메뉴 건너뛰기




Volumn 280, Issue 1-2, 2009, Pages 71-78

Peoniflorin attentuates Aβ(1-42)-mediated neurotoxicity by regulating calcium homeostasis and ameliorating oxidative stress in hippocampus of rats

Author keywords

Alzheimer's disease; Beta amyloid; Calcium; Morris water maze test; Neuroprotective effect; Peoniflorin

Indexed keywords

AMYLOID BETA PROTEIN; CALCIUM; CARBONYL DERIVATIVE; GLUTATHIONE; MALONALDEHYDE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OLIGOMER; PAEONIFLORIN; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA-PROTEIN (1-42); BENZOIC ACID DERIVATIVE; BRIDGED COMPOUND; GLUCOSIDE; NEUROPROTECTIVE AGENT; PEPTIDE FRAGMENT;

EID: 63349109688     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jns.2009.01.027     Document Type: Article
Times cited : (114)

References (56)
  • 1
    • 0030902162 scopus 로고    scopus 로고
    • Dissociation of Alzheimer type pathology in a disconnected piece of cortex
    • Duyckaerts C., Uchihara T., Seilhean D., He Y., and Hauw J.J. Dissociation of Alzheimer type pathology in a disconnected piece of cortex. Acta Neuropathol 93 (1997) 501-507
    • (1997) Acta Neuropathol , vol.93 , pp. 501-507
    • Duyckaerts, C.1    Uchihara, T.2    Seilhean, D.3    He, Y.4    Hauw, J.J.5
  • 2
    • 0022639880 scopus 로고
    • Mechanisms of memory
    • Squire L.R. Mechanisms of memory. Science 232 (1986) 1612-1619
    • (1986) Science , vol.232 , pp. 1612-1619
    • Squire, L.R.1
  • 3
    • 0030808462 scopus 로고    scopus 로고
    • Aggregated amyloid-β protein induces cortical neuronal apoptosis and concomitant "apoptotic" pattern of gene induction
    • Estus S., Tucker H.M., Van Rooyen C., Wright S., Brigham E.F., Wogulis M., et al. Aggregated amyloid-β protein induces cortical neuronal apoptosis and concomitant "apoptotic" pattern of gene induction. J Neurosci 17 (1997) 7736-7745
    • (1997) J Neurosci , vol.17 , pp. 7736-7745
    • Estus, S.1    Tucker, H.M.2    Van Rooyen, C.3    Wright, S.4    Brigham, E.F.5    Wogulis, M.6
  • 4
    • 0032487648 scopus 로고    scopus 로고
    • Amyloid β-peptide induces apoptosis-related events in synapses and dendrites
    • Mattson M.P., Partin J., and Begley J.G. Amyloid β-peptide induces apoptosis-related events in synapses and dendrites. Hippocampus Res 807 (1998) 167-176
    • (1998) Hippocampus Res , vol.807 , pp. 167-176
    • Mattson, M.P.1    Partin, J.2    Begley, J.G.3
  • 5
    • 0344824654 scopus 로고    scopus 로고
    • Amyloid β-peptide (1-42)-associated free radical induced oxidative stress and neurodegeneration in Alzheimer's disease brain: mechanisms and consequences
    • Butterfield D.A. Amyloid β-peptide (1-42)-associated free radical induced oxidative stress and neurodegeneration in Alzheimer's disease brain: mechanisms and consequences. Curr Med Chem 10 (2003) 2651-2659
    • (2003) Curr Med Chem , vol.10 , pp. 2651-2659
    • Butterfield, D.A.1
  • 6
    • 0034681208 scopus 로고    scopus 로고
    • 2+ channel activity by β-amyloid-(1-40) in rat cortical synaptosomes and cultured cortical neurons. Modulation by the proinflammatory cytokine interleukin-1β
    • 2+ channel activity by β-amyloid-(1-40) in rat cortical synaptosomes and cultured cortical neurons. Modulation by the proinflammatory cytokine interleukin-1β. J Biol Chem 275 (2000) 4713-4718
    • (2000) J Biol Chem , vol.275 , pp. 4713-4718
    • MacManus, A.1    Ramsden, M.2    Murray, M.3    Henderson, Z.4    Pearson, H.A.5    Campbell, V.A.6
  • 7
    • 0037470822 scopus 로고    scopus 로고
    • Inhibition of L-type voltage dependent calcium channels causes impairment of long-term potentiation in the hippocampal CA1 region in vivo
    • Freir D.B., and Herron C.E. Inhibition of L-type voltage dependent calcium channels causes impairment of long-term potentiation in the hippocampal CA1 region in vivo. Brain Res 967 (2003) 27-36
    • (2003) Brain Res , vol.967 , pp. 27-36
    • Freir, D.B.1    Herron, C.E.2
  • 8
    • 0344936729 scopus 로고    scopus 로고
    • Possible causes of Alzheimer's disease: amyloid fragments, free radicals, and calcium homeostasis
    • Hölscher C. Possible causes of Alzheimer's disease: amyloid fragments, free radicals, and calcium homeostasis. Neurobiol Dis 5 (1998) 129-141
    • (1998) Neurobiol Dis , vol.5 , pp. 129-141
    • Hölscher, C.1
  • 9
    • 27844498075 scopus 로고    scopus 로고
    • Development of beta-amyloid-induced neurodegeneration in Alzheimer's disease and novel neuroprotective strategies
    • Hölscher C. Development of beta-amyloid-induced neurodegeneration in Alzheimer's disease and novel neuroprotective strategies. Rev Neurosci 16 (2005) 181-212
    • (2005) Rev Neurosci , vol.16 , pp. 181-212
    • Hölscher, C.1
  • 10
    • 3442886811 scopus 로고    scopus 로고
    • The pathophysiology of mitochondrial cell death
    • Green D.R., and Kroemer G. The pathophysiology of mitochondrial cell death. Science 305 (2004) 626-629
    • (2004) Science , vol.305 , pp. 626-629
    • Green, D.R.1    Kroemer, G.2
  • 11
    • 0030745646 scopus 로고    scopus 로고
    • Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
    • Zou H., Henzel W.J., Liu X., Lutschg A., and Wang X. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell 90 (1997) 405-413
    • (1997) Cell , vol.90 , pp. 405-413
    • Zou, H.1    Henzel, W.J.2    Liu, X.3    Lutschg, A.4    Wang, X.5
  • 12
    • 0036591849 scopus 로고    scopus 로고
    • Lipid peroxidation and protein oxidation in Alzheimer's disease brain: potential causes and consequences involving amyloid β-peptide associated free radical oxidative stress
    • Butterfield D.A., and Lauderback C.M. Lipid peroxidation and protein oxidation in Alzheimer's disease brain: potential causes and consequences involving amyloid β-peptide associated free radical oxidative stress. Free Radic Biol Med 32 (2002) 1050-1060
    • (2002) Free Radic Biol Med , vol.32 , pp. 1050-1060
    • Butterfield, D.A.1    Lauderback, C.M.2
  • 13
    • 8744276616 scopus 로고    scopus 로고
    • Amyloid β-peptide(1-42) contributes to the oxidative stress and neurodegeneration found in Alzheimer disease brain
    • Butterfield D.A., and Boyd-Kimball D. Amyloid β-peptide(1-42) contributes to the oxidative stress and neurodegeneration found in Alzheimer disease brain. Brain Pathol 14 (2004) 426-432
    • (2004) Brain Pathol , vol.14 , pp. 426-432
    • Butterfield, D.A.1    Boyd-Kimball, D.2
  • 14
    • 0028233494 scopus 로고
    • Hydrogen peroxide mediates amyloid beta protein toxicity
    • Behl C., Davis J.B., Lesley R., and Schubert D. Hydrogen peroxide mediates amyloid beta protein toxicity. Cell 77 (1994) 817-827
    • (1994) Cell , vol.77 , pp. 817-827
    • Behl, C.1    Davis, J.B.2    Lesley, R.3    Schubert, D.4
  • 15
    • 84855719563 scopus 로고    scopus 로고
    • Amyloid β peptide impairs glucose transport in hippocampal and cortical neurons: involvement of membrane lipid peroxidation
    • Mark R.J., Geddes J.W., Uchida K., and Mattson M.P. Amyloid β peptide impairs glucose transport in hippocampal and cortical neurons: involvement of membrane lipid peroxidation. J Neurosci 17 (1997) 1646-1654
    • (1997) J Neurosci , vol.17 , pp. 1646-1654
    • Mark, R.J.1    Geddes, J.W.2    Uchida, K.3    Mattson, M.P.4
  • 16
    • 0033133579 scopus 로고    scopus 로고
    • In vitro and in vivo oxidative stress associated with Alzheimer's amyloid β peptide (1-42)
    • Yatin S.M., Varadarajan S., Link C.D., and Butterfield D.A. In vitro and in vivo oxidative stress associated with Alzheimer's amyloid β peptide (1-42). Neurobiol Aging 20 (1999) 325-330
    • (1999) Neurobiol Aging , vol.20 , pp. 325-330
    • Yatin, S.M.1    Varadarajan, S.2    Link, C.D.3    Butterfield, D.A.4
  • 17
    • 3042559829 scopus 로고    scopus 로고
    • Potent inhibitory effect of flavonoids in Scutellaria baicalensis on amyloid β protein-induced neurotoxicity
    • Heo H.J., Kim D.O., Choi S.J., Shin D.H., and Lee C.Y. Potent inhibitory effect of flavonoids in Scutellaria baicalensis on amyloid β protein-induced neurotoxicity. J Agric Food Chem 52 (2004) 4128-4132
    • (2004) J Agric Food Chem , vol.52 , pp. 4128-4132
    • Heo, H.J.1    Kim, D.O.2    Choi, S.J.3    Shin, D.H.4    Lee, C.Y.5
  • 18
    • 0035895957 scopus 로고    scopus 로고
    • The neuroprotective effects of phytoestrogens on amyloid β protein-induced toxicity are mediated by abrogating the activation of caspase cascade in rat cortical neurons
    • Wang C.N., Chi C.W., Lin Y.L., Chen C.F., and Shao Y.J. The neuroprotective effects of phytoestrogens on amyloid β protein-induced toxicity are mediated by abrogating the activation of caspase cascade in rat cortical neurons. J Biol Chem 276 (2001) 5287-5295
    • (2001) J Biol Chem , vol.276 , pp. 5287-5295
    • Wang, C.N.1    Chi, C.W.2    Lin, Y.L.3    Chen, C.F.4    Shao, Y.J.5
  • 19
    • 0034304391 scopus 로고    scopus 로고
    • NO synthase and NO-dependent signal pathways in brain aging and neurodegenerative disorders: the role of oxidant/antioxidant balance
    • Calabrese V., Bates T.E., and Stella A.M. NO synthase and NO-dependent signal pathways in brain aging and neurodegenerative disorders: the role of oxidant/antioxidant balance. Neurochem Res 25 (2000) 1315-1341
    • (2000) Neurochem Res , vol.25 , pp. 1315-1341
    • Calabrese, V.1    Bates, T.E.2    Stella, A.M.3
  • 20
    • 33846863589 scopus 로고    scopus 로고
    • Nitric oxide and peroxynitrite in health and disease
    • Pacher P., Beckman J.S., and Liaudet L. Nitric oxide and peroxynitrite in health and disease. Physiol Rev 87 (2007) 315-424
    • (2007) Physiol Rev , vol.87 , pp. 315-424
    • Pacher, P.1    Beckman, J.S.2    Liaudet, L.3
  • 21
    • 0344196903 scopus 로고    scopus 로고
    • NO-dependent protein nitration: a cell signaling event or an oxidative inflammatory response?
    • Schopfer F.J., Baker P.R., and Freeman B.A. NO-dependent protein nitration: a cell signaling event or an oxidative inflammatory response?. Trends Biochem Sci 28 (2003) 646-654
    • (2003) Trends Biochem Sci , vol.28 , pp. 646-654
    • Schopfer, F.J.1    Baker, P.R.2    Freeman, B.A.3
  • 22
    • 0027236319 scopus 로고
    • Involvement of β-adrenergic systems in the antagonizing effect of paeoniflorin on the scopolamine-induced deficit in radical maze performance in rats
    • Ohta H., Matsumoto K., and Watanabe H. Involvement of β-adrenergic systems in the antagonizing effect of paeoniflorin on the scopolamine-induced deficit in radical maze performance in rats. J Pharmaco1 62 3 (1993) 45
    • (1993) J Pharmaco1 , vol.62 , Issue.3 , pp. 45
    • Ohta, H.1    Matsumoto, K.2    Watanabe, H.3
  • 23
    • 63349110905 scopus 로고    scopus 로고
    • Studying the improving effect of peoniflorin on cerebral anoxia and ischemia reperfusion injury
    • Mo L.L., Hu X.G., and Xiang X. Studying the improving effect of peoniflorin on cerebral anoxia and ischemia reperfusion injury. Chin Mag Clin Med Prof Res 14 (2008) 297-298
    • (2008) Chin Mag Clin Med Prof Res , vol.14 , pp. 297-298
    • Mo, L.L.1    Hu, X.G.2    Xiang, X.3
  • 24
    • 33646825598 scopus 로고    scopus 로고
    • Influence of different processing technique on the contents and analgesic effect in radix Paeoniae Alba
    • Liu B.Y., Yan X.X., Li W., and Liu P. Influence of different processing technique on the contents and analgesic effect in radix Paeoniae Alba. Pharm J Chin People's Liberation Army 21 (2005) 167-169
    • (2005) Pharm J Chin People's Liberation Army , vol.21 , pp. 167-169
    • Liu, B.Y.1    Yan, X.X.2    Li, W.3    Liu, P.4
  • 25
    • 33846283845 scopus 로고    scopus 로고
    • Effects of paeoniflorin on cerebral energy metabolism, nitric oxide and nitric oxide synthase after cerebral ischemia in mongoliagerbils
    • Sun R., Lv L.L., and Liu G.Q. Effects of paeoniflorin on cerebral energy metabolism, nitric oxide and nitric oxide synthase after cerebral ischemia in mongoliagerbils. Chin J Chin Mater Med 31 10 (2006) 832-835
    • (2006) Chin J Chin Mater Med , vol.31 , Issue.10 , pp. 832-835
    • Sun, R.1    Lv, L.L.2    Liu, G.Q.3
  • 26
    • 0033514079 scopus 로고    scopus 로고
    • Delayed behavioral effects following intrahippocampal injection of aggregated Aβ
    • O'Hare E., Weldon D.T., Mantyh P.W., Ghilardi J.R., Finke M.P., Kuskowski M.A., et al. Delayed behavioral effects following intrahippocampal injection of aggregated Aβ. Brain Res 815 1 (1999) 1-10
    • (1999) Brain Res , vol.815 , Issue.1 , pp. 1-10
    • O'Hare, E.1    Weldon, D.T.2    Mantyh, P.W.3    Ghilardi, J.R.4    Finke, M.P.5    Kuskowski, M.A.6
  • 28
    • 0034708402 scopus 로고    scopus 로고
    • Bis(7)-tacrine, a novel acetylcholinesterase inhibitor, reverses AF64A-induced deficits in navigational memory in rats
    • Liu J., Ho W., Lee N.T., Carlier P.R., Pang Y., and Han Y. Bis(7)-tacrine, a novel acetylcholinesterase inhibitor, reverses AF64A-induced deficits in navigational memory in rats. Neurosci Lett 282 (2000) 165-168
    • (2000) Neurosci Lett , vol.282 , pp. 165-168
    • Liu, J.1    Ho, W.2    Lee, N.T.3    Carlier, P.R.4    Pang, Y.5    Han, Y.6
  • 29
    • 0019167355 scopus 로고
    • Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine
    • Griffith O.W. Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal Biochem 106 (1980) 207-212
    • (1980) Anal Biochem , vol.106 , pp. 207-212
    • Griffith, O.W.1
  • 30
    • 63349090603 scopus 로고    scopus 로고
    • DNPH-chromatometry: a simple assay for determination of carbonyl protein level
    • Duan L.J., Liu Y.S., Zhu Y., and Yang Y. DNPH-chromatometry: a simple assay for determination of carbonyl protein level. J Toxicol 19 4 (2005) 320-322
    • (2005) J Toxicol , vol.19 , Issue.4 , pp. 320-322
    • Duan, L.J.1    Liu, Y.S.2    Zhu, Y.3    Yang, Y.4
  • 31
    • 0018069570 scopus 로고
    • Determination of malondialdehyde precursor in tissues by thiobarbituric acid test
    • Uchiyama M., and Mihara M. Determination of malondialdehyde precursor in tissues by thiobarbituric acid test. Anal Biochem 86 (1978) 271-278
    • (1978) Anal Biochem , vol.86 , pp. 271-278
    • Uchiyama, M.1    Mihara, M.2
  • 32
    • 34548415097 scopus 로고    scopus 로고
    • Modulation of stress-induced neurobehavioral changes and hippocampus oxidative injury by nitric oxide (NO) mimetics in rats
    • Gulati K., Chakraborti A., and Ray A. Modulation of stress-induced neurobehavioral changes and hippocampus oxidative injury by nitric oxide (NO) mimetics in rats. Behav Hippocampus Res 183 (2007) 226-230
    • (2007) Behav Hippocampus Res , vol.183 , pp. 226-230
    • Gulati, K.1    Chakraborti, A.2    Ray, A.3
  • 33
    • 0032777013 scopus 로고    scopus 로고
    • Nitric oxide, superoxide and hydrogen peroxide production in hippocampus mitochondria after haloperidol treatment
    • Lores Arnaiz S., Coronel M.F., and Boveris A. Nitric oxide, superoxide and hydrogen peroxide production in hippocampus mitochondria after haloperidol treatment. Nitric Oxide Biol Chem 3 (1999) 235-243
    • (1999) Nitric Oxide Biol Chem , vol.3 , pp. 235-243
    • Lores Arnaiz, S.1    Coronel, M.F.2    Boveris, A.3
  • 34
    • 1342306816 scopus 로고    scopus 로고
    • Determination of paeoniflorin in rat hippocampus by high-performance liquid chromatography after intravenous administration of Paeoniae radix extract
    • He X., Xing D., Ding Y., Li Y., Xiang L., Wang W., et al. Determination of paeoniflorin in rat hippocampus by high-performance liquid chromatography after intravenous administration of Paeoniae radix extract. J Chromatogr B 802 (2004) 277-281
    • (2004) J Chromatogr B , vol.802 , pp. 277-281
    • He, X.1    Xing, D.2    Ding, Y.3    Li, Y.4    Xiang, L.5    Wang, W.6
  • 36
    • 34547977655 scopus 로고    scopus 로고
    • The effects of chronic estradiol treatment on working memory deficits induced by combined infusion of β-amyloid (1-42) and ibotenic acid
    • Hruska Z., and Dohanich G.P. The effects of chronic estradiol treatment on working memory deficits induced by combined infusion of β-amyloid (1-42) and ibotenic acid. Horm Behav 52 3 (2007) 297-306
    • (2007) Horm Behav , vol.52 , Issue.3 , pp. 297-306
    • Hruska, Z.1    Dohanich, G.P.2
  • 37
    • 0024324666 scopus 로고
    • Glutathione is present in high concentrations in cultured astrocytes but not in cultured neurons
    • Raps S.P., Lai J.C., Hertz L., and Cooper A.J. Glutathione is present in high concentrations in cultured astrocytes but not in cultured neurons. Brain Res 493 (1989) 398-401
    • (1989) Brain Res , vol.493 , pp. 398-401
    • Raps, S.P.1    Lai, J.C.2    Hertz, L.3    Cooper, A.J.4
  • 38
    • 0036203408 scopus 로고    scopus 로고
    • Oxidative stress in rat cortical neurons and astrocytes induced by paraquat in vitro
    • Schmuck G., Rohrdanz E., Tran-Thi Q.H., Kahl R., and Schluter G. Oxidative stress in rat cortical neurons and astrocytes induced by paraquat in vitro. Neurotox Res 4 (2002) 1-13
    • (2002) Neurotox Res , vol.4 , pp. 1-13
    • Schmuck, G.1    Rohrdanz, E.2    Tran-Thi, Q.H.3    Kahl, R.4    Schluter, G.5
  • 39
    • 18244391440 scopus 로고    scopus 로고
    • Calcineurin triggers reactive/inflammatory processes in astrocytes and is upregulated in aging and Alzheimer's models
    • Norris C.M., Kadish I., Blalock E.M., Chen K.C., Thibault V., Porter N.M., et al. Calcineurin triggers reactive/inflammatory processes in astrocytes and is upregulated in aging and Alzheimer's models. J Neurosci 25 (2005) 4649-4658
    • (2005) J Neurosci , vol.25 , pp. 4649-4658
    • Norris, C.M.1    Kadish, I.2    Blalock, E.M.3    Chen, K.C.4    Thibault, V.5    Porter, N.M.6
  • 40
    • 0027730919 scopus 로고
    • Calcium buffering properties of calbindin D28k and parvalbumin in rat sensory neurones
    • Chard P.S., Bleakman D., Christakos S., Fullmer C.S., and Miller R.J. Calcium buffering properties of calbindin D28k and parvalbumin in rat sensory neurones. J Physiol Lond 472 (1993) 341-357
    • (1993) J Physiol Lond , vol.472 , pp. 341-357
    • Chard, P.S.1    Bleakman, D.2    Christakos, S.3    Fullmer, C.S.4    Miller, R.J.5
  • 42
    • 0025923797 scopus 로고
    • Calbindin-D28K (CaBP) levels and calcium currents in acutely dissociated epileptic neurons
    • Kohr G., Lambert C.E., and Mody I. Calbindin-D28K (CaBP) levels and calcium currents in acutely dissociated epileptic neurons. Exp Brain Res 85 (1991) 543-551
    • (1991) Exp Brain Res , vol.85 , pp. 543-551
    • Kohr, G.1    Lambert, C.E.2    Mody, I.3
  • 43
    • 0023231576 scopus 로고
    • GABAergic neurons containing the Ca21-binding protein parvalbumin in the rat hippocampus and dentate gyrus
    • Kosaka T., Katsumaru H., Hama K., Wu J.Y., and Heizmann C.W. GABAergic neurons containing the Ca21-binding protein parvalbumin in the rat hippocampus and dentate gyrus. Brain Res 419 (1987) 119-130
    • (1987) Brain Res , vol.419 , pp. 119-130
    • Kosaka, T.1    Katsumaru, H.2    Hama, K.3    Wu, J.Y.4    Heizmann, C.W.5
  • 44
    • 0024545587 scopus 로고
    • Calcium-binding protein (calbindin-D28k) and parvalbumin immunohistochemistry: localization in the rat hippocampus with specific reference to the selective vulnerability of hippocampal neurons to seizure activity
    • Sloviter R.S. Calcium-binding protein (calbindin-D28k) and parvalbumin immunohistochemistry: localization in the rat hippocampus with specific reference to the selective vulnerability of hippocampal neurons to seizure activity. J Comp Neurol 280 (1989) 183-196
    • (1989) J Comp Neurol , vol.280 , pp. 183-196
    • Sloviter, R.S.1
  • 45
    • 3042595335 scopus 로고    scopus 로고
    • Excitotoxic calcium overload in a subpopulation of mitochondria triggers delayed death in hippocampal neurons
    • Pivovarova N.B., Nguyen H.V., Winters C.A., Brantner C.A., Smith C.L., and Andrews S.B. Excitotoxic calcium overload in a subpopulation of mitochondria triggers delayed death in hippocampal neurons. J Neurosci 24 (2004) 5611-5622
    • (2004) J Neurosci , vol.24 , pp. 5611-5622
    • Pivovarova, N.B.1    Nguyen, H.V.2    Winters, C.A.3    Brantner, C.A.4    Smith, C.L.5    Andrews, S.B.6
  • 46
    • 16244405250 scopus 로고    scopus 로고
    • Hepatitis C virus, ER stress, and oxidative stress
    • Tardif K.D., Waris G., and Siddiqui A. Hepatitis C virus, ER stress, and oxidative stress. Trends Microbiol 13 (2005) 159-163
    • (2005) Trends Microbiol , vol.13 , pp. 159-163
    • Tardif, K.D.1    Waris, G.2    Siddiqui, A.3
  • 47
    • 0030768085 scopus 로고    scopus 로고
    • Stimulus intensity, cell excitation and the N-methyl-d-aspartate receptor component of sensory responses in the rat spinal cord in vivo
    • Chizh B.A., Cumberbatch M.J., Herrero J.F., Stirk G.C., and Headley P.M. Stimulus intensity, cell excitation and the N-methyl-d-aspartate receptor component of sensory responses in the rat spinal cord in vivo. Neuroscience 80 (1997) 251-265
    • (1997) Neuroscience , vol.80 , pp. 251-265
    • Chizh, B.A.1    Cumberbatch, M.J.2    Herrero, J.F.3    Stirk, G.C.4    Headley, P.M.5
  • 48
    • 0035875690 scopus 로고    scopus 로고
    • Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis
    • Pratico D., Uryu K., Leight S., Trojanowski J.Q., and Lee V.M. Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis. J Neurosci 21 (2001) 4183-4187
    • (2001) J Neurosci , vol.21 , pp. 4183-4187
    • Pratico, D.1    Uryu, K.2    Leight, S.3    Trojanowski, J.Q.4    Lee, V.M.5
  • 49
    • 18844444191 scopus 로고    scopus 로고
    • Role of glutathione in intracellular amyloid-a precursor protein/carboxy-terminal fragment aggregation and associated cytotoxicity
    • Woltjer R.L., Nghiem W., Maezawa I., Milatovic D., Vaisar T., Montine K.S., et al. Role of glutathione in intracellular amyloid-a precursor protein/carboxy-terminal fragment aggregation and associated cytotoxicity. J Neurochem 93 (2005) 1047-1056
    • (2005) J Neurochem , vol.93 , pp. 1047-1056
    • Woltjer, R.L.1    Nghiem, W.2    Maezawa, I.3    Milatovic, D.4    Vaisar, T.5    Montine, K.S.6
  • 50
    • 0038452658 scopus 로고    scopus 로고
    • Changes in intracellular calcium and glutathione in astrocytes as the primary mechanisms of amyloid neurotoxicity
    • Abramov A.Y., Canevari L., and Duchen M.R. Changes in intracellular calcium and glutathione in astrocytes as the primary mechanisms of amyloid neurotoxicity. J Neurosci 23 (2003) 5088-5095
    • (2003) J Neurosci , vol.23 , pp. 5088-5095
    • Abramov, A.Y.1    Canevari, L.2    Duchen, M.R.3
  • 51
    • 0036628724 scopus 로고    scopus 로고
    • Role of oxidative stress and protein oxidation in the aging process
    • Sohal R.S. Role of oxidative stress and protein oxidation in the aging process. Free Radic Biol Med 33 (2002) 37-44
    • (2002) Free Radic Biol Med , vol.33 , pp. 37-44
    • Sohal, R.S.1
  • 52
    • 0032031810 scopus 로고    scopus 로고
    • Beta-amyloid-induced cholinergic denervation correlates with enhanced nitric oxide synthase activity in rat cerebral cortex: reversal by NMDA receptor blockade
    • O'Mahony S.O., Harkany T., Rensink A.A., Abraham I., De Jong G.I., Varga J.L., et al. Beta-amyloid-induced cholinergic denervation correlates with enhanced nitric oxide synthase activity in rat cerebral cortex: reversal by NMDA receptor blockade. Hippocampus Res Bull 45 (1998) 405-411
    • (1998) Hippocampus Res Bull , vol.45 , pp. 405-411
    • O'Mahony, S.O.1    Harkany, T.2    Rensink, A.A.3    Abraham, I.4    De Jong, G.I.5    Varga, J.L.6
  • 53
    • 1842738222 scopus 로고    scopus 로고
    • Kinetics of the neuroinflammation-oxidative stress correlation in rat brain following the injection of fibrillar amyloid-b onto the hippocampus in vivo
    • Rosales-Corral S., Tan D.X., Reiter R.J., Valdivia-Velazquez M., Acosta-Martinez J.P., and Ortiz G.G. Kinetics of the neuroinflammation-oxidative stress correlation in rat brain following the injection of fibrillar amyloid-b onto the hippocampus in vivo. J Neuroimmunol 150 (2004) 20-28
    • (2004) J Neuroimmunol , vol.150 , pp. 20-28
    • Rosales-Corral, S.1    Tan, D.X.2    Reiter, R.J.3    Valdivia-Velazquez, M.4    Acosta-Martinez, J.P.5    Ortiz, G.G.6
  • 54
    • 27744461126 scopus 로고    scopus 로고
    • Nitric oxide modulates calcium entry through P/Q-type calcium channels and N-methyl-d-aspartate receptors in rat cortical neurons
    • Petzold G.C., Scheibe F., Braun J.S., Freyer D., Priller J., Dirnagl U., et al. Nitric oxide modulates calcium entry through P/Q-type calcium channels and N-methyl-d-aspartate receptors in rat cortical neurons. Hippocampus Res 1063 (2005) 9-14
    • (2005) Hippocampus Res , vol.1063 , pp. 9-14
    • Petzold, G.C.1    Scheibe, F.2    Braun, J.S.3    Freyer, D.4    Priller, J.5    Dirnagl, U.6
  • 55
    • 0032876784 scopus 로고    scopus 로고
    • Activation of caspase-3 in beta-amyloid-induced apoptosis of cultured rat cortical neurons
    • Harada J., and Sugimoto M. Activation of caspase-3 in beta-amyloid-induced apoptosis of cultured rat cortical neurons. Brain Res 842 (1999) 311-323
    • (1999) Brain Res , vol.842 , pp. 311-323
    • Harada, J.1    Sugimoto, M.2
  • 56
    • 0036892618 scopus 로고    scopus 로고
    • Involvement of double-stranded RNA-dependent protein kinase and phosphorylation of eukaryotic initiation factor-2 alpha in neuronal degeneration
    • Chang R.C.C., Suen K.C., Ma C.H., Elyaman W., Ng H.K., and Hugon J. Involvement of double-stranded RNA-dependent protein kinase and phosphorylation of eukaryotic initiation factor-2 alpha in neuronal degeneration. J Neurochem 83 (2002) 1215-1225
    • (2002) J Neurochem , vol.83 , pp. 1215-1225
    • Chang, R.C.C.1    Suen, K.C.2    Ma, C.H.3    Elyaman, W.4    Ng, H.K.5    Hugon, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.