메뉴 건너뛰기




Volumn 15, Issue 5, 1996, Pages 569-576

Distribution and metabolism of intravitreal cidofovir and cyclic HPMPC in rabbits

Author keywords

Cidofovir; Cyclic 1 (S) 3 hydroxy 2(phosphonomethoxy)propyl cytosine (HPMPC); Distribution; Intravitreal; Rabbit

Indexed keywords

ANTIVIRUS AGENT; CARBON 14; CIDOFOVIR; RADIOPHARMACEUTICAL AGENT;

EID: 0029977522     PISSN: 02713683     EISSN: None     Source Type: Journal    
DOI: 10.3109/02713689609000768     Document Type: Article
Times cited : (26)

References (21)
  • 1
    • 0025946562 scopus 로고
    • The causes of death in patients with human immunodeficiency virus infection: A clinical and pathologic study with emphasis on the role of pulmonary disease
    • McKenzie, R., Travis, W. D., Dolan, S. A., Pittaluga, S., Feuerstein, I. M., Shelhamer, J., Yarchoan, R. and Masur, H. (1991) The causes of death in patients with human immunodeficiency virus infection: a clinical and pathologic study with emphasis on the role of pulmonary disease. Medicine, 70, 326-343.
    • (1991) Medicine , vol.70 , pp. 326-343
    • McKenzie, R.1    Travis, W.D.2    Dolan, S.A.3    Pittaluga, S.4    Feuerstein, I.M.5    Shelhamer, J.6    Yarchoan, R.7    Masur, H.8
  • 2
    • 11944275015 scopus 로고
    • Mortality in patients with the acquired immunodeficiency syndrome treated with either foscarnet or ganciclovir for cytomegalovirus retinitis
    • AIDS Ophthalmology Study Group. Studies of Ocular Complications of AIDS Research Group. (1992) Mortality in patients with the acquired immunodeficiency syndrome treated with either foscarnet or ganciclovir for cytomegalovirus retinitis. N. Engl. J. Med. 326, 213-220.
    • (1992) N. Engl. J. Med. , vol.326 , pp. 213-220
  • 3
    • 0024541864 scopus 로고
    • Treatment of cytomegalovirus retinitis with intravitreal ganciclovir; long term results
    • Cantrill, H. L., Henry, K., Melroe, N. H., Knobloch, W. H., Ramsay, R. C. and Balfour, H. H. (1989) Treatment of cytomegalovirus retinitis with intravitreal ganciclovir; long term results. Ophthalmology, 96, 367-374.
    • (1989) Ophthalmology , vol.96 , pp. 367-374
    • Cantrill, H.L.1    Henry, K.2    Melroe, N.H.3    Knobloch, W.H.4    Ramsay, R.C.5    Balfour, H.H.6
  • 4
    • 85035161557 scopus 로고
    • The effect of ocular pigmentation in the vitreous disposition and elimination of acycloguanosine analogs
    • Abstract
    • Krishnamoorthy, R., Hughes, P. M. and Mitra, A. K. (1994) The effect of ocular pigmentation in the vitreous disposition and elimination of acycloguanosine analogs. (Abstract). Pharm. Res. 11 (Suppl.), S424.
    • (1994) Pharm. Res. , vol.11 , Issue.SUPPL.
    • Krishnamoorthy, R.1    Hughes, P.M.2    Mitra, A.K.3
  • 6
    • 0026537658 scopus 로고
    • Intracellular metabolism of the antiherpes agent (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine
    • Ho, H-T., Woods, K. L., Bronson, J. J., De Boeck, H., Martin, J. C. and Hitchcock, M. J. M. (1991) Intracellular metabolism of the antiherpes agent (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine. Molec. Pharmacol. 41, 197-202.
    • (1991) Molec. Pharmacol. , vol.41 , pp. 197-202
    • Ho, H.-T.1    Woods, K.L.2    Bronson, J.J.3    De Boeck, H.4    Martin, J.C.5    Hitchcock, M.J.M.6
  • 11
    • 0028958136 scopus 로고
    • A phase I/II study of intravitreal cidofovir (HPMPC) for the treatment of cytomegalovirus retinitis in patients with the acquired immune deficiency syndrome
    • Kirsch, L. S., Arevalo, J. F., De Clercq, E., de la Paz, E. C., Munguia, D., Garcia, R. and Freeman, W. R. (1995) A phase I/II study of intravitreal cidofovir (HPMPC) for the treatment of cytomegalovirus retinitis in patients with the acquired immune deficiency syndrome. Am. J. Ophthalmol. 119, 466-476.
    • (1995) Am. J. Ophthalmol. , vol.119 , pp. 466-476
    • Kirsch, L.S.1    Arevalo, J.F.2    De Clercq, E.3    De La Paz, E.C.4    Munguia, D.5    Garcia, R.6    Freeman, W.R.7
  • 12
    • 0028902311 scopus 로고
    • Intravitreal cidofovir (HPMPC) treatment of cytomegalovirus retinitis in patients with acquired immune deficiency syndrome
    • Kirsch, L. S., Arevalo, J. F., de la Paz, E. C., Munguia, D., De Clercq, E. and Freeman, W. R. (1995) Intravitreal cidofovir (HPMPC) treatment of cytomegalovirus retinitis in patients with acquired immune deficiency syndrome. Ophthalmology, 102, 533-542.
    • (1995) Ophthalmology , vol.102 , pp. 533-542
    • Kirsch, L.S.1    Arevalo, J.F.2    De La Paz, E.C.3    Munguia, D.4    De Clercq, E.5    Freeman, W.R.6
  • 14
    • 0000055156 scopus 로고
    • The cyclic congener of cidofovir has reduced nephrotoxicity in three species
    • Abstract
    • Hitchcock, M. J. M., Lacy, S. A., Lindsay, J. R. and Kern, E. (1995) The cyclic congener of cidofovir has reduced nephrotoxicity in three species. (Abstract). Antiviral Res. 26, A358.
    • (1995) Antiviral Res , vol.26
    • Hitchcock, M.J.M.1    Lacy, S.A.2    Lindsay, J.R.3    Kern, E.4
  • 15
    • 0001153009 scopus 로고
    • Synthesis of 9-(2-phosphonyl-methoxyethyl)adenine and related compounds
    • Holy, A. and Rosenberg, I. (1987) Synthesis of 9-(2-phosphonyl-methoxyethyl)adenine and related compounds. Collect. Czech. Chem. Commun. 52, 2801-2806.
    • (1987) Collect. Czech. Chem. Commun. , vol.52 , pp. 2801-2806
    • Holy, A.1    Rosenberg, I.2
  • 16
    • 0001003712 scopus 로고
    • Metabolism of 1-(s)-(3-hydroxy-2-phosphonomethoxypropyl)-cytosine (HPMPC) in human embryonic lung cells
    • Cihlar, T., Votruba, I., Horska, K., Liboska, R., Rosenberg, I. and Holy, A. (1992) Metabolism of 1-(s)-(3-hydroxy-2-phosphonomethoxypropyl)-cytosine (HPMPC) in human embryonic lung cells. Collect. Czech. Chem. Commun. 57, 661-672.
    • (1992) Collect. Czech. Chem. Commun. , vol.57 , pp. 661-672
    • Cihlar, T.1    Votruba, I.2    Horska, K.3    Liboska, R.4    Rosenberg, I.5    Holy, A.6
  • 17
    • 0009484623 scopus 로고
    • Tissue distribution and bioavailability of cyclic HPMPC, an intracellular prodrug of HPMPC. (Abstract)
    • Lee, W. A., Shaw, J-P., Bidgood, A. M., Lynch, G., Eisenberg, E. and Cundy, K. C. (1995) Tissue distribution and bioavailability of cyclic HPMPC, an intracellular prodrug of HPMPC. (Abstract). Antiviral Res. 26, A340.
    • (1995) Antiviral Res. , vol.26
    • Lee, W.A.1    Shaw, J.P.2    Bidgood, A.M.3    Lynch, G.4    Eisenberg, E.5    Cundy, K.C.6
  • 18
    • 0019945650 scopus 로고
    • The effects of infection and probenecid on the transport of carbenecillin from the rabbit vitreous humor
    • Barza, M., Kane, A. and Baum, J. (1982) The effects of infection and probenecid on the transport of carbenecillin from the rabbit vitreous humor. Invest. Ophthalmol. Vis. Sci. 22, 720-726.
    • (1982) Invest. Ophthalmol. Vis. Sci. , vol.22 , pp. 720-726
    • Barza, M.1    Kane, A.2    Baum, J.3
  • 19
    • 0022370634 scopus 로고
    • Amphotericin clearance in vitrectomized versus nonvitrectomized eyes
    • Doft, B. H., Weiskopf, J., Nilsson-Ehle, I. and Wingard Jr, I. (1985) Amphotericin clearance in vitrectomized versus nonvitrectomized eyes. Ophthalmology, 92, 1601-1605.
    • (1985) Ophthalmology , vol.92 , pp. 1601-1605
    • Doft, B.H.1    Weiskopf, J.2    Nilsson-Ehle, I.3    Wingard Jr., I.4
  • 20
    • 4243477645 scopus 로고
    • Metabolism and pharmacokinetic analysis of a phosphorothioate oligonucleotide after intravitreal injection
    • Abstract
    • Leeds, J. M., Kornbrust, D., Truong, L. and Henry, S. (1994) Metabolism and pharmacokinetic analysis of a phosphorothioate oligonucleotide after intravitreal injection. (Abstract). Pharm. Res. 11 (Suppl.), S353.
    • (1994) Pharm. Res. , vol.11 , Issue.SUPPL.
    • Leeds, J.M.1    Kornbrust, D.2    Truong, L.3    Henry, S.4
  • 21
    • 0038023667 scopus 로고
    • Effect of concomitant probenecid on the tissue distribution and urinary excretion of HPMPC in preclinical models
    • Abstract
    • Cundy, K. C., Li, Z-H. and Lee, W. A. (1994) Effect of concomitant probenecid on the tissue distribution and urinary excretion of HPMPC in preclinical models. (Abstract). Pharm. Res. 11 (Suppl.), S449.
    • (1994) Pharm. Res. , vol.11 , Issue.SUPPL.
    • Cundy, K.C.1    Li, Z.H.2    Lee, W.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.