Retrograde viral transduction of cortical pyramidal neurons from the spinal cord

Restorative Neurology and Neuroscience

Volumn 26, Issue 6, 2008, Pages 509-520

  Groutsi, F ^a   Mason, M R J ^a,b   Anderson, P N ^b   Martins, S ^a   Anesti, M ^a   Coffin, R S ^a   Campbell, G ^a,b  

^a BioVex Ltd   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

corticospinal neurons; elongation factor 1 ; HSV1 vector; In vivo transduction; rat

Indexed keywords

2 HYDROXY 4,4' DIAMIDINOSTILBENE, METHANESULFONATE SALT; 2-HYDROXY-4,4'-DIAMIDINOSTILBENE, METHANESULFONATE SALT; BETA GALACTOSIDASE; EPHRIN A2; GREEN FLUORESCENT PROTEIN; STILBAMIDINE;

ANIMAL; ARTICLE; BRAIN CORTEX; CELL COUNT; CYTOLOGY; FEMALE; GENE EXPRESSION; GENETIC TRANSDUCTION; GENETICS; HERPES SIMPLEX VIRUS 1; LEWIS RAT; MALE; METABOLISM; METHODOLOGY; PHYSIOLOGY; PYRAMIDAL NERVE CELL; PYRAMIDAL TRACT; RAT; SPINAL CORD;

ANIMALS; BETA-GALACTOSIDASE; CELL COUNT; CEREBRAL CORTEX; EPHRIN-A2; FEMALE; GENE EXPRESSION; GREEN FLUORESCENT PROTEINS; HERPESVIRUS 1, HUMAN; MALE; PYRAMIDAL CELLS; PYRAMIDAL TRACTS; RATS; RATS, INBRED LEW; SPINAL CORD; STILBAMIDINES; TRANSDUCTION, GENETIC;

EID: 64049088079     PISSN: 09226028     EISSN: 18783627     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Ace, C. I., McKee, T. A., Ryan, J. M., Cameron, J. M., Preston, C. M. (1989). Construction and characterization of a herpes simplex virus type 1 mutant unable to transinduce immediateearly gene expression. J Virol, 63, 2260-2269.
2. Bradbury, E. J., Moon, L. D., Popat, R. J., King, V. R., Bennett, G. S., Patel, P. N. et al. (2002). Chondroitinase ABC promotes functional recovery after spinal cord injury. Nature, 416, 636- 640.
3. Brown, S. M., Ritchie, D. A., Subak-Sharpe, J. H. (1973). Genetic studies with herpes simplex virus type 1. The isolation of temperature-sensitive mutants, their arrangement into complementation groups and recombination analysis leading to a linkage map. J Gen Virol, 18, 329-346.
4. Burger, C., Gorbatyuk, O. S., Velardo, M. J., Peden, C. S.,Williams, P., Zolotukhin, S. et al. (2004). Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous system. Mol Ther, 10, 302-317.
5. Chiocca, E. A., Choi, B. B., Cai, W. Z., DeLuca, N. A., Schaffer, P. A., DiFiglia, M. et al. (1990). Transfer and expression of the lacZ gene in rat brain neurons mediated by herpes simplex virus mutants. New Biol, 2, 739-746.
6. DeLuca, N. A., Courtney, M. A., Schaffer, P. A. (1984). Temperature-sensitive mutants in herpes simplex virus type 1 ICP4 permissive for early gene expression. J Virol, 52, 767- 776.
7. Donello, J. E., Loeb, J. E., Hope, T. J. (1998). Woodchuck hepatitis virus contains a tripartite posttranscriptional regulatory element. J Virol, 72, 5085-5092.
8. Dowd, E., Monville, C., Torres, E. M., Wong, L. F., Azzouz, M., Mazarakis, N. D. et al. (2005). Lentivector-mediated delivery of GDNF protects complex motor functions relevant to human Parkinsonism in a rat lesion model. European Journal of Neuroscience, 22, 2587-2595.
9. Glover, C. P., Bienemann, A. S., Hopton, M., Harding, T. C., Kew, J. N., Uney, J. B. (2003). Long-term transgene expression can be mediated in the brain by adenoviral vectors when powerful neuron-specific promoters are used. J Gene Med, 5, 554-559.
10. Hermens, W. T., Giger, R. J., Holtmaat, A. J., Dijkhuizen, P. A., Houweling, D. A., Verhaagen, J. (1997). Transient gene transfer to neurons and glia: analysis of adenoviral vector performance in the CNS and PNS. Journal of Neuroscience Methods, 71, 85-98.
11. Hlavaty, J., Schittmayer, M., Stracke, A., Jandl, G., Knapp, E., Felber, B. K. et al. (2005). Effect of posttranscriptional regulatory elements on transgene expression and virus production in the context of retrovirus vectors. Virology, 341, 1-11.
12. Howard, M. K., Coffin, R. S., Maclean, A. R., Brown, S. M., Bailey, D., Anderson, P. N. et al. (1997). Gene delivery to rat enteric neurons using herpes simplex virus- based vectors. Journal of Molecular Neuroscience, 9, 65-74.
13. Huang, F., Chotiner, J. K., Steward, O. (2005). The mRNA for elongation factor 1alpha is localized in dendrites and translated in response to treatments that induce long-term depression. Journal of Neuroscience, 25, 7199-7209.
14. Johnson, P. A., Friedmann, T. (1994). Replication-defective recombinant herpes simplex virus vectors. Methods Cell Biol, 43 Pt A, 211-230.
15. Kaspar, B. K., Llado, J., Sherkat, N., Rothstein, J. D., Gage, F. H. (2003). Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model. Science, 301, 839-842.
16. Kim, D. W., Uetsuki, T., Kaziro, Y., Yamaguchi, N., Sugano, S. (1990). Use of the human elongation factor 1 alpha promoter as a versatile and efficient expression system. Gene, 91, 217- 223.
17. Klein, R. L., Hamby,M. E., Gong, Y., Hirko, A. C.,Wang, S., Hughes, J. A. et al. (2002). Dose and promoter effects of adenoassociated viral vector for green fluorescent protein expression in the rat brain. Experimental Neurology, 176, 66-74.
18. Leaver, S. G., Cui, Q., Bernard, O., Harvey, A. R. (2006). Cooperative effects of bcl-2 and AAV-mediated expression of CNTF on retinal ganglion cell survival and axonal regeneration in adult transgenic mice. European Journal of Neuroscience, 24, 3323-3332.
19. Li, S., Liu, B. P., Budel, S., Li, M., Ji, B., Walus, L. et al. (2004). Blockade of Nogo-66, myelin-associated glycoprotein, and oligodendrocyte myelin glycoprotein by soluble Nogo-66 receptor promotes axonal sprouting and recovery after spinal injury. Journal of Neuroscience, 24, 10511-10520.
20. Lilley, C. E., Groutsi, F., Han, Z., Palmer, J. A., Anderson, P. N., Latchman, D. S. et al. (2001). Multiple immediate-early genedeficient herpes simplex virus vectors allowing efficient gene delivery to neurons in culture and widespread gene delivery to the central nervous system in vivo. J Virol, 75, 4343-4356.
21. Loeb, J. E., Cordier, W. S., Harris, M. E.,Weitzman, M. D., Hope, T. J. (1999). Enhanced expression of transgenes from adenoassociated virus vectors with the woodchuck hepatitis virus posttranscriptional regulatory element: implications for gene therapy. Hum Gene Ther, 10, 2295-2305.
22. Maclean, A. R., ul-Fareed, M., Robertson, L., Harland, J., Brown, S. M. (1991). Herpes simplex virus type 1 deletion variants 1714 and 1716 pinpoint neurovirulence-related sequences in Glasgow strain 17+ between immediate early gene 1 and the 'a' sequence. J Gen Virol, 72(3), 631-639.
23. Mason, M. R., Lieberman, A. R., Anderson, P. N. (2003). Corticospinal neurons up-regulate a range of growth-associated genes following intracortical, but not spinal, axotomy. European Journal of Neuroscience, 18, 789-802.
24. Mizushima, S., Nagata, S. (1990). pEF-BOS, a powerful mammalian expression vector. Nucleic Acids Research, 18, 5322.
25. Palmer, J. A., Branston, R. H., Lilley, C. E., Robinson, M. J., Groutsi, F., Smith, J. et al. (2000). Development and optimization of herpes simplex virus vectors for multiple long-term gene delivery to the peripheral nervous system. J Virol, 74, 5604- 5618.
26. Paterna, J. C., Moccetti, T., Mura, A., Feldon, J., Bueler, H. (2000). Influence of promoter and WHV post-transcriptional regulatory element on AAV-mediated transgene expression in the rat brain. Gene Ther, 7, 1304-1311.
27. Qiu, J., Whalen, M. J., Lowenstein, P., Fiskum, G., Fahy, B., Darwish, R. et al. (2002). Upregulation of the Fas receptor deathinducing signaling complex after traumatic brain injury in mice and humans. Journal of Neuroscience, 22, 3504-3511.
28. Sandler, V. M., Wang, S., Angelo, K., Lo, H. G., Breakefield, X. O., Clapham, D. E. (2002). Modified herpes simplex virus delivery of enhanced GFP into the central nervous system. Journal of Neuroscience Methods, 121, 211-219.
29. Sapieha, P. S., Peltier, M., Rendahl, K. G., Manning, W. C., Di, P. A. (2003). Fibroblast growth factor-2 gene delivery stimulates axon growth by adult retinal ganglion cells after acute optic nerve injury. Mol Cell Neurosci, 24, 656-672.
30. Schnell, L., Schwab, M. E. (1990). Axonal regeneration in the rat spinal cord produced by an antibody against myelin-associated neurite growth inhibitors. Nature, 343, 269-272.
31. Soudais, C., Laplace-Builhe, C., Kissa, K., Kremer, E. J. (2001). Preferential transduction of neurons by canine adenovirus vectors and their efficient retrograde transport in vivo. FASEB J, 15, 2283-2285.
32. Tamamaki, N., Nakamura, K., Furuta, T., Asamoto, K., Kaneko, T. (2000). Neurons in Golgi-stain-like images revealed by GFP-adenovirus infection in vivo. Neuroscience Research, 38, 231-236.
33. Thomas, S. K., Lilley, C. E., Latchman, D. S., Coffin, R. S. (1999). Equine herpesvirus 1 gene 12 can substitute for vmw65 in the growth of herpes simplex virus (HSV) type 1, allowing the generation of optimized cell lines for the propagation of HSV vectors with multiple immediate- early gene defects. J Virol, 73, 7399-7409.
34. Tracey, D. J. (1995). Ascending and descending pathways in the spinal cord. In G.Paxinos (Ed.), The rat nervous system (2 ed., pp. 67-80). San Diego: Academic Press.
35. van den Pol, A. N., Mocarski, E., Saederup, N., Vieira, J.,&Meier, T. J. (1999). Cytomegalovirus cell tropism, replication, and gene transfer in brain. Journal of Neuroscience, 19, 10948-10965.
36. Wickersham, I. R., Finke, S., Conzelmann, K. K., Callaway, E. M. (2007). Retrograde neuronal tracing with a deletion-mutant rabies virus. Nat Methods, 4, 47-49.
37. Wong, L. F., Azzouz, M., Walmsley, L. E., Askham, Z., Wilkes, F. J., Mitrophanous, K. A. et al. (2004). Transduction patterns of pseudotyped lentiviral vectors in the nervous system. Mol Ther, 9, 101-111.
38. Yip, P. K., Wong, L. F., Pattinson, D., Battaglia, A., Grist, J., Bradbury, E. J. et al. (2006). Lentiviral vector expressing retinoic acid receptor beta2 promotes recovery of function after corticospinal tract injury in the adult rat spinal cord. Hum Mol Genet, 15, 3107-3118.
39. Zufferey, R., Donello, J. E., Trono, D., Hope, T. J. (1999). Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors. J Virol, 73, 2886-2892.