Role of protein kinase Cδ in endothelin-induced type I collagen expression in cardiac myofibroblasts isolated from the site of myocardial infarction

Journal of Pharmacology and Experimental Therapeutics

Volumn 311, Issue 2, 2004, Pages 691-699

  Chintalgattu, Vishnu ^a   Katwa, Laxmansa C ^a  

^a EAST CAROLINA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CALPHOSTIN C; COLLAGEN TYPE 1; ENDOTHELIN 1; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PROTEIN KINASE C; PROTEIN KINASE C ALPHA; PROTEIN KINASE C BETA; PROTEIN KINASE C DELTA; PROTEIN KINASE C EPSILON; PROTEIN KINASE C ETA; PROTEIN KINASE C GAMMA; PROTEIN KINASE C INHIBITOR; PROTEIN KINASE C ZETA; PROTEIN P44; ROTTLERIN; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA DETERMINATION; ENZYME ACTIVITY; HEART INFARCTION; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PROTEIN INTERACTION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ACETOPHENONES; ANIMALS; APOPTOSIS; BENZOPYRANS; BINDING SITES; BLOTTING, WESTERN; COLLAGEN TYPE I; ENDOTHELINS; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLAVONOIDS; GENE EXPRESSION; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; MYOCARDIAL INFARCTION; MYOCYTES, CARDIAC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHOSPHORYLATION; PROTEIN KINASE C; PROTEIN KINASE C-DELTA; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SP1 TRANSCRIPTION FACTOR; TRANSCRIPTION FACTORS;

EID: 6344282286     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.104.070151     Document Type: Article

References (36)

1. Banchio C, Schang LM, and Vance DE (2003) Activation of CTP: phosphocholine cytidylyltransferase alpha expression during the S phase of the cell cycle is mediated by the transcription factor Sp1. J Biol Chem 278:32457-32464.
2. Bauersachs J, Braun C, Fraccarollo D, Widder J, Ertl G, Schilling L, Kirchengast M, and Rohmeiss P (2000) Improvement of renal dysfunction in rats with chronic heart failure after myocardial infarction by treatment with the endothelin A receptor antagonist, LU 135252. J Hypertens 18:1507-15014.
3. 2+-sensitive isoforms in the failing human heart. Circulation 99:384-391.
4. Campbell SE and Katwa LC (1997) Angiotensin II stimulated expression of transforming growth factor-beta1 in cardiac fibroblasts and myofibroblasts. J Mol Cell Cardiol 29:1947-1958.
5. Chen SJ, Artlett CM, Jimenez SA, and Varga J (1998) Modulation of human alpha1 (I) procollagen gene activity by interaction with Sp1 and Sp3 transcription factors in vitro. Gene 215:101-110.
6. Chintalgattu V, Nair DM, and Katwa LC (2003) Cardiac myofibroblasts: a novel source of vascular endothelial growth factor (VEGF) and its receptors Flt-1 and KDR. J Mol Cell Cardiol 35:277-286.
7. Clerk A, Bogoyevitch MA, Anderson MB, and Sugden PH (1994) Differential activation of protein kinase C isoforms by endothelin-1 and phenylephrine and subsequent stimulation of p42 and p44 mitogen-activated protein kinases in ventricular myocytes cultured from neonatal rat hearts. J Biol Chem 269:32848-32857.
8. Czuwara-Ladykowska J, Shirasaki F, Jackers P, Watson DK, and Trojanowska M (2001) Fli-1 inhibits collagen type I production in dermal fibroblasts via an Sp1-dependent pathway. J Biol Chem 276:20839-20848.
9. D'Angelo DD, Sakata Y, Lorenz JN, Boivin G, Walsh RA, Liggett SB, and Dorn GW II (1997) Transgenic Gαq overexpression induces cardiac contractile function in mice. Proc Natl Acad Sci USA 94:8121-8126.
10. Dunnmon PM, Iwaki K, Henderson SA, Sen A, and Chien KR (1990) Phorbol esters induce immediate-early genes and activate cardiac gene transcription in neonatal rat myocardial cells. J Mol Cell Cardiol 22:901-910.
11. Fraccarollo D, Galuppo P, Bauersachs J, and Ertl G (2002) Collagen accumulation after myocardial infarction: effects of ETA receptor blockade and implications for early remodeling. Cardiovasc Res 54:559-567.
12. Garcia-Ruiz I, de la Torre P, Diaz T, Esteban E, Fernandez I, Munoz-Yague T, and Solis-Herruzo JA (2002) Sp1 and Sp3 transcription factors mediate malondialdehyde-induced collagen alpha 1(I) gene expression in cultured hepatic stellate cells. J Biol Chem 277:30551-30558.
13. Gschwendt M, Muller HJ, Kielbassa K, Zang R, Kittstein W, Rincke G, and Marks F (1994) Rottlerin, a novel protein kinase inhibitor. Biochem Biophys Res Commun 199:93-98.
14. Guarda E, Katwa LC, Myers PR, Tyagi SC, and Weber KT (1993) Effects of endothelins on collagen turnover in cardiac fibroblasts. Cardiovasc Res 27:2130-2134.
15. Hua H, Goldberg HJ, Fantus IG, and Whiteside CI (2001) High glucose-enhanced mesangial cell extracellular signal-regulated protein kinase activation and alpha1 (IV) collagen expression in response to endothelin-1: role of specific protein kinase C isoenzymes. Diabetes 50:2376-2383.
16. Ihn H and Tamaki K (2000) Increased phosphorylation of transcription factor Sp1 in scleroderma fibroblasts: association with increased expression of the type I collagen gene. Arthritis Rheum 43:2240-2247.
17. Jimenez SA, Gaidarova S, Saitta B, Sandorfi N, Herrich DJ, Rosenbloom JC, Kucich U, Abrams WR, and Rosenbloom J (2001) Role of protein kinase C-delta in the regulation of collagen gene expression in scleroderma fibroblasts. J Clin Investig 108:1395-1403.
18. Katwa LC (2003) Cardiac myofibroblasts isolated from the site of myocardial infarction express endothelin de novo. Am J Physiol Heart Circ Physiol 285:H1132-H1139.
19. Katwa LC, Campbell SE, Tyagi SC, Lee SJ, Cicila GT, and Weber KT (1997) Cultured myofibroblasts generate angiotensin peptides de novo. J Mol Cell Cardiol 29:1375-1386.
20. Kucich U, Rosenbloom JC, Abrams WR, and Rosenbloom J (2002) Transforming growth factor-beta stabilizes elastin mRNA by a pathway requiring active Smads, protein kinase C-delta and p38. Am J Respir Cell Mol Biol 26:183-188.
21. Li L, Artlett CM, Jimenez SA, Hall DJ, and Varga J (1995) Positive regulation of human alpha 1 (I) collagen promoter activity by transcription factor Sp1. Gene 164:229-234.
22. Mackay K and Mochly-Rosen D (2001) Localization, anchoring and functions of protein kinase C isoenzymes in the heart. J Mol Cell Cardiol 33:1301-1307.
23. Martiny-Baron G, Kazanietz MG, Mischak H, Blumberg PM, Kochs G, Hug H, Manné D, and Schächtele C (1993) Selective inhibition of protein kinase C isoenzymes by indolocarbazole Gö 6976. J Biol Chem 268:9194-9197.
24. Miyamae M, Rodriguez MM, Camacho SA, Diamond I, Mochly-Rosen D, and Figueredo VM (1998) Activation of eprotein kinase C correlates with a cardioprotective effect of regular ethanol consumption. Proc Natl Acad Sci USA 95:8262-8267.
25. Mulder P, Boujedaini H, Richard V, Derumeaux G, Henry JP, Renet S, Wessale J, Opgenorth T, and Thuillez C (2000) Selective endothelin-A versus combined endothelin-A/endothelin-B receptor blockade in rat chronic heart failure. Circulation 102:491-503.
26. Nguyen QT, Cernacek P, Calderoni A, Stewart DJ, Picard P, Sirois P, White M, and Rouleau JL (1998) Endothelin A receptor blockade causes adverse left ventricular remodeling but improves pulmonary artery pressure after infarction in the rat. Circulation 98:2323-2330.
27. Nguyen QT, Cernacek P, Sirois MG, Calderone A, Lapointe N, Stewart DJ, and Rouleau JL (2001) Long-term effects of nonselective endothelin A and B receptor antagonism in postinfarction rat: importance of timing. Circulation 104:2075-2081.
28. Palcy S and Goltzman D (1999) Protein kinase signalling pathways involved in the up-regulation of the rat alpha1 (I) collagen gene by transforming growth factor beta1 and bone morphogenetic protein 2 in osteoblastic cells. Biochem J 343:21-27.
29. Pfeffer JM, Finn PV, Zornoff LA, and Pfeffer MA (2000) Endothelin-A receptor antagonism during acute myocardial infarction in rats. Cardiovasc Drugs Ther 14:579-587.
30. Qiu Y, Ping P, Tang X-L, Manchikalapudi S, Rizvi A, Zhang J, Takano H, Wu WJ, Teschner S, and Bolli R (1998) Direct evidence that protein kinase C plays an essential role in the development of late preconditioning against myocardial stunning in conscious rabbits and that epsilon is the isoform involved. J Clin Investig 101:2182-2198.
31. Rodriguez-Barbero A, Obreo J, Yuste L, Montero JC, Rodriguez-Pena A, Pandiella A, Bernabeu C, and Lopez-Novoa JM (2002) Transforming growth factor-beta1 induces collagen synthesis and accumulation via p38 mitogen-activated protein kinase (MAPK) pathway in cultured L(6)E(9) myoblasts. FEBS Lett 513:282-288.
32. Rossi GP, Cesari M, and Pessina AC (1999) Endothelins and cardiac fibrosis. Hypertension 34:e1.
33. Ruiz IG, de la Torre P, Diaz T, Esteban E, Morillas JD, Munoz-Yague T, and Solis-Herruzo JA (2000) Sp family of transcription factors is involved in iron-induced collagen alpha1 (I) gene expression. DNA Cell Biol 19:167-178.
34. Runyan CE, Schnaper HW, and Poncelet AC (2003) Smad3 and PKC δ mediate TGF-beta1-induced collagen I expression in human mesangial cells. Am J Physiol Renal Physiol 285:F413-F422.
35. Sun Y, Zhang JQ, Zhang J, and Lamparter S (2000) Cardiac remodeling by fibrous tissue after infarction in rats. J Lab Clin Med 135:316-323.
36. Thai HM, Van HT, Gaballa MA, Goldman S, and Raya TE (1999) Effects of AT1 receptor blockade after myocardial infarct on myocardial fibrosis, stiffness and contractility. Am J Physiol 276:H873-H880.