The role of keratins in epidermal development and homeostasis - Going beyond the obvious

Journal of Investigative Dermatology

Volumn 123, Issue 5, 2004, Pages

  Koch, Peter J ^a   Roop, Dennis R ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

KERATIN; KERATIN 10; STRUCTURAL PROTEIN; UNCLASSIFIED DRUG;

CELL PROLIFERATION; CELL TYPE; CYTOSKELETON; DEVELOPMENT; EPIDERMIS; HOMEOSTASIS; HUMAN; INTERMEDIATE FILAMENT; NONHUMAN; NOTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SKIN CANCER;

EID: 6344272398     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0022-202X.2004.23495.x     Document Type: Note

References (20)

1. Cheng X, Koch PJ: In vivo function of desmosomes. J Dermatol 31:171-187, 2004
2. Hesse M, Zimek A, Weber K, Magin TM: Comprehensive analysis of keratin gene clusters in humans and rodents. Eur J Cell Biol 83:19-26, 2004
3. Hutton E, Paladini RD, Yu QC, Yen M, Coulombe PA, Fuchs E: Functional differences between keratins of stratified and simple epithelia. J Cell Biol 143:487-499, 1998
4. Irvine AD, McLean WH: Human keratin diseases: The increasing spectrum of disease and subtlety of the phenotype-genotype correlation. Br J Dermatol 140:815-828, 1999
5. Nievers MG, Schaapveld RQ, Sonnenberg A: Biology and function of hemidesmosomes. Matrix Biol 18:5-17, 1999
6. Nischt R, Roop DR, Mehrel T, Yuspa SH, Rentrop M, Winter H, Schweizer J: Aberrant expression during two-stage mouse skin carcinogenesis of a type I 47-kDa keratin, K13, normally associated with terminal differentiation of internal stratified epithelia. Mol Carcinog 1:96-108, 1988
7. Paladini RD, Coulombe PA: The functional diversity of epidermal keratins revealed by the partial rescue of the keratin 14 null phenotype by keratin 16. J Cell Biol 146:1185-1201, 1999
8. Paramio JM, Casanova ML, Alonso A, Jorcano JL: Keratin intermediate filament dynamics in cell heterokaryons reveals diverse behaviour of different keratins. J Cell Sci 110 (Pt 9):1099-1111, 1997
9. Paramio JM, Casanova ML, Segrelles C, Mittnacht S, Lane EB, Jorcano JL: Modulation of cell proliferation by cytokeratins K10 and K16. Mol Cell Biol 19:3086-3094, 1999
10. Paramio JM, Jorcano JL: Transient transfections and heterokaryons as tools for the analysis of keratin IF dynamics. Methods Mol Biol 161:189-197, 2001
11. Paramio JM, Jorcano JL: Beyond structure: Do intermediate filaments modulate cell signalling? Bioessays 24:836-844, 2002
12. Reichelt J, Bussow H, Grund C, Magin TM: Formation of a normal epidermis supported by increased stability of keratins 5 and 14 in keratin 10 null mice. Mol Biol Cell 12:1557-1568, 2001
13. Reichelt J, Magin TM: Hyperproliferation, induction of c-Myc and 14-3-3sigma, but no cell fragility in keratin-10-null mice. J Cell Sci 115:2639-2650, 2002
14. Reichelt J, Furstenberger G, Magin TM: Loss of keratin 10 leads to MAP kinase activation, increased keratinocyte turnover and decreased tumor formation in mice. J Invest Dermatol 123:973-981, 2004
15. Roop DR, Krieg TM, Mehrel T, Cheng CK, Yuspa SH: Transcriptional control of high molecular weight keratin gene expression in multistage mouse skin carcinogenesis. Cancer Res 48:3245-3252, 1983
16. Santos M, Bravo A, Lopez C, Paramio JM, Jorcano JL: Severe abnormalities in the oral mucosa induced by suprabasal expression of epidermal keratin K10 in transgenic mice. J Biol Chem 277:35371-35377, 2002a
17. Santos M, Paramio JM, Bravo A, Ramirez A, Jorcano JL: The expression of keratin k10 in the basal layer of the epidermis inhibits cell proliferation and prevents skin tumorigenesis. J Biol Chem 277:19122-19130, 2002b
18. Santos M, Perez P, Segrelles C, Ruiz S, Jorcano JL, Paramio JM: Impaired NF-kappa B activation and increased production of tumor necrosis factor alpha in transgenic mice expressing keratin. J Biol Chem 278:13422-13430, 2003
19. Waikel RL, Kawachi Y, Waikel PA, Wang XJ, Roop DR: Deregulated expression of c-Myc depletes epidermal stem cells. Nat Genet 28:165-168, 2001
20. Wang XJ, Greenhalgh DA, Jiang A, et al: Expression of a p53 mutant in the epidermis of transgenic mice accelerates chemical carcinogenesis. Oncogene 17:35-45, 1998