Immune regulatory functions of human beta-defensin-2 in odontoblast-like cells

International Endodontic Journal

Volumn 40, Issue 4, 2007, Pages 300-307

  Dommisch, H ^a,b   Winter, J ^a   Willebrand, C ^a   Eberhard, J ^c   Jepsen, S ^a  

^a UNIVERSITY HOSPITAL BONN   (Germany)

^b UNIVERSITY OF WASHINGTON   (United States)

^c UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

Cytosolic phospholipase A 2; Human beta defensins; Innate immunity; Interleukins; Odontoblast like cells; Real time PCR

Indexed keywords

BETA DEFENSIN; COMPLEMENTARY DNA; DEFB1 PROTEIN, HUMAN; DEFB4 PROTEIN, HUMAN; GROUP IV PHOSPHOLIPASES A2; INTERLEUKIN 6; INTERLEUKIN 8; PHOSPHOLIPASE A; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ADULT; ANALYSIS OF VARIANCE; ARTICLE; BIOSYNTHESIS; CELL CULTURE; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; HUMAN; IMMUNOLOGY; INNATE IMMUNITY; ODONTOBLAST; POLYMERASE CHAIN REACTION; TOOTH PULP;

ADULT; ANALYSIS OF VARIANCE; BETA-DEFENSINS; CELLS, CULTURED; DENTAL PULP; DNA, COMPLEMENTARY; GENE EXPRESSION REGULATION; HUMANS; IMMUNITY, NATURAL; INTERLEUKIN-6; INTERLEUKIN-8; ODONTOBLASTS; PHOSPHOLIPASES A; POLYMERASE CHAIN REACTION; RECOMBINANT PROTEINS;

EID: 33947398003     PISSN: 01432885     EISSN: 13652591     Source Type: Journal    
DOI: 10.1111/j.0143-2885.2007.01228.x     Document Type: Article

References (38)

1. Akira S, Hirano T, Taga T, Kishimoto T (1990) Biology of multifunctional cytokincs: IL 6 and related molecules (IL 1 and TNF). Journal of the Federation of American Societies for Experimental Biology 4, 2860-7.
2. Bensch KW, Raida M. Magert HJ, Schulz-Knappe P, Forssmann WG (1995) hBD-1: a novel beta-defensin from human plasma. Letters to Journal of the Federation of European Biochemical Societies 368, 331-5.
3. Boyce JA (2005) Eicosanoid mediators of mast cells: receptors, regulation of synthesis, and pathohiologic implications. Chemical Immunology and Allergy 87, 59-79.
4. Brogden KA (2005) Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? Nature Reviews. Microbiology 3, 238-50.
5. Chadebech P, Goidin D, Jacquet C, Viac J, Schmitt D, Staquet MJ (2005) Use of human reconstructed epidermis to analyze the regulation of beta-defensin hBD-1. hBD-2, and hBD-3 expression in response to LPS. Cell Biology and Toxicology 19, 313-24.
6. Dale BA, Krisanaprakornkit S (2001) Defensin antimicrobial peptides in the oral cavity. Journal of Oral Pathology and Medicine 30, 321-7.
7. Dommisch H, Acil Y, Dunsehe A, Winter J, Jepsen S (2005a) Differential gene expression of human beta-defensins (hBD-1, -2, -3) in inflammatory gingival diseases. Oral Microbiology and Immunology 20. 186-90.
8. Dommisch H, Winter J, Acil Y, Dunsche A, Tiemann M, Jepsen S (2005b) Human beta-defensin (hBD-1. -2) expression in dental pulp. Oral Microbiology and Immunology 20, 163-6.
9. Dommisch H, Winter J, Hacker J et al. (2007) Differential gene expression of cytokines and human beta-defensins in dental pulp. Advances in Dental Research, accepted for publication.
10. Donkersloot JA, Hoerman KC (1974) Letter: S. mutans and caries. Journal of the American Dental Association 88, 466-7.
11. Duits LA, Ravensbergen B, Rademaker M, Hiemstra PS. Nibbering PH (2002) Expression of beta-defensin 1 and 2 mRNA by human monocytes, macrophages and dendritic cells. Immunology 106, 517-25.
12. Dunsche A, Acil Y, Sichert R, Harder J, Sehroder JM. Jepsen S (2001) Expression profile of human defensins and antimicrobial proteins in oral tissues, Journal of Oral Pathology and Medicine 30. 154-8.
13. Dunsche A, Acil Y, Dommisch H, Siebert R, Schroder JM, Jepsen S (2002) The novel human beta-defensin-3 is widely expressed in oral tissues. European Journal of Oral Sciences 110, 121-4.
14. Engels-Deutsch M, Pini A, Yamashita Y et al. (2003) Insertional in activation of pac and rmlB genes reduces the release of tumor necrosis factor alpha, interleukin-6, and interleukin-8 induced by Streptococcus mutans in monocytic, dental pulp, and periodontal ligament cells. Infection and Immunity 71, 5169-77.
15. Ganz T (2003) Defensins: antimicrobial peptides of innate immunity. Nature Reviews, Immunology 3, 710-20.
16. Hahn CL, Best AM, Tew JG (2000) Cytokinc induction by Streptoroccus mutans and pulpal palhogenesis. infection and Immunity 68, 6785-9.
17. Harder J, Bartels J, Christophers E, Schroder JM (1997) A peptide antibiotic from human skin. Nature 387, 861.
18. Harder J, Bartels J, Christophers E, Schroder JM (2001) Isolation and characterization of human beta-defensin-.3, a novel human induciblc peptide antibiotic. The Journal of Biological Chemistry 276, 5707-13.
19. Islam D, Bandholte L, Nilsson J et al. (2001) Downregulation of bactericidal peptides in enteric infections: a novel immune escape mechanism with bacterial DNA as a potential regulator. Nature Medicine 7, 180-5.
20. Izumi T, Kobayashi I, Okamura K, Sakai H (1995) Immunohistochemical study on the immunocompetent cells of the pulp in human non-carious and carious teeth. Archives of Oral Biology 40, 609-14.
21. Jontell M, Okiji T, Dahlgren U, Bergenholtz G (1998) Immune defense mechanisms of the dental pulp. Critical Reviews in Oral Biology and Medicine 9, 179-200.
22. Krisanaprakornkit S, Weinberg A, ferez CN. Dale BA (1998) Expression of the peptide antibiotic human beta-defensin 1 in cultured gingival epithelial cells and gingival tissue. Infection and Immunity 66, 4222-8.
23. Krisanaprakornkit S, Kimball JR. Weinberg A, Darveau RP, Bainbridge BW, Dale BA (2000) Induciblc expression of human beta-defensin 2 by Eusobacterium nucleatum in oral epithelial cells: multiple signaling pathways and role of commensal bacteria in innate immunity and the epithelial barrier. Infection and Immunity 68, 2907-15.
24. Lehrer RI (2004) Primate defensins. Nature Review's. Microbiology 2, 727-38.
25. Nishimura E, Eto A, Kato M et al. (2004) Oral streptococci exhibit diverse susceptibility to human beta-defensin-2: antimicrobial effects of hBD-2 on oral streptococci. Current Microbiology 48, 85-7.
26. Niyonsaba F, Someya A, Hirata M, Ogawa H, Nagaoka I (2001) Evaluation of the effects of peptide antibiotics human beta-defensins-1/-2 and LL-37 on histaminc release and prostaglandin D(2) production from mast cells. European Journal of Immunology 31, 1066-75.
27. Niyonsaba F, Iwabuchi K, Matsuda H, Ogawa H, Nagaoka I (2002) Epithelial cell-derived human beta-defensin-2 acts as a chemotaxin for mast cells through a pertussis toxinsensitive and phospholipase C-dependcnt pathway. International Immunology 14. 421-6.
28. Niyonsaba F, Ogawa H, Nagaoka I (2004) Human beta-defensin-2 functions as a chemotactic agent for tumour necrosis factor-alpha-treated human neutrophils. Immunology 111, 273-81.
29. Pfaffl MW (2001) A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Research 29, e45.
30. Sahasrabudhe KS. Kimball JR. Morton TH, Weinberg A, Dale BA (2000) Expression of the antimicrobial peptide, human beta-defensin 1, in duct cells of minor salivary glands and detection in saliva. Journal of Dental Research 79, 1669-74.
31. Sakamoto N, Mukae H, Fuiii T et al. (2005) Differential effects of alpha- and beta-defensin on cytokine production by cultured human bronchial epithelial cells. American Journal of Physiology. Lung Cellular and Molecular Physiology 288, L508-13.
32. Schroder JM (1999) Epithelial peptide antibiotics. Biochemical Pharmacology 57, 121-34.
33. Schroder JM. Christophers E (1992) The biology of NAP-1/IL-8, a neutrophil-activating cytokinc. Immunology Series 57, 387-116.
34. Shiba H, Mouri Y, Komatsuzawa H et al. (2003) Macrophage inflammatory protein-3alpha and heta-defensin-2 stimulate dentin sialophosphoprotein gene expression in human pulp cells. Biochemical and Biophysical Research Communications 306, 867-71.
35. Takahashi A, Wada A, Ogushi K et al. (2001) Production of heta-defensin-2 by human colonie epithelial cells induced by Salmonella enteritidis flagella filament structural protein. Letters to Journal of the Federation of European Biochemical Societies 508, 484-8.
36. Tjaderhane L, Salo T, Larjava H, Larmas M, Overall CM (1998) A novel organ culture method to study the function of human odontoblasts in vitro: gelatinase expression by odontohlasts is differentially regulated by TCP-beta 1. Journal of Dental Research 77, 1486-96.
37. Yang D, Biragyn A, Kwak LW, Oppenheim JJ (2002) Mammalian defensins in immunity: more than Just microbicidal. Trends in Immunology 23, 291-6.
38. Zhao C, Wang I, Lehrer RI (1996) Widespread expression of beta-defensin hBD-1 in human secretory glands and epithelial cells. letters to Journal of the Federation of European Biochemical Societies 396, 319-22.