Blockade of beta-adrenergic signaling does not influence the bone mechano-adaptive response in mice

Bone

Volumn 41, Issue 2, 2007, Pages 206-215

  Marenzana, Massimo ^a   De Souza, Roberto L ^a   Chenu, Chantal ^a  

^a ROYAL VETERINARY COLLEGE   (United Kingdom)

Author keywords

Guanethidine sulfate; Mechanical loading; Neurectomy; Propranolol; Sympathetic nervous system

Indexed keywords

ADAPTATION; ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; ARTICLE; BETA ADRENERGIC RECEPTOR BLOCKING; BONE; BONE MASS; COMPARATIVE STUDY; CONTROLLED STUDY; CORTICAL BONE; FEMALE; GEOMETRY; MOUSE; NEURECTOMY; NONHUMAN; OSTEOLYSIS; SCIATIC NERVE; SIGNAL TRANSDUCTION; SYMPATHECTOMY; TIBIA; TRABECULAR BONE;

ADAPTATION, PHYSIOLOGICAL; ADRENERGIC AGENTS; ADRENERGIC BETA-ANTAGONISTS; ANIMALS; BODY WEIGHT; FEMALE; GUANETHIDINE; MICE; MICE, INBRED C57BL; PROPRANOLOL; RECEPTORS, ADRENERGIC, BETA; SIGNAL TRANSDUCTION; SPINE; STRESS, MECHANICAL; TIBIA; TOMOGRAPHY, X-RAY COMPUTED; WEIGHT-BEARING;

EID: 34347243130     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2007.04.184     Document Type: Article

References (57)

1. Frost H.M. Bone's mechanostat: a 2003 update. Anat Rec A Discov Mol Cell Evol Biol 275 (2003) 1081-1101
2. Lanyon L., Armstrong V., Ong D., Zaman G., and Price J. Is estrogen receptor alpha key to controlling bones' resistance to fracture?. J Endocrinol 182 (2004) 183-191
3. Chenu C., and Marenzana M. Sympathetic nervous system and bone remodeling. Joint Bone Spine 72 (2005) 481-483
4. Elefteriou F. Neuronal signaling and the regulation of bone remodeling. Cell Mol Life Sci 62 (2005) 2339-2349
5. Togari A., Arai M., and Kondo A. The role of the sympathetic nervous system in controlling bone metabolism. Expert Opin Ther Targets 9 (2005) 931-940
6. Elefteriou F., Ahn J.D., Takeda S., Starbuck M., Yang X., Liu X., et al. Leptin regulation of bone resorption by the sympathetic nervous system and CART. Nature 434 (2005) 514-520
7. Takeda S., Elefteriou F., Levasseur R., Liu X., Zhao L., Parker K.L., et al. Leptin regulates bone formation via the sympathetic nervous system. Cell 111 (2002) 305-317
8. Togari A., Arai M., Mizutani S., Mizutani S., Koshihara Y., and Nagatsu T. Expression of mRNAs for neuropeptide receptors and beta-adrenergic receptors in human osteoblasts and human osteogenic sarcoma cells. Neurosci Lett 233 (1997) 125-128
9. Bliziotes M., Murtagh J., and Wiren K. Beta-adrenergic receptor kinase-like activity and beta-arrestin are expressed in osteoblastic cells. J Bone Miner Res 11 (1996) 820-826
10. Kellenberger S., Muller K., Richener H., and Bilbe G. Formoterol and isoproterenol induce c-fos gene expression in osteoblast-like cells by activating beta2-adrenergic receptors. Bone 22 (1998) 471-478
11. Majeska R.J., and Rodan G.A. Alkaline phosphatase inhibition by parathyroid hormone and isoproterenol in a clonal rat osteosarcoma cell line. Possible mediation by cyclic AMP. Calcif Tissue Int 34 (1982) 59-66
12. Majeska R.J., Minkowitz B., Bastian W., and Einhorn T.A. Effects of beta-adrenergic blockade in an osteoblast-like cell line. J Orthop Res 10 (1992) 379-384
13. Arai M., Nagasawa T., Koshihara Y., Yamamoto S., and Togari A. Effects of beta-adrenergic agonists on bone-resorbing activity in human osteoclast-like cells. Biochim Biophys Acta 1640 (2003) 137-142
14. Takeuchi T., Tsuboi T., Arai M., and Togari A. Adrenergic stimulation of osteoclastogenesis mediated by expression of osteoclast differentiation factor in MC3T3-E1 osteoblast-like cells. Biochem Pharmacol 61 (2001) 579-586
15. Togari A. Adrenergic regulation of bone metabolism: possible involvement of sympathetic innervation of osteoblastic and osteoclastic cells. Microsc Res Tech 58 (2002) 77-84
16. Moore R.E., Smith C.K., Bailey C.S., Voelkel E.F., and Tashjian Jr. A.H. Characterization of beta-adrenergic receptors on rat and human osteoblast-like cells and demonstration that beta-receptor agonists can stimulate bone resorption in organ culture. Bone Miner 23 (1993) 301-315
17. Bonnet N., Benhamou C.L., Brunet-Imbault B., Arlettaz A., Horcajada M.N., Richard O., et al. Severe bone alterations under beta2 agonist treatments: bone mass, microarchitecture and strength analyses in female rats. Bone 37 (2005) 622-633
18. Kondo A., and Togari A. In vivo stimulation of sympathetic nervous system modulates osteoblastic activity in mouse calvaria. Am J Physiol Endocrinol Metab 285 (2003) E661-E667
19. Minkowitz B., Boskey A.L., Lane J.M., Pearlman H.S., and Vigorita V.J. Effects of propranolol on bone metabolism in the rat. J Orthop Res 9 (1991) 869-875
20. Pierroz D.D., Bouxsein M.L., Rizzoli R., and Ferrari S.L. Combined treatment with a beta-blocker and intermittent PTH improves bone mass and microarchitecture in ovariectomized mice. Bone 39 (2006) 260-267
21. Kondo H., Nifuji A., Takeda S., Ezura Y., Rittling S.R., Denhardt D.T., et al. Unloading induces osteoblastic cell suppression and osteoclastic cell activation to lead to bone loss via sympathetic nervous system. J Biol Chem 280 (2005) 30192-30200
22. Pasco J.A., Henry M.J., Sanders K.M., Kotowicz M.A., Seeman E., and Nicholson G.C. Beta-adrenergic blockers reduce the risk of fracture partly by increasing bone mineral density: Geelong Osteoporosis Study. J Bone Miner Res 19 (2004) 19-24
23. Levasseur R., Dargent-Molina P., Sabatier J.P., Marcelli C., and Breart G. Beta-blocker use, bone mineral density, and fracture risk in older women: results from the Epidemiologie de l'Osteoporose prospective study. J Am Geriatr Soc 53 (2005) 550-552
24. Reid I.R., Gamble G.D., Grey A.B., Black D.M., Ensrud K.E., Browner W.S., et al. beta-Blocker use, BMD, and fractures in the study of osteoporotic fractures. J Bone Miner Res 20 (2005) 613-618
25. Schlienger R.G., Kraenzlin M.E., Jick S.S., and Meier C.R. Use of beta-blockers and risk of fractures. JAMA 292 (2004) 1326-1332
26. Hert J.S.A., and Liskova M. Effect of intermittent stress on the rabbit tibia after resection of the peripheral nerves. Folia Morphol (Prague) XIX (1971) 378-387
27. Cheng M.Z., Zaman G., Rawlinson S.C., Pitsillides A.A., Suswillo R.F., and Lanyon L.E. Enhancement by sex hormones of the osteoregulatory effects of mechanical loading and prostaglandins in explants of rat ulnae. J Bone Miner Res 12 (1997) 1424-1430
28. Pitsillides A.A., Rawlinson S.C., Suswillo R.F., Bourrin S., Zaman G., and Lanyon L.E. Mechanical strain-induced NO production by bone cells: a possible role in adaptive bone (re)modeling?. FASEB J 9 (1995) 1614-1622
29. de Souza R.L., Pitsillides A.A., Lanyon L.E., Skerry T.M., and Chenu C. Sympathetic nervous system does not mediate the load-induced cortical new bone formation. J Bone Miner Res 20 (2005) 2159-2168
30. Levasseur R., Sabatier J.P., Potrel-Burgot C., Lecoq B., Creveuil C., and Marcelli C. Sympathetic nervous system as a transmitter of mechanical loading in bone. Joint Bone Spine 70 (2003) 515-519
31. De Souza R.L., Matsuura M., Eckstein F., Rawlinson S.C., Lanyon L.E., and Pitsillides A.A. Non-invasive axial loading of mouse tibiae increases cortical bone formation and modifies trabecular organization: a new model to study cortical and cancellous compartments in a single loaded element. Bone 37 (2005) 810-818
32. Fritton J.C., Myers E.R., Wright T.M., and van der Meulen M.C. Loading induces site-specific increases in mineral content assessed by microcomputed tomography of the mouse tibia. Bone 36 (2005) 1030-1038
33. Kodama Y., Umemura Y., Nagasawa S., Beamer W.G., Donahue L.R., Rosen C.R., et al. Exercise and mechanical loading increase periosteal bone formation and whole bone strength in C57BL/6J mice but not in C3H/Hej mice. Calcif Tissue Int 66 (2000) 298-306
34. Prut L., and Belzung C. The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review. Eur J Pharmacol 463 (2003) 3-33
35. Serre C.M., Farlay D., Delmas P.D., and Chenu C. Evidence for a dense and intimate innervation of the bone tissue, including glutamate-containing fibers. Bone 25 (1999) 623-629
36. Wada S., Kojo T., Wang Y.H., Ando H., Nakanishi E., Zhang M., et al. Effect of loading on the development of nerve fibers around oral implants in the dog mandible. Clin Oral Implants Res 12 (2001) 219-224
37. Mach D.B., Rogers S.D., Sabino M.C., Luger N.M., Schwei M.J., Pomonis J.D., et al. Origins of skeletal pain: sensory and sympathetic innervation of the mouse femur. Neuroscience 113 (2002) 155-166
38. Cavalie H., Lac G., Lebecque P., Chanteranne B., Davicco M.J., and Barlet J.P. Influence of clenbuterol on bone metabolism in exercised or sedentary rats. J Appl Physiol 93 (2002) 2034-2037
39. Moriyama I., Iwamoto J., Takeda T., and Toyama Y. Comparative effects of intermittent administration of human parathyroid hormone (1-34) on cancellous and cortical bone loss in tail-suspended and sciatic neurectomized young rats. J Orthop Sci 7 (2002) 379-385
40. Hanson A.M., Ferguson V.L., Simske S.J., Cannon C.M., and Stodieck S. Comparison of tail-suspension and sciatic nerve crush on the musculoskeletal system in young-adult mice. Biomed Sci Instrum 41 (2005) 92-96
41. Zeng Q.Q., Jee W.S., Bigornia A.E., King J.G., D'Souza S.M., Li X.J., et al. Time responses of cancellous and cortical bones to sciatic neurectomy in growing female rats. Bone 19 (1996) 13-21
42. Kodama Y., Dimai H.P., Wergedal J., Sheng M., Malpe R., Kutilek S., et al. Cortical tibial bone volume in two strains of mice: effects of sciatic neurectomy and genetic regulation of bone response to mechanical loading. Bone 25 (1999) 183-190
43. Sakata T., Sakai A., Tsurukami H., Okimoto N., Okazaki Y., Ikeda S., et al. Trabecular bone turnover and bone marrow cell development in tail-suspended mice. J Bone Miner Res 14 (1999) 1596-1604
44. Amblard D., Lafage-Proust M.H., Laib A., Thomas T., Ruegsegger P., Alexandre C., et al. Tail suspension induces bone loss in skeletally mature mice in the C57BL/6J strain but not in the C3H/HeJ strain. J Bone Miner Res 18 (2003) 561-569
45. Fu Q., Levine B.D., Pawelczyk J.A., Ertl A.C., Diedrich A., Cox J.F., et al. Cardiovascular and sympathetic neural responses to handgrip and cold pressor stimuli in humans before, during and after spaceflight. J Physiol 544 (2002) 653-664
46. McCarty R., Kvetnansky R., and Kopin I.J. Plasma catecholamines in rats: daily variations in basal levels and increments in response to stress. Physiol Behav 26 (1981) 27-31
47. Mueller P.J., and Hasser E.M. Enhanced sympathoinhibitory response to volume expansion in conscious hindlimb-unloaded rats. J Appl Physiol 94 (2003) 1806-1812
48. Morey-Holton E.R., Halloran B.P., Garetto L.P., and Doty S.B. Animal housing influences the response of bone to spaceflight in juvenile rats. J Appl Physiol 88 (2000) 1303-1309
49. Yirmiya R., Goshen I., Bajayo A., Kreisel T., Feldman S., Tam J., et al. Depression induces bone loss through stimulation of the sympathetic nervous system. Proc Natl Acad Sci U S A 103 (2006) 16876-16881
50. Cherruau M., Facchinetti P., Baroukh B., and Saffar J.L. Chemical sympathectomy impairs bone resorption in rats: a role for the sympathetic system on bone metabolism. Bone 25 (1999) 545-551
51. Sherman B.E., and Chole R.A. Sympathectomy, which induces membranous bone remodeling, has no effect on endochondral long bone remodeling in vivo. J Bone Miner Res 15 (2000) 1354-1360
52. Armstead C., Hamrick M., Pennington C., Azain M., Hartzell D., Pringle T., et al. Clenbuterol, a beta-adrenergic receptor agonist, increases lean mass but does not alter bone formation in mice. J Bone Miner Res 21 suppl 1 (2006) s188
53. Hill E.L., Turner R., and Elde R. Effects of neonatal sympathectomy and capsaicin treatment on bone remodeling in rats. Neuroscience 44 (1991) 747-755
54. Bonnet N., Laroche N., Vico L., Dolleans E., Benhamou C.L., and Courteix D. Dose effects of propranolol on cancellous and cortical bone in ovariectomized adult rats. J Pharmacol Exp Ther 318 (2006) 1118-1127
55. Pierroz D.D., Bouxsein M., Muzzin P., Rizzoli R., and Ferrari S.L. Bone loss following ovariectomy is maintained in absence of adrenergic receptor beta 1 and beta 2 signaling. J Bone Miner Res 20 suppl 1 (2005) s277
56. Pierroz D.D., Baldock P., Bouxsein M., and Ferrari S.L. Low cortical bone mass in mice lacking beta 1 and beta 2 adrenetgic receptors is associated with low bone formation and circulating IGF-1. J Bone Miner Res 21 suppl 1 (2006) s26
57. Dhillon H., Glatt V., Ferrari S.L., and Bouxsein M.L. Beta-adrenergic receptor KO mice have increased bone mass and strength but are not protected from ovariectomy induced bone loss. J Bone Miner Res 19 suppl 1 (2004) s32