Gene Expression of Human Beta-defensins in Healthy and Inflamed Human Dental Pulps

Journal of Endodontics

Volumn 35, Issue 4, 2009, Pages 520-523

  Paris, Sebastian ^a,b   Wolgin, Michael ^a   Kielbassa, Andrej Michael ^a   Pries, Axel ^a   Zakrzewicz, Andreas ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY OF KIEL   (Germany)

Author keywords

Dental pulp; hBD; human beta defensins; inflammation; pulpitis

Indexed keywords

BETA DEFENSIN;

ARTICLE; BIOSYNTHESIS; GENE EXPRESSION; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; MUCOSAL IMMUNITY; PHYSIOLOGY; PULPITIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TOOTH PULP; UPREGULATION;

BETA-DEFENSINS; DENTAL PULP; GENE EXPRESSION; HUMANS; IMMUNITY, MUCOSAL; PULPITIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; UP-REGULATION;

EID: 63449139717     PISSN: 00992399     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.joen.2008.12.015     Document Type: Article

References (35)

1. Smith A.J. Formation and repair. In: Hargreaves K.M., and Goodis H.E. (Eds). Setzer and Bender's dental pulp. 1st ed (2002), Quintessence, Berlin 41-63
2. Dale B.A., and Krisanaprakornkit S. Defensin antimicrobial peptides in the oral cavity. J Oral Pathol Med 30 (2001) 321-327
3. Schroder J.M. Epithelial peptide antibiotics. Biochem Pharmacol 57 (1999) 121-134
4. Dommisch H., Winter J., Acil Y., Dunsche A., Tiemann M., and Jepsen S. Human beta-defensin (hBD-1, -2) expression in dental pulp. Oral Microbiol Immunol 20 (2005) 163-166
5. Dommisch H., Winter J., Willebrand C., Eberhard J., and Jepsen S. Immune regulatory functions of human beta-defensin-2 in odontoblast-like cells. Int Endod J 40 (2007) 300-307
6. Veerayutthwilai O., Byers M.R., Pham T.T., Darveau R.P., and Dale B.A. Differential regulation of immune responses by odontoblasts. Oral Microbiol Immunol 22 (2007) 5-13
7. Boman H.G. Peptide antibiotics and their role in innate immunity. Annu Rev Immunol 13 (1995) 61-92
8. Nicolas P., and Mor A. Peptides as weapons against microorganisms in the chemical defense system of vertebrates. Annu Rev Microbiol 49 (1995) 277-304
9. Garcia J.R., Krause A., Schulz S., et al. Human beta-defensin 4: a novel inducible peptide with a specific salt-sensitive spectrum of antimicrobial activity. Faseb J 15 (2001) 1819-1821
10. Joly S., Maze C., McCray Jr. P.B., and Guthmiller J.M. Human beta-defensins 2 and 3 demonstrate strain-selective activity against oral microorganisms. J Clin Microbiol 42 (2004) 1024-1029
11. Feng Z., Jiang B., Chandra J., Ghannoum M., Nelson S., and Weinberg A. Human beta-defensins: differential activity against candidal species and regulation by Candida albicans. J Dent Res 84 (2005) 445-450
12. Hazrati E., Galen B., Lu W., et al. Human alpha- and beta-defensins block multiple steps in herpes simplex virus infection. J Immunol 177 (2006) 8658-8666
13. Quinones-Mateu M.E., Lederman M.M., Feng Z., et al. Human epithelial beta-defensins 2 and 3 inhibit HIV-1 replication. AIDS 17 (2003) F39-F48
14. Sun L., Finnegan C.M., Kish-Catalone T., et al. Human beta-defensins suppress human immunodeficiency virus infection: potential role in mucosal protection. J Virol 79 (2005) 14318-14329
15. Chen X., Niyonsaba F., Ushio H., et al. Antimicrobial peptides human beta-defensin (hBD)-3 and hBD-4 activate mast cells and increase skin vascular permeability. Eur J Immunol 37 (2007) 434-444
16. Marshall R.I. Gingival defensins: linking the innate and adaptive immune responses to dental plaque. Periodontol 2004 35 (2000) 14-20
17. Schneider J.J., Unholzer A., Schaller M., Schafer-Korting M., and Korting H.C. Human defensins. J Mol Med 83 (2005) 587-595
18. Shiba H., Mouri Y., Komatsuzawa H., et al. Macrophage inflammatory protein-3alpha and beta-defensin-2 stimulate dentin sialophosphoprotein gene expression in human pulp cells. Biochem Biophys Res Commun 306 (2003) 867-871
19. Feucht E.C., DeSanti C.L., and Weinberg A. Selective induction of human beta-defensin mRNAs by Actinobacillus actinomycetemcomitans in primary and immortalized oral epithelial cells. Oral Microbiol Immunol 18 (2003) 359-363
20. Krisanaprakornkit S., Kimball J.R., Weinberg A., Darveau R.P., Bainbridge B.W., and Dale B.A. Inducible expression of human beta-defensin 2 by Fusobacterium nucleatum in oral epithelial cells: multiple signaling pathways and role of commensal bacteria in innate immunity and the epithelial barrier. Infect Immun 68 (2000) 2907-2915
21. Central-German-Ethics-Committee Statement: the use of human body materials for purposes of medical research. Available at: http://www.zentrale-ethikkommission.de/page.asp?his=0.1.21. Accessed September 10, 2008.
22. AAE. Glossary of endodontic terms (2007), American Association of Endodontists, Chicago
23. Bender I.B. Reversible and irreversible painful pulpitides: diagnosis and treatment. Aust Endod J 26 (2000) 10-14
24. Bongrazio M., Da Silva-Azevedo L., Bergmann E.C., et al. Shear stress modulates the expression of thrombospondin-1 and CD36 in endothelial cells in vitro and during shear stress-induced angiogenesis in vivo. Int J Immunopathol Pharmacol 19 (2006) 35-48
25. Sambrook J., Fritsch E.F., and Maniatis T. Extraction, purification, and analysis of messenger RNA from eukaryotic cells. In: Ford N., Nolan C., and Ferguson M. (Eds). Molecular cloning: a laboratory manual (1989), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY 7.3-7.87
26. Dommisch H, Winter J, Hacker J, et al. Differential gene expression of cytokines and beta-defensins in dental pulp. Adv Dent Res (in press).
27. Bajaj-Elliott M., Fedeli P., Smith G.V., et al. Modulation of host antimicrobial peptide (beta-defensins 1 and 2) expression during gastritis. Gut 51 (2002) 356-361
28. Sahasrabudhe K.S., Kimball J.R., Morton T.H., Weinberg A., and Dale B.A. Expression of the antimicrobial peptide, human beta-defensin 1, in duct cells of minor salivary glands and detection in saliva. J Dent Res 79 (2000) 1669-1674
29. Wehkamp J., Harder J., Weichenthal M., et al. Inducible and constitutive beta-defensins are differentially expressed in Crohn's disease and ulcerative colitis. Inflamm Bowel Dis 9 (2003) 215-223
30. Seo S.J., Ahn S.W., Hong C.K., and Ro B.I. Expressions of beta-defensins in human keratinocyte cell lines. J Dermatol Sci 27 (2001) 183-191
31. Sherman H., Chapnik N., and Froy O. Albumin and amino acids upregulate the expression of human beta-defensin 1. Mol Immunol 43 (2006) 1617-1623
32. Duits L.A., Ravensbergen B., Rademaker M., Hiemstra P.S., and Nibbering P.H. Expression of beta-defensin 1 and 2 mRNA by human monocytes, macrophages and dendritic cells. Immunology 106 (2002) 517-525
33. van Wetering S., Sterk P.J., Rabe K.F., and Hiemstra P.S. Defensins: key players or bystanders in infection, injury, and repair in the lung?. J Allergy Clin Immunol 104 (1999) 1131-1138
34. Kokkas A.B., Goulas A., Varsamidis K., Mirtsou V., and Tziafas D. Irreversible but not reversible pulpitis is associated with up-regulation of tumour necrosis factor-alpha gene expression in human pulp. Int Endod J 40 (2007) 198-203
35. Martinez Z.R., Naruishi K., Yamashiro K., et al. Gene profiles during root canal treatment in experimental rat periapical lesions. J Endod 33 (2007) 936-943