Pathogenesis and therapy of autoimmunity-induced dilated cardiomyopathy

Frontiers in Bioscience

Volumn 14, Issue 5, 2009, Pages 1708-1715

  Zhao, Peng ^a,b   Sharma, Avadhesh C ^c   Ren, Jun ^b  

^a SHANDONG UNIVERSITY   (China)

^b UNIVERSITY OF WYOMING SCHOOL OF PHARMACY   (United States)

^c TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

Author keywords

Autoimmunity; Cardiac; Contractile function; Dilated cardiomyopathy; Review

Indexed keywords

AUTOANTIBODY; CALCIUM;

AUTOIMMUNE DISEASE; CONGESTIVE CARDIOMYOPATHY; GENETIC HETEROGENEITY; HEART MUSCLE; HUMAN; IMMUNOLOGY; METABOLISM; REVIEW;

AUTOANTIBODIES; AUTOIMMUNE DISEASES; CALCIUM; CARDIOMYOPATHY, DILATED; GENETIC HETEROGENEITY; HUMANS; MYOCARDIUM;

EID: 63849195319     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/3334     Document Type: Article

References (48)

1. Towbin JA, Bowles NE:Dilated cardiomyopathy: a tale of cytoskeletal proteins and beyond. J Cardiovasc Electrophysiol 17, 919-926 (2006). (Pubitemid 44079759)
2. Towbin JA, Bowles NE:Molecular diagnosis of myocardial disease. Expert Rev Mol Diagn 2, 587-602 (2002). (Pubitemid 35387850)
3. Mobini R, Maschke H, Waagstein F:New insights into the pathogenesis of dilated cardiomyopathy: possible underlying autoimmune mechanisms and therapy. Autoimmun Rev 3, 277-284 (2004). (Pubitemid 38887623)
4. Murphy RT, Mogensen J, Shaw A, Kubo T, Hughes S, McKenna WJ:Novel mutation in cardiac troponin I in recessive idiopathic dilated cardiomyopathy. Lancet 363, 371-372 (2004). (Pubitemid 38169547)
5. Mayosi BM, Somers K;Cardiomyopathy in Africa: heredity versus environment. Cardiovasc J Afr 18, 175-179 (2007).
6. Matsumori A, Furukawa Y, Hasegawa K, Sato Y, Nakagawa H, Morikawa Y, Miura K, Ohno Y, Tamakoshi A, Inaba Y, Sasayama S: Epidemiologic and clinical characteristics of cardiomyopathies in Japan: results from nationwide surveys. Circ J 66, 323-336 (2002).
7. Karkkainen S, Peuhkurinen K:Genetics of dilated cardiomyopathy. Ann Med 39, 91-107 (2007). (Pubitemid 46598173)
8. Bers DM:Calcium Cycling and Signaling in Cardiac Myocytes. Annu Rev Physiol 70, 23-49 (2008). (Pubitemid 351738170)
9. Bers DM:Cardiac excitation-contraction coupling. Nature 415, 198-205 (2002). (Pubitemid 34059525)
10. Shimizu M, Ino H, Yasuda T, Fujino N, Uchiyama K, Mabuchi T, Konno T, Kaneda T, Fujita T, Masuta E, Katoh M, Funada A, Mabuchi H:Gene mutations in adult Japanese patients with dilated cardiomyopathy. Circ J 69, 150-153 (2005). (Pubitemid 40313032)
11. Rajan S, Ahmed RP, Jagatheesan G, Petrashevskaya N, Boivin GP, Urboniene D, Arteaga GM, Wolska BM, Solaro RJ, Liggett SB, Wieczorek DF:Dilated cardiomyopathy mutant tropomyosin mice develop cardiac dysfunction with significantly decreased fractional shortening and myofilament calcium sensitivity.Circ Res 101, 205-214 (2007). (Pubitemid 47196588)
12. Feldman AM, McNamara D: Myocarditis. N Engl J Med 343, 1388-1398 (2000).
13. Li SY, Yang X, Ceylan-Isik AF, Du M, Sreejayan N, Ren J:Cardiac contractile dysfunction in Lep/Lep obesity is accompanied by NADPH oxidase activation, oxidative modification of sarco (endo)plasmic reticulum Ca2+-ATPase and myosin heavy chain isozyme switch. Diabetologia 49, 1434-1446 (2006).
14. Veeraveedu PT, Watanabe K, Ma M, Palaniyandi SS, Yamaguchi K, Suzuki K, Kodama M, Aizawa Y:Torasemide, a long-acting loop diuretic, reduces the progression of myocarditis to dilated cardiomyopathy. Eur J Pharmacol 581, 121-131 (2008).
15. Noutsias M, Seeberg B, Schultheiss HP, Kuhl U:Expression of cell adhesion molecules in dilated cardiomyopathy: evidence for endothelial activation in inflammatory cardiomyopathy. Circulation 99, 2124-2131 (1999). (Pubitemid 29196796)
16. Wojnicz R, Nowalany-Kozielska E, Wodniecki J, Szczurek-Katański K, Nozyński J, Zembala M, Rozek MM:Immunohistological diagnosis of myocarditis. Potential role of sarcolemmal induction of the MHC and ICAM-1 in the detection of autoimmune mediated myocyte injury. Eur Heart J 19, 1564-1572 (1998). (Pubitemid 28470479)
17. Caforio AL, Bonifacio E, Stewart JT, Neglia D, Parodi O, Bottazzo GF, McKenna WJ:Novel organ-specific circulating cardiac autoantibodies in dilated cardiomyopathy. J Am Coll Cardiol 15, 1527-1534 (1990). (Pubitemid 20174312)
18. Omerovic E, Bollano E, Andersson B, Kujacic V, Schulze W, Hjalmarson A, Waagstein F, Fu M:Induction of cardiomyopathy in severe combined immunodeficiency mice by transfer of lymphocytes from patients with idiopathic dilated cardiomyopathy. Autoimmunity 32, 271-280 (2000). (Pubitemid 32043782)
19. Eriksson U, Penninger JM:Autoimmune heart failure: new understandings of pathogenesis. Int J Biochem Cell Biol 37, 27-32 (2005). (Pubitemid 39286019)
20. Freedman NJ, Lefkowitz RJ:Anti-beta (1)-adrenergic receptor antibodies and heart failure: causation, not just correlation. J Clin Invest 113, 1379-1382 (2004). (Pubitemid 39071690)
21. Jahns R, Boivin V, Hein L, Triebel S, Angermann CE, Ertl G, Lohse MJ:Direct evidence for a beta 1-adrenergic receptor-directed autoimmune attack as a cause of idiopathic dilated cardiomyopathy. J Clin Invest 113, 1419-1429 (2004). (Pubitemid 39071697)
22. Jahns R, Boivin V, Siegmund C, Inselmann G, Lohse MJ, Boege F:Autoantibodies activating human beta1-adrenergic receptors are associated with reduced cardiac function in chronic heart failure. Circulation 99, 649-654 (1999). (Pubitemid 29077363)
23. Chiale PA, Ferrari I, Mahler E, Vallazza MA, Elizari MV, Rosenbaum MB, Levin MJ:Differential profile and biochemical effects of antiautonomic membrane receptor antibodies in ventricular arrhythmias and sinus node dysfunction. Circulation 103, 1765-1771 (2001). (Pubitemid 32291414)
24. Iwata M, Yoshikawa T, Baba A, Anzai T, Mitamura H, Ogawa S:Autoantibodies against the second extracellular loop of beta1-adrenergic receptors predict ventricular tachycardia and sudden death in patients with idiopathic dilated cardiomyopathy. J Am Coll Cardiol 37, 418-424 (2001).
25. Lohse MJ, Engelhardt S, Eschenhagen T:What is the role of beta-adrenergic signaling in heart failure? Circ Res 93, 896-906 (2003). (Pubitemid 37433227)
26. Christ T, Wettwer E, Dobrev D, Adolph E, Knaut M, Wallukat G, Ravens U:Autoantibodies against the beta1 adrenoceptor from patients with dilated cardiomyopathy prolong action potential duration and enhance contractility in isolated cardiomyocytes. J Mol Cell Cardiol 33, 1515-1525 (2001). (Pubitemid 32681669)
27. Nakayama H, Chen X, Baines CP, Klevitsky R, Zhang X, Zhang H, Jaleel N, Chua BH, Hewett TE, Robbins J, Houser SR, Molkentin JD:Ca2+ and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure. J Clin Invest 117, 2431-2444 (2007). (Pubitemid 47494345)
28. Buse C, Altmann F, Amann B, Hauck SM, Poulsen Nautrup C, Ueffing M, Stangassinger M, Deeg CA:Discovering novel targets for autoantibodies in dilated cardiomyopathy. Electrophoresis 29, 1325-1332 (2008). (Pubitemid 351461086)
29. Monserrat L, Hermida-Prieto M, Fernandez X, Rodríguez I, Dumont C, Cazón L, Cuesta MG, Gonzalez-Juanatey C, Peteiro J, Alvarez N, Penas-Lado M, Castro-Beiras A:Mutation in the alpha-cardiac actin gene associated with apical hypertrophic cardiomyopathy, left ventricular noncompaction, and septal defects. Eur Heart J 28, 1953-1961 (2007). (Pubitemid 47579548)
30. Kallwellis-Opara A, Staudt A, Trimpert C, Noutsias M, Kühl U, Pauschinger M, Schultheiss HP, Grube M, Böhm M, Baumann G, Völker U, Kroemer HK, Felix SB.:Immunoadsorption and subsequent immunoglobulin substitution decreases myocardial gene expression of desmin in dilated cardiomyopathy. J Mol Med 85:1429-1435 (2007). (Pubitemid 350234098)
31. Liao YH, Cheng LX, Dai SP, Tu YS:Autoantibodies against ADP/ATP carrier from patients with dilated cardiomyopathy increase activity of voltage-dependent Ca channels in isolated cardiac myocytes. Blood Press Suppl 3, 41-44 (1996).
32. Yuan J, Liao YH, Wang ZH, Cheng X, Zhang JH, Dong JH, Wang M:Effects of immunotherapy with anti-L3T4 monoclonal antibody on autoimmune cardiomyopathy: experiment with mice. Zhonghua Yi Xue Za Zhi 85, 3346-3349 (2005). (Pubitemid 43224329)
33. Rose NR:Autoimmunity in coxsackievirus infection. Curr Top Microbiol Immunol 323, 293-314 (2008).
34. Olson TM, Michels VV, Thibodeau SN, Tai YS, Keating MT:Actin mutations in dilated cardiomyopathy, a heritable form of heart failure. Science 280, 750-752 (1998). (Pubitemid 28243352)
35. Hanson EL, Jakobs PM, Keegan H, Coates K, Bousman S, Dienel NH, Litt M, Hershberger RE:Cardiac troponin T lysine 210 deletion in a family with dilated cardiomyopathy. J Card Fail 8, 28-32 (2002). (Pubitemid 34163847)
36. Daehmlow S, Erdmann J, Knueppel T, Gille C, Froemmel C, Hummel M, Hetzer R, Regitz-Zagrosek V:Novel mutations in sarcomeric protein genes in dilated cardiomyopathy. Biochem Biophys Res Commun 298, 116-120 (2002). (Pubitemid 35205395)
37. Kamisago M, Sharma SD, DePalma SR, Solomon S, Sharma P, McDonough B, Smoot L, Mullen MP, Woolf PK, Wigle ED, Seidman JG, Seidman CE:Mutations in sarcomere protein genes as a cause of dilated cardiomyopathy. N Engl J Med 343, 1688-1696 (2000).
38. Mohapatra B, Jimenez S, Lin JH, Bowles KR, Coveler KJ, Marx JG, Chrisco MA, Murphy RT, Lurie PR, Schwartz RJ, Elliott PM, Vatta M, McKenna W, Towbin JA, Bowles NE: Mutations in the muscle LIM protein and alpha-actinin-2 genes in dilated cardiomyopathy and endocardial fibroelastosis. Mol Genet Metab 80, 207-215 (2003). (Pubitemid 37272247)
39. Mogensen J, Murphy RT, Shaw T, Bahl A, Redwood C, Watkins H, Burke M, Elliott PM, McKenna WJ:Severe disease expression of cardiac troponin C and T mutations in patients with idiopathic dilated cardiomyopathy. J Am Coll Cardiol 44, 2033-2040 (2004). (Pubitemid 39473290)
40. Wakayama Y, Miura M, Sugai Y, Kagaya Y, Watanabe J, ter Keurs HE, Shirato K:Stretch and quick release of rat cardiac trabeculae accelerates Ca2+ waves and triggered propagated contractions. Am J Physiol Heart Circ Physiol 281, H2133-H2142 (2001).
41. Pogwizd SM, Bers DM:Cellular basis of triggered arrhythmias in heart failure. Trends Cardiovasc Med 14, 61-66 (2004). (Pubitemid 38340848)
42. Caforio AL, Iliceto S:Genetically determined myocarditis: clinical presentation and immunological characteristics. Curr Opin Cardiol 23, 219-226 (2008). (Pubitemid 351492465)
43. Frishman WH, O'Brien M, Naseer N, Anandasabapathy S:Innovative drug treatments for viral and autoimmune myocarditis. Heart Dis 4, 171-183 (2002). (Pubitemid 34670485)
44. Fu M:Autoimmunity in idiopathic dilated cardiomyopathy: from patients to molecules and back to patients. Int J Cardiol 112, 1 (2006). (Pubitemid 44262407)
45. Pauschinger M, Rutschow S, Chandrasekharan K, Westermann D, Weitz A, Peter Schwimmbeck L, Zeichhardt H, Poller W, Noutsias M, Li J, Schultheiss HP, Tschope C:Carvedilol improves left ventricular function in murine coxsackievirus-induced acute myocarditis association with reduced myocardial interleukin-1beta and MMP-8 expression and a modulated immune response. Eur J Heart Fail 7, 444-452 (2005). (Pubitemid 40732970)
46. Staudt A, Böhm M, Knebel F, Grosse Y, Bischoff C, Hummel A, Dahm JB, Borges A, Jochmann N, Wernecke KD, Wallukat G, Baumann G, Felix SB:Potential role of autoantibodies belonging to the immunoglobulin G-3 subclass in cardiac dysfunction among patients with dilated cardiomyopathy. Circulation 106, 2448-2453 (2002). (Pubitemid 35278800)
47. Felix SB, Staudt A, Dörffel WV, Stangl V, Merkel K, Pohl M, Döcke WD, Morgera S, Neumayer HH, Wernecke KD, Wallukat G, Stangl K, Baumann G:Hemodynamic effects of immunoadsorption and subsequent immunoglobulin substitution in dilated cardiomyopathy: three-month results from a randomized study. J Am Coll Cardiol 35, 1590-1598 (2000). (Pubitemid 30307505)
48. Staudt A, Schäper F, Stangl V, Plagemann A, Böhm M, Merkel K, Wallukat G, Wernecke KD, Stangl K, Baumann G, Felix SB:Immunohistological changes in dilated cardiomyopathy induced by immunoadsorption therapy and subsequent immunoglobulin substitution. Circulation 103, 2681-2686 (2001). (Pubitemid 32538782)