Synthesis and antifolate activity of new pyrrolo[2,3-d]pyrimidine and thieno[2,3-d]pyrimidine inhibitors of dihydrofolate reductase

Journal of Heterocyclic Chemistry

Volumn 41, Issue 5, 2004, Pages 787-793

  Vaidya, Chitra ^a   Wright, Joel E ^a   Rosowsky, Andre ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROFOLATE REDUCTASE INHIBITOR; FOLIC ACID ANTAGONIST; N [4 [N [(2,4 DIAMINOTHIENO[2,3 D]PYRIMIDIN 5 YL)METHYL]AMINO]BENZOYL]GLUTAMIC ACID; NALPHA (4 AMINO 4 DEOXYPTEROYL) NDELTA HEMIPHTHALOYLORNITHINE; NALPHA [4 [N [(2,4 DIAMINOPYRROLO[2,3 D]PYRIMIDIN 5 YL)METHYL]AMINO]BENZOYL] NDELTA HEMIPHTHALOYLORNITHINE; NALPHA [4 [N [(2,4 DIAMINOTHIENO[2,3 D]PYRIMIDIN 5 YL)METHYL]AMINO]BENZOYL]GLUTAMIC ACID; PYRROLO[2,3 D]PYRIMIDINE DERIVATIVE; THIENO[2,3 D]PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; BINDING ASSAY; CANCER CELL CULTURE; CANCER GROWTH; CONTROLLED STUDY; DRUG ACTIVITY; DRUG PROTEIN BINDING; DRUG SYNTHESIS; ENZYME INHIBITION; GROWTH INHIBITION; HUMAN; HUMAN CELL; LEUKEMIA CELL;

EID: 6344269171     PISSN: 0022152X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jhet.5570410523     Document Type: Article

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