Toxoplasma gondii HSP70 mRNA by quantitative competitive-reverse transcriptase-PCR. Parasitol. Int. 53: 49-58.
21. Scharton-Kersten, T.M., Yap, G., Magram, J., and Sher, A. 1997. Inducible nitric oxide is essential for host control of persistent but not acute infection with the intracellular pathogen Toxoplasma gondii. J. Exp. Med. 185: 1261-1274.
22. Suzuki, Y., and Kobayashi, A. 1985. Macrophages-mediated suppression of immune responses in Toxoplasma-infected mice. II. Both H-2-linked and -nonlinked control of induction of suppressor macrophages. Cell. Immunol. 91: 375-384.
23. Swierczynski, B., Bessieres, M.H., Cassaing, S., Guy, S., Oswald, I., Seguela, J.P., and Pipy, B. 2000. Inhibitory activity of anti-interleukin-4 and anti-interleukin-10 antibodies on Toxoplasma gondii proliferation in mouse peritoneal macrophages cocultured with splenocytes from infected mice. Parasitol. Res. 86: 151-157.
24. Thouvenin, M., Candolfi, E., Villard, O., Klein, J.P., and Kien, T. 1997. Immune response in a murine model of congenital toxoplasmosis: increased susceptibility of pregnant mice and transplacental passage of Toxoplasma gondii are type 2-dependent. Parassitologia 39: 279-283.
25. Wei, S., Marches, F., Borvak, J., Zou, W., Channon, J., White, M., Radke, J., Cesbron-Delauw, M.F., and Curiel, T.J. 2002. Toxoplasma gondii-infected human myeloid dendritic cells induce T-lymphocyte dysfunction and contact-dependent apoptosis. Infect. Immun. 70: 1750-1760.
26. Yano, A., Mun, H.S., Chen, M., Norose, K., Hata, K., Kobayashi, M., and Aosai, F. 2002. Roles of IFN-γ on stage conversion of an obligate intracellular protozoan parasite, Toxoplasma gondii. Int. Rev. Immunol. 21: 405-421.
27. Yano, A., Norose, K., Kobayashi, Y., Aosai, F., Sugane, K., Segawa, K., and Hayashi, S. 1987. Immune response to Toxoplasma gondii-analysis of suppressor T cells in a patient with symptomatic acute toxoplasmosis. J. Parasitol. 73: 954-961.