The Traceless Solid-Phase Synthesis of Organic Molecules

Methods in Enzymology

Volumn 369, Issue , 2003, Pages 164-182

  Tumelty, David ^a   Pan, Yijun ^a   Holmes, Christopher P ^a  

^a AFFYMAX RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZIMIDAZOLE DERIVATIVE; ORGANIC COMPOUND; PHENOL;

AMINATION; ARTICLE; CATALYSIS; CHEMICAL REACTION; CHEMICAL STRUCTURE; PRIORITY JOURNAL; SOLID; SOLID PHASE SYNTHESIS; SYNTHESIS;

EID: 0346847646     PISSN: 00766879     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0076-6879(03)69009-9     Document Type: Article

References (27)

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14. To further elucidate this point, we were able to remove from the resin about four-fifths of the quaternized target compound that had been synthesized (this was judged using the double-linker approach mentioned above). The variability in the actual amount of target material synthesized on (and competent to be released from) the resin was dictated by the reaction (in)compatibility of the three monomers comprising each individual benzimidazole compound.
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