Toxoplasma gondii: Evaluation of an intranasal vaccine using recombinant proteins against brain cyst formation in BALB/c mice

Experimental Parasitology

Volumn 118, Issue 3, 2008, Pages 386-392

  Igarashi, M ^a   Kano, F ^a   Tamekuni, K ^a   Machado, R Z ^b   Navarro, I T ^a   Vidotto, O ^a   Vidotto, M C ^a   Garcia, J L ^a  

^a STATE UNIVERSITY OF LONDRINA   (Brazil)

^b SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

Dense granule; Mouse; Recombinant proteins; Rhoptry; Toxoplasma gondii; Vaccine

Indexed keywords

CHOLERA TOXIN; IMMUNOGLOBULIN A; PHOSPHATE BUFFERED SALINE; RECOMBINANT PROTEIN;

ANIMAL EUTHANASIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY TITER; ARTICLE; BRAIN CYST; CONTROLLED STUDY; EXPERIMENTAL INFECTION; FEMALE; IMMUNOGLOBULIN BLOOD LEVEL; INFECTION PREVENTION; INFECTION RESISTANCE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROVOCATION TEST; TOXOPLASMA GONDII;

ADMINISTRATION, INTRANASAL; ANIMALS; ANTIGENS, PROTOZOAN; BLOTTING, WESTERN; BRAIN; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FEMALE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; PROTOZOAN PROTEINS; PROTOZOAN VACCINES; RECOMBINANT PROTEINS; SPECIFIC PATHOGEN-FREE ORGANISMS; TOXOPLASMA; TOXOPLASMOSIS, CEREBRAL; VACCINES, SYNTHETIC;

ANIMALIA; MUS; TOXOPLASMA GONDII;

EID: 38649091032     PISSN: 00144894     EISSN: 10902449     Source Type: Journal    
DOI: 10.1016/j.exppara.2007.10.002     Document Type: Article

References (39)

1. Achbarou A., Mercereau-Puijalon O., Sadak A., Fortier B., Leriche M.A., Camus D., and Dubremetz J.F. Differential targeting of dense granule proteins in the parasitophorous vacuole of Toxoplasma gondii. Parasitology 103 (1991) 321-329
2. Arrington J., Braun R.P., Dong L., Fuller D.H., Macklin M.D., Umlauf S.W., Wagner S.J., Wu M.S., Payne L.G., and Haynes J.R. Plasmid vectors encoding cholera toxin or the heat-labile enterotoxin from Escherichia coli are strong adjuvants for DNA vaccines. Journal of Virology 76 (2002) 4536-4546
3. Bonenfant C., Dimier-Poisson L., Velge-Roussel F., Buzoni-Gatel D., Rappuoli R., and Bout D. Intranasal immunization with SAG1 and nontoxic mutant heat-labile enterotoxins protects mice against Toxoplasma gondii. Infection and Immunity 69 (2001) 1605-1612
4. Bourguin I., Chardes T., and Bout D. Oral immunization with Toxoplasma gondii antigens in association with cholera toxin induces enhances protective and cell-mediated immunity in C57BL/6 mice. Infection and Immunity 61 (1993) 2082-2088
5. Brown C.R., Hunter C.A., Estes R.G., Beckmann E., Forman J., and David C. Definitive identification of gene that confers resistance against Toxoplasma cyst burden and encephalitis. Immunology 85 (1995) 419-428
6. 2+] and stimulate microneme discharge in Toxoplasma gondii. Biochemical Journal 342 (1999) 379-386
7. Cesbron-Delauw M.F. Dense granule organelles of Toxoplasma gondii: their role in the host-parasite relationship. Parasitology Today 10 (1994) 293-296
8. Charif H., Darcy F., Torpier G., Cesbron-Delauw M.F., and Capron A. Toxoplasma gondii: characterization and localization of antigens secreted from tachyzoites. Experimental Parasitology 71 (1990) 114-124
9. Debard N.D., Buzoni-Gatel D., and Bout D. Intranasal immunization with SAG1 protein of Toxoplasma gondii in association with cholera toxin dramatically reduces development of cerebral cysts after oral infection. Infection and Immunity 64 (1996) 2158-2166
10. Dubey J.P. Infectivity and pathogenicity of Toxoplasma gondii oocysts for cats. Journal of Parasitology 82 (1996) 957-961
11. Dubey J.P., and Frenkel J.K. Cyst-induced toxoplasmosis in cats. Journal of Protozoology 19 (1972) 155-177
12. Dubey J.P., Navarro I.T., Sreekumar C., Dahl E., Freire R.L., Kawabata H.H., Vianna M.C.B., Kwok O.C.H., Shen S.K., Thulliez P., and Lehmann T. Toxoplasma gondii infections in cats from Paraná, Brazil: Seroprevalence, tissue distribution, and biologic and genetic characterization of isolates. Journal of Parasitology 90 (2004) 721-726
13. Dubremetz J.F., and Schwartzman J.D. Subcellular organelles of Toxoplasma gondii and host cell invasion. Research Immunology 144 (1993) 31-33
14. Etzion Z., and Murray C.M. Isolation and characterization of rhoptries of Plasmodium falciparum. Molecular Biochemical Parasitology 47 (1991) 51-62
15. Ferguson D.J., Jacobs D., Saman E., Dubremetz J.F., and Wright S.E. In vivo expresion and distribution of dense granule protein 7 (GRA7) in exoenteric (tachyzoite, bradyzoite) and enteric (coccidian) forms of Toxoplasma gondii. Parasitology 119 (1999) 259-265
16. Fonjungo P.N., Stüber D., and McBride J.S. Antigenicity of recombinant proteins derived from rhoptry-associated protein 1 of Plasmodium falciparum. Infection and Immunity 66 (1998) 1037-1044
17. Frenkel J.K., Pfefferkorn E.R., Smith D.D., and Fishback J.L. Prospective vaccine prepared from a new mutant of Toxoplasma gondii for use in cats. American Journal Veterinary Research 52 (1991) 759-763
18. Frenkel J.K., and Smith D.D. Inhibitory effects of monesin on shedding of Toxoplasma oocysts by cats. Journal of Parasitology 68 (1982) 851-855
19. Garcia J.L., Navarro I.T., Ogawa L., and Kobilka F. Soroprevalência epidemiologia e avaliação ocular da toxoplasmose humana na área rural de Jaguapitã (Paraná), Brasil. Pan American Journal of Public Health 6 (1999) 157-163
20. Garcia J.L., Gennari S.M., Navarro I.T., Machado R.Z., Sinhorini I.L., Freire R.L., Marana E.R.M., Tsutsui V., Contente A.P.A., and Begale L.P. Partial protection against tissue cysts formation in pigs vaccinated with crude rhoptry proteins of Toxoplasma gondii. Veterinary Parasitology 129 (2005) 209-217
21. Jacobs D., Dubremetz J.F., Loyens A., Bosman F., and Saman E. Identification and heterologous expression of a new dense granule protein (GRA7) from Toxoplasma gondii. Molecular Biochemical Parasitology 91 (1998) 237-249
22. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227 (1970) 680-685
23. Lecordier L., Mercier C., Torpier G., Tourvieille B., Darcy F., Liu J.L., Maes P., Tartar A., Capron A., and Cesbron-Delauw M.F. Molecular structure of Toxoplasma gondii dense granule antigen (GRA5) associated with the parasitophorous vacuole membrane. Molecular Biochemical Parasitology 59 (1993) 143-153
24. Leriche M.A., and Dubremetz J.F. Exocytosis of Toxoplasma gondii dense granules into the parasitophorous vacuole after host cell invasion. Parasitology Research 76 (1990) 559-562
25. Leriche M.A., and Dubremetz J.F. Characterization of the protein contents of rhoptries and dense granules of Toxoplasma gondii tachyzoites by subcellular fractionation and monoclonal antibodies. Molecular Biochemical Parasitology 45 (1991) 249-260
26. Martin V., Supanitsky A., Echeverria P.C., Litwin S., Tanos T., De Roodt A.R., Guarnera E.A., and Angel S.O. Recombinant GRA4 or ROP2 protein combined with alum or the gra4 gene provides partial protection in chronic murine models of toxoplasmosis. Clinical Diagnostic Laboratory Immunology 11 (2004) 704-710
27. Metsis A., and Pettsersen E. Toxoplasma gondii: characterization of a monoclonal antibody recognizing antigens of 36 and 38 kDa with acid phosphatase activity located in dense granules and rhoptries. Experimental Parasitology 81 (1995) 472-479
28. Navarro I.T., Vidotto O., Giraldi N., and Freire R.L. Toxoplasma gondii: isolamento a partir de carne e cérebro de suínos comercializados na região de Londrina, Pr. Semina 13 (1992) 15-18
29. Ridley R.G., Takacs B., Lahm H.W., Delves C.J., Goman M., Certa U., Matile H., Woollet G.R., and Scaife J.G. Characterisation and sequence of a protective rhoptry antigen from Plasmodium falciparum. Molecular Biochimical Parasitology 41 (1990) 125-134
30. Saavedra R., De Meuter F., Decourt J.L., and Herion P. Human T-cell clone identifies a potencially protection 54-KDa protein antigen of Toxoplasma gondii cloned and expressed in Escherichia coli. Journal of Immunology 147 (1991) 1975-1982
31. Sabin A.B. Toxoplasmosis encephalites in children. Journal American Medical Association 16 (1941) 801-807
32. Saffer L.D., and Schwartzman J.D. A soluble phospholipase of Toxoplasma gondii associated with host cell penetration. Journal of Protozoology 38 (1991) 454-460
33. Stowers A., Prescott N., Cooper J., Takacs B., Stüber D., Kennedy P., and Saul A. Immunogenicity of recombinant Plasmodium falciparum rhoptry associated protein 1 and 2. Parasite Immunology 17 (1995) 631-642
34. Tilley M., Fichera M.E., Jerome M.E., Ross D.S., and White M.W. Toxoplasma gondii sporozoites form a transient parasitophorous vacuole that is impermeable and contains only a subset of dense-granule proteins. Infection and Immunity 65 (1997) 4598-4605
35. Towbin H., Staehelin T., and Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedures and some applications. Proceedings of the National Academic of Science 76 (1979) 4350-4354
36. Velge-Roussel F., Marcelo P., Lepage A.C., Buzoni-Gatel D., and Bout D.T. Intranasal immunization with Toxoplasma gondii SAG1 induces protective cells into both NALT and GALT compartments. Infection and Immunity 68 (2000) 969-972
37. Vercammen M., Scorza T., Huygen K., Braekeleer J., De Diet R., Jacobs D., Saman E., and Verschueren H. DNA vaccination with genes encoding Toxoplasma gondii antigens GRA1, GRA7, and ROP2 induces partially protective immunity against lethal challenge in mice. Infection and Immunity 68 (2000) 38-45
38. Winner L., Mack J., Weltzin R., Mekalanos J.J., Kraehenbuhl J.P., and Neutra M.R. New model for analysis of mucosal immunity: intestinal secretion of specific monoclonal immunoglobulin A from hybridoma tumors protect against Vibrio cholerae infection. Infection and Immunity 59 (1991) 977-982
39. Wu H.Y., and Russel M.W. Induction of a mucosal and systemic immune response by intranasal immunization using recombinant cholera toxin B subunit as adjuvant. Vaccine 16 (1998) 286-292