A standardized procedure for using human corpus cavernosum strips to evaluate drug activity

Journal of Pharmacological and Toxicological Methods

Volumn 44, Issue 3, 2000, Pages 477-482

  Mirone, Vincenzo ^a   Sorrentino, Raffaella ^a   Di Villa Bianca, Roberta d'Emmanuele ^a   Imbimbo, Ciro ^a   Palmieri, Alessandro ^a   Fusco, Ferdinando ^a   Tajana, Gianfranco ^a   Cirino, Giuseppe ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Alprostadil; Bioassay; Cromakalim; Gender reassignment; Human corpus cavernosum

Indexed keywords

ACETYLCHOLINE; ANGIOTENSIN; CROMAKALIM; NITROPRUSSIDE SODIUM; PHENYLEPHRINE; POTASSIUM CHLORIDE; PROSTAGLANDIN E1;

ARTICLE; BIOASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORPUS CAVERNOSUM; DRUG ACTIVITY; DRUG EFFECT; ETHICS; FREEZING; GENDER; HUMAN; HUMAN TISSUE; MALE; PATHOPHYSIOLOGY; PENIS AMPUTATION; REGULATORY MECHANISM; STANDARDIZATION; TISSUE REACTION;

ACETYLCHOLINE; ALPROSTADIL; ANGIOTENSIN II; BIOLOGICAL ASSAY; CROMAKALIM; HUMANS; MALE; MUSCLE CONTRACTION; MUSCLE RELAXATION; MUSCLE, SMOOTH; NITROPRUSSIDE; PENIS; PHENYLEPHRINE; POTASSIUM CHLORIDE; TRANSSEXUALISM;

EID: 0034440240     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1056-8719(00)00114-3     Document Type: Article

References (10)

1. Evidence for the involvement of endothelial nitric oxide synthase from smooth muscle cells in the erectile function of the human corpus cavernosum
2. Immunohistochemical localization of nitric oxide synthase in the autonomic innervation of the human penis
3. An analysis of the maxi-K channel in cultured human corporal smooth muscle cells
4. Possible role of Na-K-ATPase in the regulation of human corpus cavernosum smooth muscle contractility by nitric oxide
5. Erectile dysfunction in aging: Upregulation of endothelial nitric oxide synthase
6. Effects of nicorandil on human isolated corpus cavernosum and cavernous artery
7. Nitric oxide mediates neurogenic relaxation induced in rabbit cavernous smooth muscle by electric field stimulation
8. Experience with the 1-stage surgical approach for constructing female genitalia in male transsexual
9. Contribution of K channels and ouabain-sensitive mechanisms to the endothelium-dependent relaxations of horse penile small arteries
10. Ex vivo expression of nitric oxide synthase isoforms (eNOS/iNOS) and calmodulinin human penile cavernosal cells