PT523 and other aminopterin analogs with a hemiphthaloyl-L-ornithine side chain: Exceptionally tight-binding inhibitors of dihydrofolate reductase which are transported by the reduced folate carrier but cannot form polyglutamates

Current Medicinal Chemistry

Volumn 6, Issue 4, 1999, Pages 329-352

  Rosowsky, Andre ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [5 [[(1,2 DIHYDRO 3 METHYL 1 OXOBENZO[F]QUINAZOLIN 9 YL)METHYL]AMINO] 1 OXO 2 ISOINDOLINYL]GLUTARIC ACID; AMINOPTERIN DERIVATIVE; DIHYDROFOLATE REDUCTASE; DIHYDROFOLATE REDUCTASE INHIBITOR; EDATREXATE; ETOPOSIDE; FOLIC ACID; FOLIC ACID ANTAGONIST; FOLINIC ACID; FUNCTIONAL GROUP; GLYCOPROTEIN P; LOMETREXOL; METHOTREXATE; NALPHA (4 AMINO 4 DEOXYPTEROYL) NDELTA HEMIPHTHALOYLORNITHINE; NOVOBIOCIN; ORNITHINE DERIVATIVE; POLYGLUTAMIC ACID; PT 608; PT 609; PT 613; PT 615; PT 621; PTERIDINE; PURINE; RALTITREXED; THYMIDINE PHOSPHATE; TRIMETREXATE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VINCRISTINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; AREA UNDER THE CURVE; ASCITES TUMOR; BINDING AFFINITY; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; DRUG CLEARANCE; DRUG HALF LIFE; DRUG MECHANISM; DRUG METABOLISM; DRUG POTENTIATION; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TRANSPORT; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MEAN RESIDENCE TIME; MOUSE; NONHUMAN; PURINE SYNTHESIS; RAT; REVIEW; SOLID TUMOR; TISSUE DISTRIBUTION; TUMOR CELL LINE;

AMINOPTERIN; ANIMALS; ANTINEOPLASTIC AGENTS; DNA DAMAGE; FOLIC ACID ANTAGONISTS; HUMANS; ORNITHINE; P-GLYCOPROTEIN; POLYGLUTAMIC ACID; PTERINS; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROFOLATE DEHYDROGENASE; TISSUE DISTRIBUTION;

EID: 0032909596     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

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