IL-6 deficiency increases fatty acid transporters and intramuscular lipid content in red but not white skeletal muscle

Journal of Physiology and Pharmacology

Volumn 59, Issue SUPPL. 7, 2008, Pages 105-117

  Chabowski, A ^a   Zmijewska, M ^a   Gorski, J ^a   Bonen, A ^b   Kaminski, K ^a   Kozuch, M ^a   Winnicka, M M ^a  

^a MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

^b UNIVERSITY OF GUELPH   (Canada)

Author keywords

FABPpm; FAT CD36; IL 6; Lipids

Indexed keywords

DIACYLGLYCEROL; FATTY ACID; FATTY ACID TRANSPORTER; GENOMIC DNA; INTERLEUKIN 6; LIPID; SATURATED FATTY ACID; TRIACYLGLYCEROL; CD36 ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; BLOOD SAMPLING; CONCENTRATION (PARAMETERS); CONFERENCE PAPER; CONTROLLED STUDY; DNA ISOLATION; ENZYME DEFICIENCY; FAST MUSCLE; GASTROCNEMIUS MUSCLE; GENOTYPE; LIPID COMPOSITION; LIPID OXIDATION; LIPID STORAGE; LIPID TRANSPORT; MOUSE; MUSCLE CELL; NONHUMAN; PROTEIN EXPRESSION; SKELETAL MUSCLE; SLOW MUSCLE; SOLEUS MUSCLE; WESTERN BLOTTING; AGE; ANIMAL; ARTICLE; C57BL MOUSE; FEMALE; GENETICS; METABOLISM; MOUSE MUTANT;

AGE FACTORS; ANIMALS; ANTIGENS, CD36; DIGLYCERIDES; FATTY ACID TRANSPORT PROTEINS; FATTY ACIDS, NONESTERIFIED; FEMALE; INTERLEUKIN-6; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUSCLE, SKELETAL; TRIGLYCERIDES;

EID: 63649139329     PISSN: 08675910     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (42)

1. Dyck DJ, Heigenhauser GJ, Bruce CR. The role of adipokines as regulators of skeletal muscle fatty acid metabolism and insulin sensitivity. Acta Physiol 2006; 186: 5-16.
2. Pedersen B, Fischer CP. Beneficial health effects of exercise - the role of IL-6 as a myokine. Trends Pharmacol Sci 2007; 4: 152-156. (Pubitemid 46505167)
3. Pedersen B, Fischer CP. Physiological roles of muscle-derived interleukin-6 in response to exercise. Curr Opin Clin Nutr Metab Car 2007; 10: 265-271. (Pubitemid 46596700)
4. Al-Khalili L, Bouzakri K, Glund S, Lonnqvist F, Koistinen HA, Krook A. Signaling specificity of interleukin-6 action on glucose and lipid metabolism in skeletal muscle. Mol Endocrinol 2006; 20: 3364-3375.
5. Bruce CR, Dyck DJ. Cytokine regulation of skeletal muscle fatty acid metabolism: effect of interleukin-6 and tumor necrosis factor-alpha. Am J Physiol Endocrinol Metab 2004; 287: E616-E621. (Pubitemid 39237888)
6. Kern PA, Ranganathan S, Li C, Wood L, Ranganathan G. Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance. Am J Physiol Endocrinol Metab 2001; 280: E745-E751. (Pubitemid 32466842)
7. Vozarova B, Weyer C, Hanson K, Tataranni PA, Bogardus C, Pratley RE. Circulating interleukin- 6 in relation to adiposity, insulin action, and insulin secretion. Obes Res 2001; 9: 414-417. (Pubitemid 33603868)
8. Glund S, Krook A. Role of interleukin-6 signalling in glucose and lipid metabolism. Acta Physiol (Oxf) 2008; 192: 37-48. (Pubitemid 350265360)
9. Maggio M, Guralnik JM, Longo DL, Ferrucci L. Interleukin-6 in aging and chronic disease: a magnificent pathway. J Gerontol A Biol Sci Med Sci 2006; 61: 575-584. (Pubitemid 43912095)
10. Wallenius V, Wallenius K, Ahrén B, et al. Interleukin-6-deficient mice develop mature-onset obesity. Nat Med 2002; 8: 75-79. (Pubitemid 34101732)
11. Di Gregorio GB, Hensley L, Lu T, Ranganathan G., Kern PA. Lipid and carbohydrate metabolism in mice with a targeted mutation in the IL-6 gene: absence of development of age-related obesity. Am J Physiol 2004; 287: E182-E190. (Pubitemid 38856299)
12. Villareal DT, Apovian CM, Kushner RF, Klein S. American Society for Nutrition; NAASO, The Obesity Society. Obesity in older adults: technical review and position statement of the American Society for Nutrition and NAASO, The Obesity Society. Obes Res 2005; 13: 1849-1863.
13. Bechtold M, Palmer J, Valtos J, Iasiello C, Sowers J. Metabolic syndrome in the elderly. Curr Diab Rep 2006; 6: 64-71.
14. Kelley DE, Goodpaster B, Wing RR, Simoneau JA. Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss. Am J Physiol 1999; 277: E1130-E1141. (Pubitemid 30046009)
15. Kim JY, Hickner RC, Cortright RL, Dohm GL, Houmard JA. Lipid oxidation is reduced in obese human skeletal muscle. Am J Physiol Endocrinol Metab 2000; 279: E1039-E1044.
16. Kelley DA, Mandarino LJ. Fuel selection in human skeletal muscle in insulin resistance. A reexamination. Diabetes 2000; 49: 677-683. (Pubitemid 30339979)
17. Bonen A, Parolin ML, Steinberg GR, et al. Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal FAT/CD36. FASEB J 2004; 18: 1144-1146. (Pubitemid 39561551)
18. Luiken JJFP, Arumugam Y, Dyck DJ, et al. Increased rates of fatty acid uptake and plasmalemmal fatty acid transporters in obese Zucker rats. J Biol Chem 2001; 276: 40567-40573. (Pubitemid 37373196)
19. Han XX, Chabowski A, Tandon NN, et al. Metabolic challenges reveal impaired fatty acid metabolism and translocation of FAT/CD36 but not FABPpm in obese Zucker rat muscle. Am J Physiol Endocrinol Metab 2007; 293: E566-E575. (Pubitemid 47205101)
20. Chabowski A, Chatham JC, Tandon NN, et al. Fatty acid transport and FAT/CD36 are increased in red but not in white skeletal muscle of ZDF rats. Am J Physiol Endocrinol Metab 2006; 291: E675-E682. (Pubitemid 44352276)
21. Bonen A, Luiken JJ, Liu S, et al. Palmitate transport and fatty acid transporters in red and white muscles. Am J Physiol 1998; 275: E471-E478. (Pubitemid 128734210)
22. Bonen A, Chabowski A, Luiken JJ, Glatz JF. Is membrane transport of FFA mediated by lipid, protein, or both? Mechanisms and regulation of protein-mediated cellular fatty acid uptake: molecular, biochemical, and physiological evidence. Physiology 2007; 22: 15-29.
23. Hegarty BD, Cooney GJ, Kraegen EW, Furler SM. Increased efficiency of fatty acid uptake contributes to lipid accumulation in skeletal muscle of high fat-fed insulin-resistant rats. Diabetes 2002; 51: 1477-1484.
24. Bonen A, Han XX, Habets DD, Febbraio M, Glatz JF, Luiken JJ. A null mutation in skeletal muscle FAT/CD36 reveals its essential role in insulin- and AICAR-stimulated fatty acid metabolism. Am J Physiol Endocrinol Metab 2007; 292: E1740-E1749. (Pubitemid 47084709)
25. Wilkes J, Bonen A, Bell RC. A modified high-fat diet induces insulin resistance in rat skeletal muscle but not adipocytes. Am J Physiol Endocrinol Metab 1998; 275: E679-E686. (Pubitemid 28500705)
26. Henriksen EJ, Kinnick TR, Teachey MK, et al. Modulation of muscle insulin resistance by selective inhibition of GSK-3 in Zucker diabetic fatty rats. Am J Physiol Endocrinol Metab 2003; 284: E892-E900. (Pubitemid 36444024)
27. Calles-Escandon J, Sweet L, Ljungqvist O, Hirshman MF. The membrane associated 40 kDa fatty acid binding protein is present in human skeletal muscle. Life Sci 1996; 58: 19-28.
28. Folch J, Lees M, Stanley GHS. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 1957; 226: 497-509.
29. Van der Vusse GJ, Roemen THM, Reneman RS. Assessment of fatty acids in dog left ventricular myocardium. Biochim Biophys Acta 1980; 617: 347-352. (Pubitemid 10096460)
30. Alkhateeb H, Chabowski A, Bonen A. Viability of the isolated soleus muscle during long-term incubation. Appl Physiol Nutr Metab 2006; 31: 467-476.
31. Bonen A, Nickerson JG, Momken I, et al. Tissue-specific and fatty acid transporter-specific changes in heart and soleus muscle over a 1-yr period. Mol Cell Biochem 2006; 291: 145-154.
32. Faldt J, Wernstedt I, Fitzgerald SM, Wallenius K, Bergström G, Jansson JO. Reduced exercise endurance in interleukin-6-deficient mice. Endocrinology 2004; 145: 2680-2686. (Pubitemid 38686214)
33. Luiken JJ, Turcotte LP, Bonen A. Protein-mediated palmitate uptake and expression of fatty acid transport proteins in heart giant vesicles. J Lipid Res 1999; 40: 1007-1016. (Pubitemid 29287871)
34. Jove M, Planavila A, Sanchez RM, Merlos M, Laguna JC, Vazquez-Carrera M. Palmitate induces tumor necrosis factor-alpha expression in C2C12 skeletal muscle cells by a mechanism involving protein kinase C and nuclear factor-kappaB activation. Endocrinology 2006; 147: 552-561. (Pubitemid 43004310)
35. Steensberg A, Keller C, Starkie RL, Osada T, Febbraio MA, Pedersen BK. IL-6 and TNF-alpha expression in, and release from, contracting human skeletal muscle. Am J Physiol Endocrinol Metab 2002; 283: E1272-E1278. (Pubitemid 35340635)
36. Ruderman NB, Keller C, Richard AM, et al. Potential Role in the Systemic Response to Exercise and Prevention of the Metabolic Syndrome. Diabetes 2006; 55: S48-S54.
37. Kelly M, Keller C, Avilucea PR, et al. AMPK activity is diminished in tissues of IL-6 knockout mice: the effect of exercise. Biochem Biophys Res Commun 2004; 320: 449-454. (Pubitemid 38798888)
38. Schmitz-Peiffer C, Browne CL, Oakes ND, et al. Alterations in the expression and cellular localization of protein kinase C isoforms e and q are associated with insulin resistance in skeletal muscle of the high-fat-fed rat. Diabetes 1997; 46: 169-178. (Pubitemid 27272248)
39. Itani SI, Ruderman NB, Schmieder F, Boden G. Lipid-induced insulin resistance in human muscle is associated with changes in diacylglyceol, protein kinase C, and IkB-α. Diabetes 2002; 51: 2005-2011. (Pubitemid 34729001)
40. Matsui H, Okumura K, Kawakami K, Hibino M, Toki Y, Ito T. Improved insulin sensitivity by bezafibrate in rats: relationship to fatty acid composition of skeletal-muscle triglycerides. Diabetes 1997; 46: 348-353. (Pubitemid 27090261)
41. Chavez JA, Summers SA. Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes. Arch Biochem Biophys 2003; 419: 101-109. (Pubitemid 37329976)
42. Lee JS, Pinnamaneni SK, Eo SJ, et al. Saturated, but not n-6 polyunsaturated, fatty acids induce insulin resistance: role of intramuscular accumulation of lipid metabolites. J Appl Physiol 2006; 100: 1467-1474.