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Volumn 48, Issue 9, 2000, Pages 1270-1280
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Non-glutamate type pyrrolo[2,3-d]pyrimidine antifolates. III. Synthesis and biological properties of N(ω)-masked ornithine analogs
a
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Author keywords
Antifolate; Dihydrofolate reductase inhibition; Methotrexate resistant tumor; N( ) masked ornithine; Pyrrolo 2,3 d pyrimidine; TNP 351
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Indexed keywords
ALKANOIC ACID;
CARBAMIC ACID DERIVATIVE;
DIAMINO ACID;
DIHYDROFOLATE REDUCTASE;
EDATREXATE;
ESTER;
FOLIC ACID;
FOLIC ACID ANTAGONIST;
FUNCTIONAL GROUP;
GLUTAMIC ACID;
HEMIPHTHALOYL ORNITHINE DERIVATIVE;
LOMETREXOL;
METHOTREXATE;
N ALPHA [4 [2 (2,4 DIAMINO 7H PYRROLO[2,3 D]PYRIMIDIN 5 YL)ETHYL]BENZOYL] N DELTA (4 FLUOROPHENYLCARBAMOYL)ORNITHINE;
N ALPHA [4 [2 (2,4 DIAMINO 7H PYRROLO[2,3 D]PYRIMIDIN 5 YL)ETHYL]BENZOYL]AMINO N DELTA (2 PYRROLIDINOCARBONYLBENZOYL)ORNITHINE;
N ALPHA [4 [3 (2,4 DIAMINO 7H PYRROLO[2,3 D]PYRIMIDIN 5 YL)PROPYL]BENZOYL] N DELTA BENZYLOXYCARBONYLORNITHINE;
N DELTA (TERT BUTOXYCARBONYL) N ALPHA [4 [2 (2,4 DIAMINO 7H PYRROLO[2,3 D]PYRIMIDIN 5 YL)ETHYL]BENZOYL]ORNITHINE;
N [4 [3 (2,4 DIAMINO 7H PYRROLO[2,3 D]PYRIMIDIN 5 YL)PROPYL]BENZOYL]GLUTAMIC ACID;
ORNITHINE DERIVATIVE;
PYRROLO[2,3 D]PYRIMIDINE DERIVATIVE;
RALTITREXED;
SULFONIC ACID DERIVATIVE;
TRIMETREXATE;
UNCLASSIFIED DRUG;
ACUTE LYMPHOBLASTIC LEUKEMIA;
ACYLATION;
ANIMAL CELL;
ANTINEOPLASTIC ACTIVITY;
ARTICLE;
CANCER INHIBITION;
CELL GROWTH;
DRUG SYNTHESIS;
DRUG UPTAKE;
ENZYME INHIBITION;
FIBROSARCOMA;
HUMAN;
HUMAN CELL;
HYDROLYSIS;
MASKING;
MOUSE;
NONHUMAN;
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EID: 0033781093
PISSN: 00092363
EISSN: None
Source Type: Journal
DOI: 10.1248/cpb.48.1270 Document Type: Article |
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Times cited : (16)
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References (29)
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