Canis familiaris telomerase reverse transcriptase undergoes alternative splicing

Mammalian Genome

Volumn 19, Issue 9, 2008, Pages 647-653

  Angelopoulou, Katerina ^a   Zavlaris, Michael ^a   Papaioannou, Nikolaos ^a   Vlemmas, Ioannis ^a  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; RNA; TELOMERASE REVERSE TRANSCRIPTASE;

ALTERNATIVE RNA SPLICING; AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BREAST; CANIS FAMILIARIS; CONTROLLED STUDY; DNA SEQUENCE; DOG; ENZYME ACTIVITY; ENZYME ANALYSIS; EXON; FEMALE; GENE DELETION; GENE INSERTION; GENETIC VARIABILITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ALTERNATIVE SPLICING; ANIMALS; BASE SEQUENCE; DNA PRIMERS; DNA, NEOPLASM; DOG DISEASES; DOGS; FEMALE; MAMMARY NEOPLASMS, ANIMAL; MOLECULAR SEQUENCE DATA; RNA, MESSENGER; SEQUENCE HOMOLOGY, NUCLEIC ACID; TELOMERASE;

ANIMALIA; CANIS FAMILIARIS;

EID: 63949084821     PISSN: 09388990     EISSN: 14321777     Source Type: Journal    
DOI: 10.1007/s00335-008-9144-7     Document Type: Article

References (32)

1. K Angelopoulou T Spiropoulou A Stathopoulou D Dimitropoulos N Malamos 2003 Development of a highly sensitive RT-PCR luminometric hybridization assay for human telomerase reverse-transcriptase beta-plus transcript Anticancer Res 23 4821 4830
2. DJ Argyle L Nasir 2003 Telomerase: a potential diagnostic and therapeutic tool in canine oncology Vet Pathol 40 1 7
3. A Bodnar M Ouellette M Frolkis S Holt C Chiu 1998 Extension of life-span by introduction of telomerase into normal human cells Science 279 349 352
4. L Colgin C Wilkinson A Englezou A Kilian M Robinson 2000 The hTERTα splice variant is a dominant negative inhibitor of telomerase activity Neoplasia 2 426 432
5. Y Funakoshi H Nakayama K Uetsuka R Nishimura N Sasaki 2000 Cellular proliferative and telomerase activity in canine mammary gland tumors Vet Pathol 37 177 183
6. RA Greenberg RC Allsopp L Chin GB Morin RA DePinho 1999 Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation Mol Cell Biol 19 3989 3997
7. W Hahn C Counter A Lundberg R Beijersbergen M Brooks 1999 Creation of human tumor cells with defined genetic elements Nature 400 464 468
8. H Hisatomi K Ohyashiki JH Ohyashiki K Nagao T Kanamaru 2003 Expression profile of a gamma-deletion variant of the human telomerase reverse transcriptase gene Neoplasia 5 193 197
9. A Kilian DD Bowtell HE Abud GR Hime DJ Venter 1997 Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types Hum Mol Genet 6 2011 2019
10. NW Kim MA Piatyszek KR Prowse CB Harley MD West 1994 Specific association of human telomerase activity with immortal cells and cancer Science 266 2011 2015
11. K Lindblad-Toh B Birren C Nusbaum A Abebe A Abouelleil 2005 Genome sequence, comparative analysis and haplotype structure of the domestic dog Nature 438 803 819
12. E Mavrogiannou A Strati A Stathopoulou EG Tsaroucha L Kaklamanis 2007 Real-time RT-PCR quantification of human telomerase reverse transcriptase splice variants in tumor cell lines and non-small cell lung cancer Clin Chem 53 53 61
13. M Meyerson CM Counter EM Eaton LW Ellisen P Steiner 1997 hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization Cell 90 785 795
14. TM Nakamura GB Morin KB Chapman SL Weinrich WH Andrews 1997 Telomerase catalytic subunit homologs from fission yeast and human Science 277 955 959
15. L Nasir 2008 Telomeres and telomerase: biological and clinical importance in dogs Vet J 175 155 163
16. L Nasir P Devlin T McKevitt G Rutteman DJ Argyle 2001 Telomere lengths and telomerase activity in dog tissues: a potential model system to study human telomere and telomerase biology Neoplasia 3 351 359
17. L Nasir E Gault S Campbell M Veeramalai D Gilbert 2004 Isolation and expression of the reverse transcriptase component of the Canis familiaris telomerase ribonucleoprotein (dogTERT) Gene 336 105 113
18. JC Poole LG Andrews TO Tollefsbol 2001 Activity, function, and gene regulation of the catalytic subunit of telomerase (hTERT) Gene 269 1 12
19. RJ Quinnell O Courtenay MA Shaw MJ Day LM Garcez 2001 Tissue cytokine responses in canine visceral leishmaniasis J Infect Dis 183 1421 1424
20. MG Renwick DJ Argyle S Long C Nixon EA Gault 2006 Telomerase activity and telomerase reverse transcriptase catalytic subunit expression in canine lymphoma: correlation with Ki67 immunoreactivity Vet Comp Oncol 4 141 150
21. S Sæbøe-Larssen E Fossberg G Gaudernack 2006 Characterization of novel alternative splicing sites in human telomerase reverse transcriptase (hTERT): analysis of expression and mutual correlation in mRNA isoforms from normal and tumour tissues BMC Mol Biol 7 26
22. MB Shapiro P Senepathy 1987 RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression Nucleic Acids Res 15 7155 7174
23. J Shay S Bacchetti 1997 A survey of telomerase activity in human cancer Eur J Cancer 33 787 791
24. T Spiropoulou L Ferekidou K Angelopoulou A Stathopoulou M Talieri 2004 Effect of antineoplastic agents on the expression of human telomerase reverse transcriptase beta plus transcript in MCF-7 cells Clin Biochem 37 299 304
25. G Ulaner JF Hu T Vu L Giudice A Hoffmann 1998 Telomerase activity in human development is regulated by human telomerase reverse transcriptase (hTERT) transcription and by alternate splicing of hTERT transcripts Cancer Res 58 4168 4172
26. AG Ulaner Hu Ji-F HT Vu H Oruganti CL Giudice 2000 Regulation of telomerase by alternative splicing of human telomerase reverse transcriptase (hTERT) in normal and neoplastic ovary, endometrium and myometrium Int J Cancer 85 330 335
27. J Weitzman M Yaniv 1999 Rebuilding the road to cancer Nature 400 401 402
28. M Wick D Zubov G Hagen 1999 Genomic organization and promoter characterization of the gene encoding the human telomerase reverse transcriptase (hTERT) Gene 232 97 106
29. M Yazawa M Okuda A Setoguchi R Nishimura N Sasaki 1999 Measurement of telomerase activity in dog tumors J Vet Med Sci 61 1125 1129
30. M Yazawa M Okuda A Setoguchi S Iwabuchi R Nishimura 2001 Telomere length and telomerase activity in canine mammary gland tumors Am J Vet Res 62 1539 1543
31. X Yi JW Shay WE Wright 2001 Quantitation of telomerase components and hTERT mRNA splicing patterns in immortal human cells Nucleic Acids Res 29 4818 4825
32. N Zaffaroni C Della Porta R Villa C Botti S Buglioni 2002 Transcription and alternative splicing of telomerase reverse transcriptase in benign and malignant breast tumours and in adjacent mammary glandular tissues: implications for telomerase activity J Pathol 198 37 46