-
1
-
-
18744371544
-
The levels of mature glycosylated nicastrin are regulated and correlate with gamma-secretase processing of amyloid beta-precursor protein
-
Arawaka S., Hasegawa H., Tandon A., Janus C., Chen F., Yu G., Kikuchi K., Koyama S., Kato T., Fraser P.E., and St George-Hyslop P. The levels of mature glycosylated nicastrin are regulated and correlate with gamma-secretase processing of amyloid beta-precursor protein. J. Neurochem. 83 (2002) 1065-1071
-
(2002)
J. Neurochem.
, vol.83
, pp. 1065-1071
-
-
Arawaka, S.1
Hasegawa, H.2
Tandon, A.3
Janus, C.4
Chen, F.5
Yu, G.6
Kikuchi, K.7
Koyama, S.8
Kato, T.9
Fraser, P.E.10
St George-Hyslop, P.11
-
2
-
-
0025863618
-
Neuropathological stageing of Alzheimer-related changes
-
Braak H., and Braak E. Neuropathological stageing of Alzheimer-related changes. Acta. Neuropathol. 82 (1991) 239-259
-
(1991)
Acta. Neuropathol.
, vol.82
, pp. 239-259
-
-
Braak, H.1
Braak, E.2
-
3
-
-
0037066084
-
Endoproteolysis of presenilin in vitro: inhibition by gamma-secretase inhibitors
-
Campbell W.A., Iskandar M.K., Reed M.L., and Xia W. Endoproteolysis of presenilin in vitro: inhibition by gamma-secretase inhibitors. Biochemistry 41 (2002) 3372-3379
-
(2002)
Biochemistry
, vol.41
, pp. 3372-3379
-
-
Campbell, W.A.1
Iskandar, M.K.2
Reed, M.L.3
Xia, W.4
-
4
-
-
0031897917
-
Functional analysis of the Huntington's disease (HD) gene promoter
-
Coles R., Caswell R., and Rubinsztein D.C. Functional analysis of the Huntington's disease (HD) gene promoter. Hum. Mol. Genet. 7 (1998) 791-800
-
(1998)
Hum. Mol. Genet.
, vol.7
, pp. 791-800
-
-
Coles, R.1
Caswell, R.2
Rubinsztein, D.C.3
-
5
-
-
0037431082
-
Aph-1, Pen-2, and nicastrin with presenilin generate an active gamma-secretase complex
-
De Strooper B. Aph-1, Pen-2, and nicastrin with presenilin generate an active gamma-secretase complex. Neuron 38 (2003) 9-12
-
(2003)
Neuron
, vol.38
, pp. 9-12
-
-
De Strooper, B.1
-
6
-
-
18444417998
-
Aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation
-
Francis R., McGrath G., Zhang J., Ruddy D.A., Sym M., Apfeld J., Nicoll M., Maxwell M., Hai B., Ellis M.C., Parks A.L., Xu W., Li J., Gurney M., Myers R.L., Himes C.S., Hiebsch R., Ruble C., Nye J.S., and Curtis D. Aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation. Dev. Cell 3 (2002) 85-97
-
(2002)
Dev. Cell
, vol.3
, pp. 85-97
-
-
Francis, R.1
McGrath, G.2
Zhang, J.3
Ruddy, D.A.4
Sym, M.5
Apfeld, J.6
Nicoll, M.7
Maxwell, M.8
Hai, B.9
Ellis, M.C.10
Parks, A.L.11
Xu, W.12
Li, J.13
Gurney, M.14
Myers, R.L.15
Himes, C.S.16
Hiebsch, R.17
Ruble, C.18
Nye, J.S.19
Curtis, D.20
more..
-
7
-
-
0037154158
-
APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos
-
Goutte C., Tsunozaki M., Hale V.A., and Priess J.R. APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos. Proc. Natl. Acad. Sci. U.S.A. 99 (2002) 775-779
-
(2002)
Proc. Natl. Acad. Sci. U.S.A.
, vol.99
, pp. 775-779
-
-
Goutte, C.1
Tsunozaki, M.2
Hale, V.A.3
Priess, J.R.4
-
8
-
-
0038360879
-
Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex
-
Hu Y., and Fortini M.E. Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex. J. Cell. Biol. 161 (2003) 685-690
-
(2003)
J. Cell. Biol.
, vol.161
, pp. 685-690
-
-
Hu, Y.1
Fortini, M.E.2
-
9
-
-
2942604376
-
The gamma-secretase complex: machinery for intramembrane proteolysis
-
Iwatsubo T. The gamma-secretase complex: machinery for intramembrane proteolysis. Curr. Opin. Neurobiol. 14 (2004) 379-383
-
(2004)
Curr. Opin. Neurobiol.
, vol.14
, pp. 379-383
-
-
Iwatsubo, T.1
-
10
-
-
0038652102
-
Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2
-
Kimberly W.T., LaVoie M.J., Ostaszewski B.L., Ye W.M., Wolfe S., and Selkoe D.J. Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2. Proc. Natl. Acad. Sci. U.S.A. 100 (2003) 6382-6387
-
(2003)
Proc. Natl. Acad. Sci. U.S.A.
, vol.100
, pp. 6382-6387
-
-
Kimberly, W.T.1
LaVoie, M.J.2
Ostaszewski, B.L.3
Ye, W.M.4
Wolfe, S.5
Selkoe, D.J.6
-
11
-
-
0034984156
-
The -48 C/T polymorphism in the presenilin 1 promoter is associated with an increased risk of developing Alzheimer's disease and an increased Abeta load in brain
-
Lambert J.C., Mann D.M., Harris J.M., Chartier-Harlin M.C., Cumming A., Coates J., Lemmon H., StClair D., Iwatsubo T., and Lendon C. The -48 C/T polymorphism in the presenilin 1 promoter is associated with an increased risk of developing Alzheimer's disease and an increased Abeta load in brain. J. Med. Genet. 38 (2001) 353-355
-
(2001)
J. Med. Genet.
, vol.38
, pp. 353-355
-
-
Lambert, J.C.1
Mann, D.M.2
Harris, J.M.3
Chartier-Harlin, M.C.4
Cumming, A.5
Coates, J.6
Lemmon, H.7
StClair, D.8
Iwatsubo, T.9
Lendon, C.10
-
12
-
-
0037424275
-
PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1
-
Luo W.J., Wang H., Li H., Kim B.S., Shah S., Lee H.J., Thinakaran G., Kim T.W., Yu G., and Xu H. PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1. J. Biol. Chem. 278 (2003) 7850-7854
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 7850-7854
-
-
Luo, W.J.1
Wang, H.2
Li, H.3
Kim, B.S.4
Shah, S.5
Lee, H.J.6
Thinakaran, G.7
Kim, T.W.8
Yu, G.9
Xu, H.10
-
13
-
-
37549040895
-
Promoter polymorphisms which modulate APP expression may increase susceptibility to Alzheimer's disease
-
Lv H., Jia L., and Jia J. Promoter polymorphisms which modulate APP expression may increase susceptibility to Alzheimer's disease. Neurobiol. Aging 29 (2008) 194-202
-
(2008)
Neurobiol. Aging
, vol.29
, pp. 194-202
-
-
Lv, H.1
Jia, L.2
Jia, J.3
-
14
-
-
12144250683
-
APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development
-
Ma G., Li T., Price D.L., and Wong P.C. APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development. J. Neurosci. 25 (2005) 192-198
-
(2005)
J. Neurosci.
, vol.25
, pp. 192-198
-
-
Ma, G.1
Li, T.2
Price, D.L.3
Wong, P.C.4
-
15
-
-
16844364135
-
Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions
-
Niimura M., Isoo N., Takasugi N., Tsuruoka M., Ui-Tei K., Saigo K., Morohashi Y., Tomita T., and Iwatsubo T. Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions. J. Biol. Chem. 280 (2005) 12967-12975
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 12967-12975
-
-
Niimura, M.1
Isoo, N.2
Takasugi, N.3
Tsuruoka, M.4
Ui-Tei, K.5
Saigo, K.6
Morohashi, Y.7
Tomita, T.8
Iwatsubo, T.9
-
16
-
-
0042827346
-
Association analysis between anterior-pharynx defective-1 genes polymorphisms and Alzheimer's disease
-
Poli M., Gatta L.B., Archetti S., Padovani A., Albertini A., and Finazzi D. Association analysis between anterior-pharynx defective-1 genes polymorphisms and Alzheimer's disease. Neurosci. Lett. 350 (2003) 77-80
-
(2003)
Neurosci. Lett.
, vol.350
, pp. 77-80
-
-
Poli, M.1
Gatta, L.B.2
Archetti, S.3
Padovani, A.4
Albertini, A.5
Finazzi, D.6
-
17
-
-
0035066332
-
Alzheimer's disease: genes, proteins, and therapy
-
Selkoe D.J. Alzheimer's disease: genes, proteins, and therapy. Physiol. Rev. 81 (2001) 741-766
-
(2001)
Physiol. Rev.
, vol.81
, pp. 741-766
-
-
Selkoe, D.J.1
-
18
-
-
13444268952
-
Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo
-
Serneels L., Dejaegere T., Craessaerts K., Horre K., Jorissen E., Tousseyn T., Hebert S., Coolen M., Martens G., Zwijsen A., Annaert W., Hartmann D., and De Strooper B. Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo. Proc. Natl. Acad. Sci. U.S.A. 102 (2005) 1719-1724
-
(2005)
Proc. Natl. Acad. Sci. U.S.A.
, vol.102
, pp. 1719-1724
-
-
Serneels, L.1
Dejaegere, T.2
Craessaerts, K.3
Horre, K.4
Jorissen, E.5
Tousseyn, T.6
Hebert, S.7
Coolen, M.8
Martens, G.9
Zwijsen, A.10
Annaert, W.11
Hartmann, D.12
De Strooper, B.13
-
19
-
-
0028218871
-
Neuropathological changes in Alzheimer disease
-
Terry R.D. Neuropathological changes in Alzheimer disease. Prog. Brain Res. 101 (1994) 383-390
-
(1994)
Prog. Brain Res.
, vol.101
, pp. 383-390
-
-
Terry, R.D.1
-
20
-
-
0002722479
-
Linkage disequilibrium between alleles at marker loci
-
The John Hopkins University Press, Baltimore, MD pp. 188-198
-
Terwilliger J.D., and Ott J. Linkage disequilibrium between alleles at marker loci. Handbook of Human Genetic Linkage (1994), The John Hopkins University Press, Baltimore, MD pp. 188-198
-
(1994)
Handbook of Human Genetic Linkage
-
-
Terwilliger, J.D.1
Ott, J.2
-
21
-
-
0028301820
-
Apolipoprotein E: risk factor for Alzheimer disease
-
Tsai M.S., Tangalos E.G., Petersen R.C., Smith G.E., Schaid D.J., Kokmen E., Ivnik R.J., and Thibodeau S.N. Apolipoprotein E: risk factor for Alzheimer disease. Am. J. Hum. Genet. 54 (1994) 643-649
-
(1994)
Am. J. Hum. Genet.
, vol.54
, pp. 643-649
-
-
Tsai, M.S.1
Tangalos, E.G.2
Petersen, R.C.3
Smith, G.E.4
Schaid, D.J.5
Kokmen, E.6
Ivnik, R.J.7
Thibodeau, S.N.8
-
22
-
-
33748945560
-
Alpha-synuclein promoter RsaI T-to-C polymorphism and the risk of Parkinson's disease
-
Wang C.K., Chen C.M., Chang C.Y., Chang K.H., Chen I.C., Li M.L., Lee-Chen G.J., and Wu Y.R. Alpha-synuclein promoter RsaI T-to-C polymorphism and the risk of Parkinson's disease. J. Neural. Transm. 113 (2006) 1425-1433
-
(2006)
J. Neural. Transm.
, vol.113
, pp. 1425-1433
-
-
Wang, C.K.1
Chen, C.M.2
Chang, C.Y.3
Chang, K.H.4
Chen, I.C.5
Li, M.L.6
Lee-Chen, G.J.7
Wu, Y.R.8
|