2,4-Diaminothieno[2,3-d]pyrimidine lipophilic antifolates as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase

Journal of Medicinal Chemistry

Volumn 40, Issue 22, 1997, Pages 3694-3699

  Rosowsky, Andre ^a   Papoulis, Andrew T ^a   Queener, Sherry F ^b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIAMINO 5 [3,5 DICHLORO 4 (1 PYRROLO)ANILINO]METHYL] 6 BROMOTHIENO[2,3 D]PYRIMIDINE; DIHYDROFOLATE REDUCTASE INHIBITOR; FOLIC ACID ANTAGONIST; UNCLASSIFIED DRUG;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL TISSUE; ANTIPROTOZOAL ACTIVITY; ARTICLE; ENZYME INHIBITION; INFECTION RISK; NONHUMAN; PNEUMOCYSTIS PNEUMONIA; RAT; TOXOPLASMOSIS;

ANIMALS; ENZYME INHIBITORS; FOLIC ACID ANTAGONISTS; LIVER; MAGNETIC RESONANCE SPECTROSCOPY; PNEUMOCYSTIS; PYRIMIDINES; RATS; TETRAHYDROFOLATE DEHYDROGENASE; THIOPHENES; TOXOPLASMA;

EID: 0030693168     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970399a     Document Type: Article

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