Interrelationships among Atg proteins during autophagy in Saccharomyces cerevisiae

Yeast

Volumn 21, Issue 12, 2004, Pages 1057-1065

  Suzuki, Kuninori ^a   Noda, Takeshi ^a,b   Ohsumi, Yoshinori ^a  

^a NATIONAL INSTITUTE FOR BASIC BIOLOGY   (Japan)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

ATG; Autophagosome; Autophagy; GFP; Membrane dynamics; Pre autophagosomal structure; Yeast

Indexed keywords

FUNGAL PROTEIN; GREEN FLUORESCENT PROTEIN; PROTEIN ATG; UNCLASSIFIED DRUG;

ARTICLE; ATG GENE; AUTOPHAGOSOME; AUTOPHAGY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; EPISTASIS; FLUORESCENCE MICROSCOPY; FUNGAL GENE; IMMUNOBLOTTING; NONHUMAN; NUTRIENT; PHAGOSOME; PHENOTYPE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SACCHAROMYCES CEREVISIAE;

AUTOPHAGY; CELL MEMBRANE; MEMBRANE PROTEINS; MICROSCOPY, FLUORESCENCE; MICROTUBULE-ASSOCIATED PROTEINS; MUTATION; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; VACUOLES;

EUKARYOTA; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 6344263869     PISSN: 0749503X     EISSN: None     Source Type: Journal    
DOI: 10.1002/yea.1152     Document Type: Article

References (34)

1. Adams A, Gottschling DE, Kaiser CA, Stearns T (eds). 1998. Methods in Yeast Genetics. Cold Spring Harbor Laboratory Press: New York.
2. Barth H, Meiling-Wesse K, Epple UD, Thumm M. 2001. Autophagy and the cytoplasm to vacuole targeting pathway both require Aut10p. FEBS Lett 508: 23-28.
3. Funakoshi T, Matsuura A, Noda T, Ohsumi Y. 1997. Analyses of APG13 gene involved in autophagy in yeast, Saccharomyces cerevisiae. Gene 192: 207-213.
4. Gavin AC, Bosche M, Krause R, et al. 2002. Functional organization of the yeast proteome by systematic analysis of protein complexes. Nature 415: 141-147.
5. Giaever G, Chu AM, Ni L, et al. 2002. Functional profiling of the Saccharomyces cerevisiae genome. Nature 418: 387-391.
6. Guan J, Stromhaug PE, George MD, et al. 2001. Cvt18/Gsa12 is required for cytoplasm-to-vacuole transport, pexophagy, and autophagy in Saccharomyces cerevisiae and Pichia pastoris. Mol Biol Cell 12: 3821-3838.
7. Harding TM, Morano KA, Scott SV, Klionsky DJ. 1995. Isolation and characterization of yeast mutants in the cytoplasm to vacuole protein targeting pathway. J Cell Biol 131: 591-602.
8. Ho Y, Gruhler A, Heilbut A, et al. 2002. Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature 415: 180-183.
9. Huang WP, Scott SV, Kim J, Klionsky DJ. 2000. The itinerary of a vesicle component, Aut7p/Cvt5p, terminates in the yeast vacuole via the autophagy/Cvt pathways. J Biol Chem 275: 5845-5851.
10. Ichimura Y, Kirisako T, Takao T, et al. 2000. A ubiquitin-like system mediates protein lipidation. Nature 408: 488-492.
11. Kamada Y, Funakoshi T, Shintani T, et al. 2000. Tor-mediated induction of autophagy via an Apg1 protein kinase complex. J Cell Biol 150: 1507-1513.
12. Kametaka S, Matsuura A, Wada Y, Ohsumi Y. 1996. Structural and functional analyses of APG5, a gene involved in autophagy in yeast. Gene 178: 139-143.
13. Kametaka S, Okano T, Ohsumi M, Ohsumi Y. 1998. Apg14p and Apg6Nps30p form a protein complex essential for autophagy in the yeast, Saccharomyces cerevisiae. J Biol Chem 273: 22 284-22 291.
14. Kihara A, Noda T, Ishihara N, Ohsumi Y. 2001. Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae. J Cell Biol 152: 519-530.
15. Kim J, Dalton VM, Eggerton KP, et al. 1999. Apg7p/Cvt2p is required for the cytoplasm-to-vacuole targeting, macroautophagy, and peroxisome degradation pathways. Mol Biol Cell 10: 1337-1351.
16. Kim J, Huang WP, Stromhaug PE, Klionsky DJ. 2002. Convergence of multiple autophagy and cytoplasm to vacuole targeting components to a perivacuolar membrane compartment prior to de novo vesicle formation. J Biol Chem 277: 763-773.
17. Kirisako T, Baba M, Ishihara N, et al. 1999. Formation process of autophagosome is traced with Apg8/Aut7p in yeast. J Cell Biol 147: 435-446.
18. Kirisako T, Ichimura Y, Okada H, et al. 2000. The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathway. J Cell Biol 151: 263-276.
19. Klionsky DJ, Cregg JM, Dunn WA, et al. 2003. A unified nomenclature for yeast autophagy-related genes. Dev Cell 5: 539-545.
20. Kuma A, Mizushima N, Ishihara N, Ohsumi Y. 2002. Formation of the 350 kDa Apg12-Apg5. Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeast. J Biol Chem 277: 18 619-18 625.
21. Matsuura A, Tsukada M, Wada Y, Ohsumi Y. 1997. Apg1p, a novel protein kinase required for the autophagic process in Saccharomyces cerevisiae. Gene 192: 245-250.
22. Mizushima N, Noda T, Yoshimori T, et al. 1998. A protein conjugation system essential for autophagy. Nature 395: 395-398.
23. Nice DC, Sato TK, Stromhaug PE, et al. 2002. Cooperative binding of the cytoplasm to vacuole targeting pathway proteins, Cvt13 and Cvt20, to phosphatidylinositol 3-phosphate at the preautophagosomal structure is required for selective autophagy. J Biol Chem 277: 30 198-30 207.
24. Noda T, Kim J, Huang WP, et al. 2000. Apg9p/Cvt7p is an integral membrane protein required for transport vesicle formation in the Cvt and autophagy pathways. J Cell Biol 148: 465-480.
25. Noda T, Ohsumi Y. 1998. Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast. J Biol Chem 273: 3963-3966.
26. Reggiori F, Klionsky DJ. 2002. Autophagy in the eukaryotic cell. Eukaryot Cell 1: 11-21.
27. Robinson JS, Klionsky DJ, Banta LM, Emr SD. 1988. Protein sorting in Saccharomyces cerevisiae: isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolases. Mol Cell Biol 8: 4936-4948.
28. Shintani T, Mizushima N, Ogawa Y, et al. 1999. Apg10p, a novel protein-conjugating enzyme essential for autophagy in yeast. EMBO J 18: 5234-5241.
29. Shintani T, Suzuki K, Kamada Y, et al. 2001. Apg2p functions in autophagosome formation on the perivacuolar structure. J Biol Chem 276: 30452-30460.
30. Suzuki K, Kirisako T, Kamada Y, et al. 2001. The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation. EMBO J 20: 5971-5981.
31. Tanida I, Mizushima N, Kiyooka M, et al. 1999. Apg7p/Cvt2p: A novel protein-activating enzyme essential for autophagy. Mol Biol Cell 10: 1367-1379.
32. Thumm M, Egner R, Koch B, et al. 1994. Isolation of autophagocytosis mutants of Saccharomyces cerevisiae. FEBS Lett 349: 275-280.
33. Tsukada M, Ohsumi Y. 1993. Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae. FEBS Lett 333: 169-174.
34. Wang CW, Kim J, Huang WP, et al. 2001. Apg2 is a novel protein required for the cytoplasm to vacuole targeting, autophagy, and pexophagy pathways. J Biol Chem 276: 30 442-30 451.