Genetic variations of solute carrier family 30 (zinc transporter) member 8 (SLC30A8) are not associated with polycystic ovary syndrome

Fertility and Sterility

Volumn 91, Issue 4 SUPPL., 2009, Pages 1598-1601

  Li, Li ^a   Zhao, Yueran ^a   Wang, Laicheng ^a   Yan, Junhao ^a   Chen, Zi jiang ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

insulin secretion; Polycystic ovary syndrome; single nucleotide polymorphism; SLC30A8; type 2 diabetes mellitus

Indexed keywords

ALLELE; ARTICLE; BODY MASS; CLINICAL FEATURE; CONTROLLED STUDY; FEMALE; GENE; GENE FREQUENCY; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SLC30A8 GENE;

CASE-CONTROL STUDIES; CATION TRANSPORT PROTEINS; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; POLYCYSTIC OVARY SYNDROME; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 63549124376     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2008.11.004     Document Type: Article

References (15)

1. Franks S. Polycystic ovary syndrome. N Engl J Med 333 (1995) 853-861
2. Sladek R., Rocheleau G., Rung J., Dina C., Shen L., Serre D., et al. A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 445 (2007) 881-885
3. Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod 19 (2004) 41-47
4. Staiger H., Machicao F., Stefan N., Tschritter O., Thamer C., Kantartzis K., et al. Polymorphisms within novel risk loci for type 2 diabetes determine beta-cell function. PLoS ONE 2 (2007) e832
5. Papp A.C., Pinsonneault J.K., Cooke G., and Sadée W. Single nucleotide polymorphism genotyping using allele-specific PCR and fluorescence melting curves. Biotechniques 34 (2003) 1068-1072
6. Wang J., Chuang K., Ahluwalia M., Patel S., Umblas N., Mirel D., et al. High-throughput SNP genotyping by single-tube PCR with Tm-shift primers. Biotechniques 39 (2005) 885-893
7. Raymond M., and Rousset F. GENEPOP (version 1.2): population genetics software for exact tests and ecumenicism. J Heredity 86 (1995) 248-249
8. Chimienti F., Favier A., and Seve M. ZnT-8, a pancreatic beta-cell-specific zinc transporter. Biometals 18 (2005) 313-317
9. Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical Research, Saxena R., Voight B.F., Lyssenko V., Burtt N.P., de Bakker P.I., et al. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 316 (2007) 1331-1336
10. Zeggini E., Weedon M.N., Lindgren C.M., Frayling T.M., Elliott K.S., Lango H., et al. Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 316 (2007) 1336-1341
11. Scott L.J., Mohlke K.L., Bonnycastle L.L., Willer C.J., Li Y., Duren W.L., et al. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 316 (2007) 1341-1345
12. Xiang J., Li X.Y., Xu M., Hong J., Huang Y., Tan J.R., et al. Zinc transporter-8 gene (SLC30A8) is associated with type 2 diabetes in Chinese. J Clin Endocrinol Metab 93 (2008) 4107-4112
13. Lee E.J., Yoo K.J., Kim S.J., Lee S.H., Cha K.Y., and Baek K.H. Single nucleotide polymorphism in exon 17 of the insulin receptor gene is not associated with polycystic ovary syndrome in a Korean population. Fertil Steril 86 (2006) 380-384
14. Antoine H.J., Pall M., Trader B.C., Chen Y.D., Azziz R., and Goodarzi M.O. Genetic variants in peroxisome proliferator-activated receptor gamma influence insulin resistance and testosterone levels in normal women, but not those with polycystic ovary syndrome. Fertil Steril 87 (2007) 862-869
15. Barber T.M., Bennett A.J., Groves C.J., Sovio U., Ruokonen A., Martikainen H., et al. Disparate genetic influences on polycystic ovary syndrome (PCOS) and type 2 diabetes revealed by a lack of association between common variants within the TCF7L2 gene and PCOS. Diabetologia 50 (2007) 2318-2322