Development of in vitro models for investigating spatially fractionated irradiation: Physics and biological results

Physics in Medicine and Biology

Volumn 54, Issue 6, 2009, Pages 1565-1578

  Blockhuys, S ^a   Vanhoecke, B ^a   Paelinck, L ^a   Bracke, M ^a   De Wagter, C ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

96 WELLS; BIOLOGICAL DOSE; DOSE DISTRIBUTIONS; DOSE GRADIENTS; DOSE RANGES; EXPERIMENTAL MODELS; FORMAZAN; FRACTIONATED IRRADIATIONS; GRADIENT MODELS; HUMAN BREAST CANCER CELLS; IN-VITRO; METABOLIC ACTIVITIES; MTT ASSAYS; OPTICAL DENSITIES; SPECIFIC EFFECTS; STEEP GRADIENTS; X-RAY DOSE;

BIOLOGICAL RADIATION EFFECTS; IRRADIATION;

METABOLISM;

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; FORMAZAN;

ARTICLE; BREAST CANCER; CANCER CELL; CONTROLLED STUDY; DOSIMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; RADIATION DOSE; RADIATION DOSE DISTRIBUTION;

CELL LINE, TUMOR; DOSE FRACTIONATION; HUMANS; MODELS, BIOLOGICAL; PHYSICAL PROCESSES; RADIATION DOSAGE;

EID: 63649110359     PISSN: 00319155     EISSN: 13616560     Source Type: Journal    
DOI: 10.1088/0031-9155/54/6/011     Document Type: Article

References (18)

1. Bewes J M, Suchowerska N, Jackson M, Zhang M and McKenzie D R 2008 The radiobiological effect of intra-fraction dose-rate modulation in intensity modulated radiation therapy (IMRT) Phys. Med. Biol. 53 3567-78
2. Bracke M E, Depypere H, Labit C, Van Marck V, Vennekens K, Vermeulen S J, Maelfait I, Philippé J, Serreyn R and Mareel M M 1997 Functional downregulation of the E-cadherin/catenin complex leads to loss of contact inhibition of motility and of mitochondrial activity, but not of growth in confluent epithelial cell cultures Eur. J. Cell. Biol. 74 342-9
3. Bromley R, Davey R, Oliver L, Harvie R and Baldock C 2006 A preliminary investigation of cell growth after irradiation using a modulated x-ray intensity pattern Phys. Med. Biol. 51 3639-51
4. Byhardt R W, Martin L, Pajak T F, Shin K H, Emami B and Cox J D 1993 The influence of field-size and other treatment factors on pulmonary toxicity following hyper-fractionated irradiation for inoperable nonsmall cell-lung cancer (NSCLC)-analysis of a radiation-therapy oncology group (RTOG) protocol Int. J. Radiat. Oncol. Biol. Phys. 27 537-44
5. Dilmanian F A, Morris G M, Zhong N, Bacarian T, Hainfeld J F, Kalef-Ezra J, Brewington L J, Tammam J and Rosen E M 2003 Murine EMT-6 carcinoma: high therapeutic efficacy of microbeam radiation therapy Radiat. Res. 159 632-41
6. 99mTc-MIBI 2004 Cancer Lett. 212 105-11
7. Gong B, Chen Q and Almasan A 1998 Ionizing radiation stimulates mitochondrial gene expression and activity Radiat. Res. 150 505-12
8. Hall E J 2000 Radiobiology for the Radiologist (Philadelphia, PA: Lippincott Williams and Wilkins)
9. Mackonis E C, Suchowerska N, Zhang M, Ebert M, McKenize D R and Jackson M 2007 Cellular response to modulated radiation fields Phys. Med. Biol. 52 5469-82
10. Madani I, De Neve W and Mareel M 2008 Does ionizing radiation stimulate cancer invasion and metastasis Bull. Cancer 95 292-300
11. Moiseenko V, Duzenli C and Durand R E 2007 In vitro study of cell survival following dynamic MLC intensity-modulated radiation therapy dose delivery Med. Phys. 34 1514-20
12. Morgan W F and Sowa M B 2007 Non-targeted bystander effects induced by ionizing radiation Mutat. Res. 616 159-64
13. Paelinck L, De Neve W and De Wagter C 2007 Precautions and strategies in using a commercial flatbed scanner for radiochromic film dosimetry Phys. Med. Biol. 52 231-42
14. Paelinck L, Reynaert N, Thierens H, De Wagter C and De Neve W 2003 The value of radiochromic film dosimetry around air cavities: experimental results and Monte Carlo simulations Phys. Med. Biol. 48 1895-905
15. Slater T 1963 Studies on a succinate-neotetrazolium reductase system of rat liver: II. Points of coupling with the respiratory chain Biochem. Biophys. Acta 77 365-82
16. Suchowerska N, Ebert M A, Zhang M and Jackson M 2005 In vitro response of tumour cells to non-uniform irradiation Phys. Med. Biol. 50 3041-51
17. Tomic N, Gosselin M, Wan J F, Saragovi U, Podgorsak E B, Evans M and Devic S 2007 Verification of cell irradiation dose deposition using a radiochromic film Phys. Med. Biol. 52 3121-31
18. Wild-Bode C, Weller M, Rimner A, Dichgans J and Wick W 2001 Sublethal irradiation promotes migration and invasiveness of glioma cells: implications for radiotherapy of human glioblastoma Cancer Res. 61 2744-50