Risk loci for type 2 diabetes - Quo vadis?

Clinical Chemistry and Laboratory Medicine

Volumn 47, Issue 4, 2009, Pages 383-386

  Weijers, Rob N M ^a  

^a ONZE LIEVE VROUWE GASTHUIS   (Netherlands)

Author keywords

Genome wide association study; Mitochondrion; Pancreatic cell function; Single nucleotide polymorphism; Type 2 diabetes

Indexed keywords

CARRIER PROTEIN; CDK5 REGULATORY SUBUNIT ASSOCIATED PROTEIN 1 LIKE 1; CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLIN DEPENDENT KINASE INHIBITOR 2B; HOMEODOMAIN PROTEIN; HUMAN HEMATOPOIETICALLY EXPRESSED HOMEOBOX PROTEIN; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; REGULATOR PROTEIN; SLC30A8 PROTEIN; TRANSCRIPTION FACTOR 7 LIKE 2; UNCLASSIFIED DRUG;

ARTICLE; GENE LOCUS; GENETIC RISK; GENETIC SUSCEPTIBILITY; HUMAN; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PATHOGENESIS; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

ANIMALS; CATION TRANSPORT PROTEINS; CYCLIN-DEPENDENT KINASE INHIBITOR PROTEINS; DIABETES MELLITUS, TYPE 2; HOMEODOMAIN PROTEINS; HUMANS; INSULIN-SECRETING CELLS; POLYMORPHISM, SINGLE NUCLEOTIDE; TCF TRANSCRIPTION FACTORS;

EID: 63849152755     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/CCLM.2009.077     Document Type: Article

References (29)

1. Saxena R, Voight BF, Lyssenko V, Burtt NP, de Bakker PI, Chen H, et al. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 2007;316:1331-6.
2. Zeggini E, Weedon MN, Lindgren CM, Frayling TM, Elliott KS, Lango H, et al. Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 2007;316:1336-41.
3. Scott LJ, Mohlke KL, Bonnycastle LL, Willer CJ, Li Y, Duren WL, et al. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 2007;316:1341-5.
4. Zeggini E, Scott LJ, Saxena R, Voight BF. Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet 2008;40:638-45.
5. Suzuki H, Zhou X, Yin J, Lei J, Jiang HY, Suzuki Y, et al. Intragenic mutations of CDKN2B and CDKN2A in primary human esophageal cancers. Hum Mol Genet 1995; 10:1883-7.
6. Watson JD, Baker TA, Bell SP, Gann A, Levine M, Losick R, editors. Molecular biology of the gene, 6th ed. Cold Spring Harbor: Cold Spring Harbor Laboratory Press, 2008:589-632.
7. Adjaye J, Monk M. Transcription of homeobox-containing genes detected in cDNA libraries derived from human unfertilized oocytes and preimplantation embryos. Mol Hum Reprod 2000;8:707-11.
8. Bort R, Martinez-Barbera JP, Beddington RS, Zaret KS. Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas. Development 2003;131:797-806.
9. Steinthorsdottir V, Reynisdottir I, Thorleifsson G, Ghosh S, Benediktsson R, Sigurdsson G, et al. The type 2 diabetes gene CDKAL1 discovered by genome-wide association is expressed in beta cells and modulated by glucose concentration. Circulation 2007;116:II-507.
10. Ubeda M, Rukstalis JM, Habener JF. Inhibition of cyclindependent kinase 5 activity protects pancreatic beta cells from glucotoxity. J Biol Chem 2006;281:28858-64.
11. Watson JD, Baker TA, Bell SP, Gann A, Levine M, Losick R, editors. Molecular biology of the gene, 6th ed. Cold Spring Harbor: Cold Spring Harbor Laboratory Press, 2008:415-56.
12. Watson JD, Baker TA, Bell SP, Gann A, Levine M, Losick R, editors. Molecular biology of the gene, 6th ed. Cold Spring Harbor: Cold Spring Harbor Laboratory Press, 2008:633-60.
13. Smith U. TCF7L2 and type 2 diabetes - we WNT to know. Diabetologia 2007;50:5-7.
14. Cauchi S, Meyre D, Dina C, Choquet H, Samson C, Gallina S, et al. Transcription factor TCF7L2 genetic study in the French population. Diabetes 2006;55:2903-8.
15. Florez JC. Newly identified loci highlight beta cell dysfunction as a key cause of type 2 diabetes: where are the insulin resistance genes? Diabetologia 2008;51:1100-10.
16. Lu M, Fu D. Structure of the zink transporter YiiP. Science 2007;317:1746-8.
17. Chimienti F, Devergnas S, Favier A, Seve M. Identification and cloning of a β-cell - specific zinc transporter, ZnT-8, localized into insulin secretory granules. Diabetes 2004;53:2330-7.
18. + channels and disease: from molecule to malady. Am J Physiol Endocrinol Metab 2007;293:E880-9.
19. Proks P, Capener CE, Jones P, Ashcroft FM. Mutations within the P-loop of Kir6.2 modulate the intraburst kinetics of the ATP-sensitive potassium channel. J Gen Physiol 2001;118:341-53.
20. ATP channels: control of nucleotide sensitivity by the N-terminal domain of the Kir6.2 subunit. J Physiol 1999;515:19-30.
21. Staiger H, Machicao F, Kantartzis K, Schäfer SA, Kirchhoff K, Guthoff M, et al. Novel meta-analysis-derived type 2 diabetes risk loci do not determine prediabetic phenotypes. PLoS ONE 2008;3:e3019.
22. Nicolae DL, Wen X, Voight F, Cox NJ. Coverage and characteristics of the Affymetrix GeneChip Human Mapping 100K SNP set. PLoS Genet 2006;2:e67.
23. Meigs JB, Manning AK, Fox CS, Florez JC, Liu C, Cupples LA, et al. Genome-wide association with diabetes-related traits in the Framingham Heart Study. BMC Med Genet 2007;8(Suppl 1):S16.
24. Williams SM, Canter JA, Crawford DC, Moore JH, Ritchie MD, Haines JL. Problems with genome-wide association studies wletterx. Science 2007;316:1841-2.
25. Patti ME, Butte AJ, Crunkhorn S, Cusi K, Berria R, Kashyap S, et al. Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: potential role of PGC1 and NRF1. Proc Natl Acad Sci USA 2003;100:8466-71.
26. Shi X, Burkart A, Nicoloro SM, Czech MP, Straubhaar J, Corvera S. Paradoxical effect of mitochondrial respiration chain impairment on insulin signaling and glucose transport in adipose cells. J Biol Chem 2008;283:30658-67.
27. Wiley S, Murphy AN, Ross SA, van der Geer P, Dixon JE. MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity. Proc Natl Acad Sci USA 2007;104:5318-23.
28. Yki-Järvinen H. Pathogenesis of non-insulin-dependent diabetes mellitus. Lancet 1994;34:91-5.
29. Weijers RN, Bekedam DJ. Relationship between gestational diabetes mellitus and type 2 diabetes. Clin Chem 2007;53:377-83.