Synthesis and antiviral activity of new benzothiadiazine dioxide derivatives

Journal of Heterocyclic Chemistry

Volumn 41, Issue 5, 2004, Pages 747-753

  Tait, Annalisa ^a   Luppi, Amedeo ^a   Cermelli, Claudio ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

3 (2 CHLOROBENZYL) 1 (4 NITROBENZYL) 1H 2,1,3 BENZOTHIADIAZIN 4(3H) ONE 2,2 DIOXIDE; 3 (2 PHENYLETHYL) 1 (2 PYRIDYLETHYL) 1H 2,1,3 BENZOTHIADIAZIN 4(3H) ONE 2,2 DIOXIDE; 3 BENZYL 1 (4 PYRIDIYLMETHYL) 1H 2,1,3 BENZOTHIAZIDIN 4(3H) ONE 2,2 DIOXIDE; 7 CHLORO 3 (2 CHLOROBENZYL) 1 (3,5 DI TERT BUTYL 4 HYDROXYBENZYL) 1H 2,1,3 BENZOTHIADIAZIN 4(3H) ONE 2,2 DIOXIDE; BENZOTHIADIAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ADENOVIRUS; ALKYLATION; ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; COXSACKIE VIRUS; COXSACKIE VIRUS B5; DRUG CYTOTOXICITY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; HUMAN HERPESVIRUS 6; MITSUNOBU REACTION; NONHUMAN; STRUCTURE ACTIVITY RELATION; VIRUS STRAIN;

EID: 6344225826     PISSN: 0022152X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jhet.5570410516     Document Type: Article

References (26)

1. E. De Clercq, Nature Reviews Drug Discovery, 1, 13 (2002).
2. A. Martinez, A. I. Esteban and E. De Clercq, Bioorg. Med. Chem. Lett. 7, 1031 (1997)
3. A. Martinez, C. Gil, C. Perez, A. Castro, C. Prieto and J. Otero, Bioorg. Med. Chem. Lett., 9, 3133 (1999).
4. A. Martinez, A. I. Esteban, A. Castro, C. Gil, S. Conde, G. Andrei, R. Snoeck, J. Balzarini and E. De Clercq, J. Med. Chem., 42, 1145 (1999).
5. A. Martinez, C. Gil, M. I. Abasolo, A. Castro, A. M. Bruno, C. Perez, C. Prieto and J. Otero, J. Med. Chem., 43, 3218 (2000).
6. A. Martinez, C. Gil, C. Perez, A. Castro, C. Prieto, J. Otero, G. Andrei, R. Snoeck, J. Balzarini and E. De Clercq, J. Med. Chem. 43, 3267 (2000).
7. A. Martinez, C. Gil, A. Castro, C. Pérez, C. Prieto and J. Otero, Bioorg. Med. Chem., 11, 2395 (2003).
8. A. Martinez, A. I. Esteban, A. Herrero, C. Ochoa, G. Andrei, R. Snoeck, J. Balzarini and E. De Clercq, Bioorg. Med. Chem, 7, 1617 (1999).
9. R. Di Santo, R. Costi, M. Artico, S. Massa, M. E. Marongiu, A. G. Loi, A. De Montis and P. La Colla, Antivir. Chem. Chemother., 9, 127 (1998).
10. M. E. Arranz, J. A. Diaz, S. T. Ingate, M. Witvrouw, C. Pannecouque, J. Balzarini, E. De Clercq and S. Vega, Bioorg. Med. Chem., 7, 2811 (1999).
11. A. Martinez, A. Castro, C. Gil, M. Miralpeix, V. Segarra, T. Domenech, J. Beleta, J. M. Palacios, H. Ryder, X. Miro, C. Bonet, J. M. Casacuberta, F. Azorin, B. Pina and P. Puigdomenech, J. Med. Chem., 43, 683 (2000).
12. A. Castro, M. I. Abasolo, C. Gil, V. Segarra and A. Martinez, Eur. J. Med. Chem., 36, 333 (2001).
13. D. Braghiroli, G. Puia, G. Cannazza, A. Tait, C. Parenti, G. Losi and M. Baraldi, J. Med. Chem., 45, 2355 (2002).
14. G. Cannazza, D. Braghiroli, A. Tait, M. Baraldi, C. Parenti and W. Lindner, Chirality, 13, 94 (2001).
15. A. Tait, E. Colorni and M. Di Bella, Tetrahedron Asymmetry, 8, 2199 (1997).
16. A. Tait, S. Ganzerli and M. Di Bella, Tetrahedron, 52, 12587 (1996).
17. O. Mitsunobu, Synthesis, 1981, 1.
18. E. Cohen and B. Klarberg, J. Am. Chem. Soc., 84, 1994 (1962).
19. A. Castro, C. Gil and A. Martinez, Tetrahedron, 55, 12405 (1999).
20. G. Dewynter, N. Aouf, Z. Regainia and J. L. Montero, Tetrahedron, 52, 993 (1996).
21. D. L. Simmons, J. M. Dodsworth, Francis L. Chubb and W. Frank, Can. J. Chem., 41, 804 (1963)
22. S. A. Plotkin, T. Furukawa, N. Zygraich and C. Huygelen, Infect. Immun., 12, 521 (1975).
23. D. V. Ablashi, N. Balachandran, S. F. Josephs, C. L. Hung, G. R. Krueger, B. Kramarsky, S. Z. Salahuddin and R. C. Gallo, Virology, 184, 545 (1991).
24. F. Denizot and R. Lang, J. Immuno. Methods, 89, 271 (1986).
25. E. H. Lennette, in Diagnostic Procedures of Virus and Rickettsia Disease, ed, American Public Health Association, New York, 1964.
26. C. Cermelli, A. Moroni, P. Pietrosemoli, M. Pecorari and M. Portolani, Microbiologica, 15, 57 (1992).