Renal elimination of organic anions in cholestasis

World Journal of Gastroenterology

Volumn 14, Issue 43, 2008, Pages 6616-6621

  Torres, Adriana Mónica ^a  

^a UNIVERSIDAD NACIONAL DE ROSARIO   (Argentina)

Author keywords

Extrahepatic cholestasis; Furosemide; OAT1; OAT3; Organic anions; P aminohippurate

Indexed keywords

ANION; FAMOTIDINE; FUROSEMIDE; METHOTREXATE; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 3; RANITIDINE;

4 AMINOHIPPURIC ACID CLEARANCE; CHOLESTASIS; DRUG ELIMINATION; DRUG TRANSPORT; EDITORIAL; EXTRAHEPATIC BILE DUCT OBSTRUCTION; HUMAN; KIDNEY FUNCTION TEST; KIDNEY INJURY; KIDNEY PROXIMAL TUBULE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REGULATORY MECHANISM; RISK FACTOR; URINARY EXCRETION;

EID: 63449108001     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.14.6616     Document Type: Editorial

References (52)

1. Shitara Y, Horie T, Sugiyama Y. Transporters as a determinant of drug clearance and tissue distribution. Eur J Pharm Sci 2006; 27: 425-446
2. Sweet DH. Organic anion transporter (Slc22a) family members as mediators of toxicity. Toxicol Appl Pharmacol 2005; 204: 198-215
3. Wright SH, Dantzler WH. Molecular and cellular physiology of renal organic cation and anion transport. Physiol Rev 2004; 84: 987-1049
4. Anzai N, Kanai Y, Endou H. Organic anion transporter family: current knowledge. J Pharmacol Sci 2006; 100: 411-426
5. Rizwan AN, Burckhardt G. Organic anion transporters of the SLC22 family: biopharmaceutical, physiological, and pathological roles. Pharm Res 2007; 24: 450-470
6. Monica Torres A, Mac Laughlin M, Muller A, Brandoni A, Anzai N, Endou H. Altered renal elimination of organic anions in rats with chronic renal failure. Biochim Biophys Acta 2005; 1740: 29-37
7. Di Giusto G, Anzai N, Endou H, Torres AM. Elimination of organic anions in response to an early stage of renal ischemia-reperfusion in the rat: role of basolateral plasma membrane transporters and cortical renal blood flow. Pharmacology 2008; 81: 127-136
8. Villar SR, Brandoni A, Quaglia NB, Torres AM. Renal elimination of organic anions in rats with bilateral ureteral obstruction. Biochim Biophys Acta 2004; 1688: 204-209
9. Villar SR, Brandoni A, Anzai N, Endou H, Torres AM. Altered expression of rat renal cortical OAT1 and OAT3 in response to bilateral ureteral obstruction. Kidney Int 2005; 68: 2704-2713
10. Qualglia NB, Hofer CG, Torres AM. Pharmacokinetics of organic anions in rats with arterial calcinosis. Clin Exp Pharmacol Physiol 2002; 29: 48-52
11. Quaglia NB, Brandoni A, Ferri A, Torres AM. Early manifestation of nephropathy in rats with arterial calcinosis. Ren Fail 2003; 25: 355-366
12. Brandoni A, Quaglia NB, Torres AM. Compensation increase in organic anion excretion in rats with acute biliary obstruction: role of the renal organic anion transporter 1. Pharmacology 2003; 68: 57-63
13. Brandoni A, Villar SR, Picena JC, Anzai N, Endou H, Torres AM. Expression of rat renal cortical OAT1 and OAT3 in response to acute biliary obstruction. Hepatology 2006; 43: 1092-1100
14. Brandoni A, Anzai N, Kanai Y, Endou H, Torres AM. Renal elimination of p-aminohippurate (PAH) in response to three days of biliary obstruction in the rat. The role of OAT1 and OAT3. Biochim Biophys Acta 2006; 1762: 673-682
15. Sekine T, Watanabe N, Hosoyamada M, Kanai Y, Endou H. Expression cloning and characterization of a novel multispecific organic anion transporter. J Biol Chem 1997; 272: 18526-18529
16. Sweet DH, Wolff NA, Pritchard JB. Expression cloning and characterization of ROAT1. The basolateral organic anion transporter in rat kidney. J Biol Chem 1997; 272: 30088-30095
17. Wolff NA, Werner A, Burkhardt S, Burckhardt G. Expression cloning and characterization of a renal organic anion transporter from winter flounder. FEBS Lett 1997; 417: 287-291
18. Kojima R, Sekine T, Kawachi M, Cha SH, Suzuki Y, Endou H. Immunolocalization of multispecific organic anion transporters, OAT1, OAT2, and OAT3, in rat kidney. J Am Soc Nephrol 2002; 13: 848-857
19. Eraly SA, Vallon V, Vaughn DA, Gangoiti JA, Richter K, Nagle M, Monte JC, Rieg T, Truong DM, Long JM, Barshop BA, Kaler G, Nigam SK. Decreased renal organic anion secretion and plasma accumulation of endogenous organic anions in OAT1 knock-out mice. J Biol Chem 2006; 281: 5072-5083
20. Cha SH, Sekine T, Fukushima JI, Kanai Y, Kobayashi Y, Goya T, Endou H. Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol Pharmacol 2001; 59: 1277-1286
21. Sweet DH, Chan LM, Walden R, Yang XP, Miller DS, Pritchard JB. Organic anion transporter 3 (Slc22a8) is a dicarboxylate exchanger indirectly coupled to the Na+ gradient. Am J Physiol Renal Physiol 2003; 284: F763-F769
22. Bakhiya A, Bahn A, Burckhardt G, Wolff N. Human organic anion transporter 3 (hOAT3) can operate as an exchanger and mediate secretory urate flux. Cell Physiol Biochem 2003; 13: 249-256
23. Sweet DH, Miller DS, Pritchard JB, Fujiwara Y, Beier DR, Nigam SK. Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 (Slc22a8)) knockout mice. J Biol Chem 2002; 277: 26934-26943
24. Fleck C, Braunlich H. Factors determining the relationship between renal and hepatic excretion of xenobiotics. Arzneimittelforschung 1990; 40: 942-946
25. Fleck C, Braunlich H. Renal handling of drugs and amino acids after impairment of kidney or liver function - influences of maturity and protective treatment. Pharmacol Ther 1995; 67: 53-77
26. Sugi K, Inoue M, Morino Y, Sato T. Effect of obstructive jaundice on the fate of a nephrophilic organic anion in the rat. Biochim Biophys Acta 1989; 987: 217-221
27. Kramer HJ. Impaired renal function in obstructive jaundice: roles of the thromboxane and endothelin systems. Nephron 1997; 77: 1-12
28. Bataller R, Sort P, Gines P, Arroyo V. Hepatorenal syndrome: definition, pathophysiology, clinical features and management. Kidney Int Suppl 1998; 66: S47-S53
29. Orellana M, Rodrigo R, Thielemann L, Guajardo V. Bile duct ligation and oxidative stress in the rat: effects in liver and kidney. Comp Biochem Physiol C Toxicol Pharmacol 2000; 126: 105-111
30. Holt S, Marley R, Fernando B, Harry D, Anand R, Goodier D, Moore K. Acute cholestasis-induced renal failure: effects of antioxidants and ligands for the thromboxane A2 receptor. Kidney Int 1999; 55: 271-277
31. Kramer HJ, Schwarting K, Backer A, Meyer-Lehnert H. Renal endothelin system in obstructive jaundice: its role in impaired renal function of bile-duct ligated rats. Clin Sci (Lond) 1997; 92: 579-585
32. Gonzalez-Correa JA, De La Cruz JP, Martin-Aurioles E, Lopez-Egea MA, Ortiz P, Sanchez de la Cuesta F. Effects of S-adenosyl-L-methionine on hepatic and renal oxidative stress in an experimental model of acute biliary obstruction in rats. Hepatology 1997; 26: 121-127
33. Koopen NR, Muller M, Vonk RJ, Zimniak P, Kuipers F. Molecular mechanisms of cholestasis: causes and consequences of impaired bile formation. Biochim Biophys Acta 1998; 1408: 1-17
34. Reichen J, Simon FR. Mechanisms of cholestasis. Int Rev Exp Pathol 1984; 26: 231-274
35. Talbert RL. Drug dosing in renal insufficiency. J Clin Pharmacol 1994; 34: 99-110
36. Levy M, Finestone H. Renal response to four hours of biliary obstruction in the dog. Am J Physiol 1983; 244: F516-F525
37. Plebani M, Panozzo MP, Basso D, De Paoli M, Biasin R, Infantolino D. Cytokines and the progression of liver damage in experimental bile duct ligation. Clin Exp Pharmacol Physiol 1999; 26: 358-363
38. Tanaka Y, Kobayashi Y, Gabazza EC, Higuchi K, Kamisako T, Kuroda M, Takeuchi K, Iwasa M, Kaito M, Adachi Y. Increased renal expression of bilirubin glucuronide transporters in a rat model of obstructive jaundice. Am J Physiol Gastrointest Liver Physiol 2002; 282: G656-G662
39. Villanueva SS, Ruiz ML, Soroka CJ, Cai SY, Luquita MG, Torres AM, Sanchez Pozzi EJ, Pellegrino JM, Boyer JL, Catania VA, Mottino AD. Hepatic and extrahepatic synthesis and disposition of dinitrophenyl-S-glutathione in bile duct-ligated rats. Drug Metab Dispos 2006; 34: 1301-1309
40. Lee J, Azzaroli F, Wang L, Soroka CJ, Gigliozzi A, Setchell KD, Kramer W, Boyer JL. Adaptive regulation of bile salt transporters in kidney and liver in obstructive cholestasis in the rat. Gastroenterology 2001; 121: 1473-1484
41. Smeets PH, van Aubel RA, Wouterse AC, van den Heuvel JJ, Russel FG. Contribution of multidrug resistance protein 2 (MRP2/ABCC2) to the renal excretion of p-aminohippurate (PAH) and identification of MRP4 (ABCC4) as a novel PAH transporter. J Am Soc Nephrol 2004; 15: 2828-2835
42. Denk GU, Soroka CJ, Takeyama Y, Chen WS, Schuetz JD, Boyer JL. Multidrug resistance-associated protein 4 is up-regulated in liver but down-regulated in kidney in obstructive cholestasis in the rat. J Hepatol 2004; 40: 585-591
43. Pei QL, Kobayashi Y, Tanaka Y, Taguchi Y, Higuchi K, Kaito M, Ma N, Semba R, Kamisako T, Adachi Y. Increased expression of multidrug resistance-associated protein 1 (mrp1) in hepatocyte basolateral membrane and renal tubular epithelia after bile duct ligation in rats. Hepatol Res 2002; 22: 58-64
44. Wolff NA, Thies K, Kuhnke N, Reid G, Friedrich B, Lang F, Burckhardt G. Protein kinase C activation downregulates human organic anion transporter 1-mediated transport through carrier internalization. J Am Soc Nephrol 2003; 14: 1959-1968
45. Karim Z, Defontaine N, Paillard M, Poggioli J. Protein kinase C isoforms in rat kidney proximal tubule: acute effect of angiotensin II. Am J Physiol 1995; 269: C134-C140
46. Rao YP, Stravitz RT, Vlahcevic ZR, Gurley EC, Sando JJ, Hylemon PB. Activation of protein kinase C alpha and delta by bile acids: correlation with bile acid structure and diacylglycerol formation. J Lipid Res 1997; 38: 2446-2454
47. Hirohata Y, Fujii M, Okabayashi Y, Nagashio Y, Tashiro M, Imoto I, Akiyama T, Otsuki M. Stimulatory effects of bilirubin on amylase release from isolated rat pancreatic acini. Am J Physiol Gastrointest Liver Physiol 2002; 282: G249-G256
48. Kwak JO, Kim HW, Oh KJ, Kim DS, Han KO, Cha SH. Colocalization and interaction of organic anion transporter 1 with caveolin-2 in rat kidney. Exp Mol Med 2005; 37: 204-212
49. Denk GU, Soroka CJ, Mennone A, Koepsell H, Beuers U, Boyer JL. Down-regulation of the organic cation transporter 1 of rat liver in obstructive cholestasis. Hepatology 2004; 39: 1382-1389
50. Denson LA, Bohan A, Held MA, Boyer JL. Organ-specific alterations in RAR alpha:RXR alpha abundance regulate rat Mrp2 (Abcc2) expression in obstructive cholestasis. Gastroenterology 2002; 123: 599-607
51. Rost D, Herrmann T, Sauer P, Schmidts HL, Stieger B, Meier PJ, Stremmel W, Stiehl A. Regulation of rat organic anion transporters in bile salt-induced cholestatic hepatitis: effect of ursodeoxycholate. Hepatology 2003; 38: 187-195
52. Boyer JL, Trauner M, Mennone A, Soroka CJ, Cai SY, Moustafa T, Zollner G, Lee JY, Ballatori N. Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents. Am J Physiol Gastrointest Liver Physiol 2006; 290: G1124-G1130