Nonnucleoside human cytomegalovirus inhibitors: Synthesis and antiviral evaluation of (chlorophenylmethyl)benzothiadiazine dioxide derivatives

Journal of Medicinal Chemistry

Volumn 43, Issue 17, 2000, Pages 3267-3273

  Martinez, A ^a   Gil, C ^a   Perez, C ^a   Castro, A ^a   Prieto, C ^b   Otero, J ^b   Andrei, G ^c   Snoeck, R ^c   Balzarini, J ^c   De Clercq, E ^c  

^a INSTITUTO DE QUÍMICA MÉDICA   (Spain)

^b HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

(CHLORPHENYLMETHYL)BENZOTHIADIAZINE DIOXIDE DERIVATIVE; BENZOTHIADIAZINE DERIVATIVE; GANCICLOVIR; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ARTICLE; CELL GROWTH; CELL PROLIFERATION; CELL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOMEGALOVIRUS; CYTOTOXICITY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; IC 50; LUNG FIBROBLAST; LYMPHOCYTE; NONHUMAN; VIRUS INHIBITION; VIRUS REPLICATION; VIRUS STRAIN;

ANIMALS; ANTI-HIV AGENTS; ANTIVIRAL AGENTS; BENZOTHIADIAZINES; CERCOPITHECUS AETHIOPS; CYCLIC S-OXIDES; CYTOMEGALOVIRUS; HELA CELLS; HUMANS; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURE-ACTIVITY RELATIONSHIP; T-LYMPHOCYTES; VERO CELLS;

EID: 0034710709     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000118q     Document Type: Article

References (27)

1. Cytomegalovirus
2. Problems and progress in opportunistic infections
3. The outcome of congenital cytomegalovirus infection in relation to maternal antibody status
4. Ganciclovir. A review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy in cytomegalovirus infections
5. Foscarnet. A review of its antiviral activity, pharmacokinetic properties and therapeutic use in immunocompromised patients with cytomegalovirus retinitis
6. Therapeutic potential of HPMPC as an antiviral drug
7. Fomivirsen
8. Oral ganciclovir fails to prevent CMV in HIV trial
9. Detection of ganciclovir resistance mutations and quantitation of cytomegalovirus (CMV) DNA in leucocytes of patients with fatal disseminated CMV disease
10. Recent advances in antiviral research: Identification of inhibitors of the herpesvirus proteases
11. Gene therapy: Progress, new directions and issues
12. Novel agents for the treatment of human cytomegalovirus infection
13. New 1,2,6-thiadiazine dioxide acyclonucleosides: Synthesis and antiviral evaluation
14. Synthesis and antiviral activity of modified 1,2,6-thiadiazine dioxide acyclonucleosides
15. Benzothiadiazine dioxide acyclonucleosides as lead compounds for the development of new agents against human cytomegalovirus and Varicella-Zoster virus infections
16. Novel potential agents for human cytomegalovirus infection: Synthesis and antiviral activity evaluation of benzothiadiazine acyclonucleosides
17. Chlorophenyl-methyl benzothiadiazine dioxides derivatives: Potent human cytomegalovirus inhibitors
18. Sulfamoyl chloride, sulfamides and sulfimide
19. A general synthesis of N-glycosides
20. Synthesis and antiviral study of dihydrothieno and thianopyrimidine diones ayclic nucleosides as potential anti-HIV agents
21. Benzyl Derivatives of 2,1,3-benzo- and benzothieno[3,2-a]-thiadiazine 2,2-dioxides: First phosphodiesterase 7 inhibitors
22. On the tautomerism of 2,1,3-benzothiadiazinone S,S-dioxide and related compounds
23. Comparative activity of selected antiviral compounds against clinical isolates of varicalla-zoster virus
24. Antiviral activity of anticytomegalovirus agents (HPMPC, HP-MPA) assessed by a flow-cytometric method and DNA hybridization technique
25. In vitro and ex vivo test systems to rationalize drug design and delivery
26. Digital imaging as a detection for a fluorescent protease assay in 96-well and miniaturized assay plate formats